Clinical & Translational Research > Head and Neck Cancer > Mr Richard Shaw

Richard trained first in dentistry at Bristol then in medicine & continued surgical training in Glasgow. After higher training in oral and maxillofacial surgery in Liverpool he subsequently completed an interface fellowship in head and neck surgery. He was one of the first OMFS surgeons awarded a Royal College of Surgeons of England Research Fellowship enabling him to undertake his thesis entitled “Epigenetic biomarkers in head and neck cancer” which was presented as an invited keynote lecture at the AHNS Quadrennial International Head & Neck Meeting in 2008. Travelling fellowships were completed in the H&N departments at MSKCC New York in 2003 and the MD Anderson in 2005. Richard has enthusiasm for many areas of head and neck oncology including premalignant lesions, prognostic factors, microvascular reconstruction (particularly in perforator flaps) and mandible/midface reconstruction. His translational interest is in molecular biomarkers, in particular epigenetic silencing of tumour suppressor genes, HPV related HNSCC and the molecular determinants of metastasis.

He is also an active contributor to and on the management board of Liverpool Cancer Trials Unit, LECMC, University Hospital Aintree R&D Board, the NCRI Clinical Studies Groups in Head and Neck Oncology and Biomarkers & Imaging , Royal College of Surgeons of England Academic and Research Board, Council of the International Academy of Oral Oncology, DoH National Working Party for Improving Recruitment in Interventional Trials, British Association of Oral & Maxillofacial Surgeons Research Sub-group. With clinical and basic science colleagues, Richard co-founded the new Merseyside H&N Oncology Research group (MHNORG) within the CRUK Cancer Centre in Liverpool.  He is Chief investigator for three CR-UK clinical trials: HOPON, TITAN and DAHANCA-21. Richard also has an interest in training and education and is a regular faculty member on RCSEng CCrISP, Liverpool Practical Microvascular courses as well as undergraduate MBChB and BDS lecturing.  Contact Details Tel: 0151 706 4845 Email: Richard.Shaw@liverpool.ac.uk

Education and qualifications

2010: PGCert (distinction), University of Liverpool.

2006: MD, University of Liverpool.

1998: MBChB (Hons), University of Glasgow.

1990: BDS, University of Bristol.

Appointments

2006-7: Nationally appointed Interface Fellow in Head & Neck Surgery

2005-6: Royal College of Surgeons of England H&N Research Fellowship

2001-6: Specialist Registrar Oral & Maxillofacial Surgery – Mersey Rotation
National Training Number MER/061/003/N CCT in Oral & Maxillofac. Surgery.

1999-2001: Basic Surgical Training:  West of Scotland Deanery (Comprising General Surgery, Orthopaedic Surgery, Plastic Surgery, ENT)

1998-9: Pre-Registration House Officer Posts: Glasgow Royal and Western Infirmary Glasgow

1991-4: Vocational Training / SHO / Registrar in Oral & Maxillofacial Surgery, RAF Halton, RAF Wroughton, BMH Rinteln Hospitals

Postgraduate Fellowships

Travel Fellowship: Leibinger Prize from EACMFS 2002-3, Memorial Sloan Kettering Cancer Centre, New York,
Sydney Head & Neck Cancer Institute, Royal Prince Alfred Hospital

Research Fellowship: RCSEng Research Fellowship 2004, University of Liverpool 2005-6

Department of Health Fellowship: DoH Genetics in Healthcare Fellowship 2005
Awarded to study tissue banking and translational research in Head & Neck Cancer, MD Anderson Cancer Centre

Sub-specialty Surgical Fellowship: Interface Fellowship: Head & Neck Surgical Oncology
National DoH appointment, awarded July 2006 to Mersey Region.

Royal College Fellowships: FDS RCSEng 1993
FRCS (CSiG) RCPSGlasg 2000
FRCS (OMFS) Intercollegiate 2005

Committees and Council Positions

International:
Nominated  to the Council of The International Academy of Oral Oncology 2010-15

National:
National Working Party for Improving Recruitment to Interventional Trials
National Cancer Research Institute: Correlative Science CSG & Emerging technologies subgroup.
National Cancer Research Institute: NCRI Head and Neck Oncology CSG
National Cancer Research Institute: H&N  Surgery and Localised Therapies Subgroup
Royal College of Surgeons of England Academic and Research Committee: representative for Oral & Maxillofacial Surgery
BAOMS Research sub-committee

Regional:
Liverpool Experimental Cancer Medicine Management Committee
Liverpool Cancer Trials Unit Steering Committee
AHNOG Chair
R&D Board, University Hospital Aintree

Brown J S, Shaw R J. Reconstruction of the maxilla and midface. Lancet Oncology. In Press July 2010

Shaw R, Omar M M, Rokadiya S, Kogera F, Lowe D, Liloglou T, Homer J, Hall G, Field  J K, Risk J M.
Cytoglobin is up-regulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer
Br J Cancer. 2009 Jul 7;101(1):139-44. 

