Basic Research > Cancer Initiation and Progression > Dr Lugang Yu

	Research is focused on functional significance of cellular glycosylation and carbohydrate-binding protein (lectins, e.g. the galactoside-binding galectins) in colorectal cancer progression and metastasis. Current research is support by: Cancer Research UK, Medical Research Council, American Institute for Cancer Research, British Council, North West Cancer Research Fund

Education and qualifications

BSc (1982) and MSc (1986) from Shandong University, China. Previously worked in Beijing Institute of Pharmacology and Toxicology before moved to the University of Liverpool as a European Commission Research Fellow in 1991; obtained PhD from the University of Liverpool in 1996, appointed as Lecturer in Medicine in 2000, Senior Lecturer in 2006 and Reader in 2011.

Administrative role: Deputy Director, Liverpool Centre for Glycobiology

Memberships of professional bodies
UK Glycoscience Forum
International Consortium for Functional Glycomics
UK Medical Research Society
UK Biochemical Society
American Glycobiology Society

Editorial board members:
Chromatography
World Journal of Gastrointestinal Oncology
Oncology Letters
Glycobiology Insights
World Journal of Biological Chemistry

Rhodes JM, Campbell BJ, Yu LG. (2010) Glycosylation and Disease . In: Macmillan Reference Ltd., London ed(s). Encyclopaedia of Life Sciences. . London, Macmillan Reference Ltd., .

Campbell BJ, Yu LG and Rhodes JM. (2007) Mucosal glycocojugates in inflammatory bowel disease and colon cancer. In: Claire Sansom and Ofer Markman ed(s). Glycobiology. London, Scion Publishing Ltd .

Rhodes JM and Yu LG. (2000) Glycosylation and Disease. In: Macmillan Re ed(s). Encyclopedia of Life Sciences. London, Macmillan Reference Ltd.

Yu LG and Rhodes JM. (1999) Mitogenic effect of lectins on epithelial cells. In: Rhodes JM and Milton JD ed(s). Methods in Molecular Medicine -- Lectin Methods and Protocols. Totowa, Humana Press

Barrow H, Guo X, Wandall HH, Pedersen JW, Fu B, Zhao Q, Chen C, Rhodes JM, Yu LG. (2011). Serum galectin-2, -3, -4 and -8 are highly increased in colon and breast cancer patients and promote cancer cell adhesion to blood vascular endothelium. Clin Cancer Res

Newlaczyl AU and Yu LG.  (2011). Galectin-3 – a jack-of-all-trades in cancer. Cancer Lett (In press).

Barrow H, Rhodes JM and Yu LG. (2011). The role of galectins in colorectal cancer progression. Int J Cancer. 129:1-8.

Chachadi VB, Inamdar SR, Yu LG, Rhodes JM, Swamy BM. (2011). Exquisite binding specificity of Sclerotium rolfsii lectin toward TF-related O-linked mucin-type glycans. Glycoconj J 28:49-56.

Yu LG. (2010). Circulating galectin-3 in the bloodstream: an emerging promoter of cancer metastasis. World J Gastrointest Oncol 2:177-80.

Zhao Q, Barclay M, Hilkens J, Guo X, Barrow H, Rhodes JM, Yu LG. (2010). Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis. Mol Cancer 9:154.

Tam B, Rhodes JM, Yu LG (2010). Lack of effect of O-glycosylation and sialylation inhibitors on classical NLS-dependent nuclear protein import. Glycobiology Insights 2:75-82.

Zhang H, Song YN, Liu WG, Guo XL, Yu LG. (2010). Regulation and role of organic anion-transporting polypeptides (OATPs) in drug delivery at the choroid plexus. J Clin Neurosci 17:679-84.

Zhao Q, Guo X, Stone P, Nash G, Hilkens J, Rhodes JM, Yu LG. (2009). Circulating galectin-3 promotes metastasis by modifying MUC1 localization on cancer cell surface. Cancer Res 69:6799-806.

Gou XL, Leng P, Yang Y, Yu LG and Lou HX. (2008). Plagiochin E, a botanic-derived phenolic compound, reverses fungal resistance to fluconazole relating to the efflux pump. J Appl Microbiol 104:831-38.

Rhodes JM, Campbell BJ and Yu LG. (2008). Lectin-epithelial interactions in the human colon. Biochem Soc Tran. 36:1482-1486.

Yu LG. (2007). The Thomsen-Friedenreich carbohydrate antigen in cancer progression. Glycoconj J 24:411-20.

Yu LG, Andrews N, Zhao Q, Williams JF, Connor LJ, Gerosimenko OV, Hilkens J, Hirabayashi J, Kasai K and Rhodes JM. (2007). Galectin-3 interaction with Thomsen-Friedenreich oligosaccharide on cancer-associated MUC1 causes increased cancer cell-endothelial adhesion. J Biol Chem 282: 773-781.