Translational Research > Applied Cancer Biology > Professor Ross Sibson
- Introduction
- Biography
- Key Publications
- Recent Publications
- Group Members
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The core objective of the group is to accuratley classify and stratify the biological genotypes and phenotypes of individual cancers so that this new information becomes translated into clinical applications through the development of biomarkers for early detection and prognosis, as well as the identification of new therapeutic targets. The research themes include the identification of genes and genetic mechanisms that affect cancer cell proliferation, angiogenesis, invasion and metastasis, utilising techniques such as next generation sequencing and mass spectrometry, which will extend the investigations with DNA and protein markers. |
Education and qualifications
1983: PhD Biochemistry, Victoria University of Manchester.
1979: BSc (Hons), Biology, University of York.
Appointments
2007 to present: Professor, Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool & Director of Research, Applied Cancer Biology Research Group.
1994-2009: Director of Research, Clatterbridge Cancer Research Trust.
2005-2008: Director of Research, InteraSeq Genetics.
1994: Principal Research Biologist, Glaxo Research and Development Limited.
1990-1994: Biological Manager, Medical Research Council (MRC), U.K.
1985-1990: Senior Development Scientist, Amersham Int. plc., Division of Molecular Biology.
Dunn J, Baborie A, Alam F, Joyce K, Moxham M, Sibson R, Crooks D, Husband D, Shenoy A, Brodbelt A, Wong H, Liloglou T, Haylock B, Walker C. Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy. Br J Cancer. 2009 Jul 7;101(1):124-31. Epub 2009 Jun 16.
Davies MP, Barraclough DL, Stewart C, Joyce KA, Eccles RM, Barraclough R, Rudland PS, Sibson DR. Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer. Int J Cancer. 2008; 123:85-8
Innes HE, Liu D, Barraclough R, Davies MP, O'Neill PA, Platt-Higgins A, de Silva Rudland S, Sibson DR, Rudland PS. Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients. Br J Cancer. 2006; 94:1057-65
Dong Liu, Philip S. Rudland, D. Ross Sibson, Angela Platt-Higgins and Roger Barraclough. Human Homologue of Cement Gland Protein, a Novel Metastasis-inducer Associated with Breast Carcinomas. Cancer Research (2005) 65:3796-805
D.R. Sibson, F.E.M. Gibbs. Molecular indexing of human genomic DNA. Nucleic Acids Research (2001) 29:E95.
B.H. Lloyd, R.V. Giles, D.G. Spiller, J. Grybowske, D.M. Tidd, D.R. Sibson. Determination of optimal sites of antisense oligonucleotide cleavage within TNFa mRNA. Nucleic Acids Research (2001) 29: 3664-3673
Arvind K Arya, Ashraf El-Fert, Timothy Devling, Richard M Eccles, Mohammed Afeef Aslam, Carlos P. Rubbi, Nikolina Vlatkovi?, John Fenwick, Bryony H Lloyd, David R Sibson, Terence M Jones and Mark T. Boyd. Nutlin-3, the small molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53. Br J Cancer. In Press
Dunn J, Baborie A, Alam F, Joyce K, Moxham M, Sibson R, Crooks D, Husband D, Shenoy A, Brodbelt A, Wong H, Liloglou T, Haylock B, Walker C. Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy. Br J Cancer. 2009 Jul 7;101(1):124-31. Epub 2009 Jun 16.
Dong Liu Barraclough, Susan Sewart, Philip S. Rudland, Balvinder S. Shoker, Ross D. Sibson, Roger Barraclough and Michael P. A. Davies. Microarray analysis of suppression subtracted hybridisation libraries identifies genes associated with breast cancer progression. Cellular Oncology 2010;32(1-2):87-99.
Davies MP, Barraclough DL, Stewart C, Joyce KA, Eccles RM, Barraclough R, Rudland PS, Sibson DR. Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer. Int J Cancer. 2008; 123:85-8
| Biography | Role | Telephone | Location | ||
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Professor Ross Sibson | Professor of Applied Cancer Biology |  |
+44(0)151 794 8822 | Room G14 - Centre |
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Dr Stephen Bennett | Research Associate | |
+44(0)151 794 8872 | Room G14 - Centre |
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Mrs Priyanka Bhattacharya | Research Assistant | |
+44(0)151 794 8872 | Room G14 - Centre |
| Dr Julie Dunn | Research Associate | |
+44(0)151 794 8872 | Room G14 - Centre | |
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Mr Richard Eccles | Research Assistant | |
+44(0)151 794 8872 | Room G14 - Centre |
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Dr Fiona Gibbs | Research Associate | |
+44(0)151 794 8872 | Room G14 - Centre |
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Dr Nigel Halliwell | Research Associate | |
+44(0)151 794 8872 | Room G14 - Centre |
| Mrs Kathryn Joyce | Research Assistant | |
+44(0)151 794 8872 | Room G14 - Centre | |
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Dr Bryony Lloyd | Research Associate | |
+44(0)151 794 8872 | Room G14 - Centre |
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Dr Elisabeth Shaw | Research Associate | |
+44(0)151 794 8872 | Room G14 - Centre |
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Dr Shirley Smith | Research Associate | |
+44(0)151 794 8872 | Room G14 - Centre |
| Administrative and Technical Staff | |||||
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Mrs Lynne Fordham | Laboratory Technician | |
+44(0)151 794 8872 | Room G14 - Centre |
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