Greenhalgh J, Bagust A, Boland A, Fleeman N, McLeod C, Dundar Y, Proudlove C ,Shaw R. Cetuximab for metastatic and/or recurrent squamous cell carcinoma of the head and neck (SCCHN): A Single Technology Appraisal.
Health Technology Assessment. 2010: 13(3): 49-54

G L Hall, R J Shaw, E Field, S N Rogers, D N Sutton, J A Woolgar, D Lowe, T Liloglou, J K Field, J M Risk
p16 promoter methylation predicts malignant transformation in oral epithelial dysplasia.
Cancer Epidemiol Biomarkers Prev. 2008 ;17(8):2174-9.

R J Shaw, E K Akufo-Tetteh, J M Risk, J K Filed, T Liloglou. Methylation enrichment pyrosequencing: combining the specificity of MSP with validation by pyrosequencing.  Nucleic Acids Res 2006;34(11):e78. 

R J Shaw, T Liloglou, S N Rogers, J S Brown, E D Vaughan, D Lowe, J K Field, J M Risk Promoter methylation of P16, RARbeta, E-Cadherin, Cytoglobin & CyclinA1 in oral squamous cell carcinoma: quantitative evaluation by pyrosequencing. * Br J Cancer. 2006;94(4):561-8.

Schache A, Hall G, Woolgar J A, Nikolaidis G, Triantafyllou A, Lowe D, Risk J M, Shaw R,  Liloglou T
Quantitative promoter methylation differentiates Carcinoma ex Pleomorphic Adenoma from Pleomorphic Adenoma of the Salivary Glands.(In Correction)

Ho M,  Houghton L,  Gilmartin E, Jackson S, Lancaster J, Jones T, Blackburn T, Homer J, Ascott F, Shaw R J.
Outcomes following pharyngolaryngectomy reconstruction with the anterolateral thigh (ALT) free flap. Br J Oral Maxillofac Surg. Accepted June 2010

Brown J S, Shaw R J. Reconstruction of the maxilla and midface. Lancet Oncology. In Press Jun 2010

Shaw R, Robinson M. The increasing clinical relevance of human papillomavirus infection in oropharyngeal cancer.
Br J Oral Maxillofac Surg. Accepted June 2010

Robinson M, Sloan P, Shaw R. Refining the diagnosis of oropharyngeal squamous cell carcinoma.
Oral Oncol. 2010 Jul;46(7):492-6

Shaw R, Omar M M, Rokadiya S, Kogera F, Lowe D, Liloglou T, Homer J, Hall G, Field  J K, Risk J M.
Cytoglobin is up-regulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer
Br J Cancer. 2009 Jul 7;101(1):139-44.

Shaw R, Lowe D, Woolgar  J, Brown J S, Vaughan E D, Evans C, Lewis-Jones H, Hanlon R, Hall G, Rogers S N.
Extracapsular spread in oral squamous cell carcinoma Head Neck Head Neck. 2010 Jun;32(6):714-22.

Rogers SN, Brown JS, Woolgar JA, Lowe D, Magennis P, Shaw RJ, Sutton D, Errington D, Vaughan D.
Survival following primary surgery for oral cancer. Oral Oncol. 2009 Mar 45(3):201-11. 

Shaw RJ, McGlashan G, Woolgar JA, Lowe D, Brown JS, Vaughan ED, Rogers SN Squamous Cell Carcinoma of the Buccal Mucosa: The Prognostic Importance of Site Br J Oral Maxillofac Surg. 2009 Jul;47(5):356-9

Shaw R J Brown J S Osteomyocutaneous deep circumflex iliac artery perforator flap in the reconstruction of midface defect with facial skin loss Microsurgery.  2009 Mar 9;29(4):299-302  

Batstone MD, Lowe D, Shaw RJ, Brown JS, Vaughan ED, Rogers SN. Passive versus active drainage following neck dissection: a non-randomised prospective study. Eur Arch Otorhinolaryngol. 2009 Jan;266(1):121-4.

Shaw R, Batstone M D, Blackburn T K,  Brown J S. Leading Article: The anterolateral thigh flap in head and neck reconstruction: “Pearls and pitfalls” Br J Oral Maxillofac Surg  2010 Jan;48(1):5-10

Shaw R, Batstone M D, Blackburn T K, Brown J S. Pre-operative Doppler assessment of perforator anatomy in the anterolateral thigh flap. Br J Oral Maxillofac Surg – epub 15 Sep 2009

Greenhalgh J, Bagust A, Boland A, Fleeman N, McLeod C, Dundar Y, Proudlove C , Shaw R. Cetuximab for metastatic and/or recurrent squamous cell carcinoma of the head and neck (SCCHN): A Single Technology Appraisal. Health Technology Assessment. 2010: 13(3): 49-54 Cetuximab for metastatic and/or recurrent squamous cell carcinoma of the head and neck (SCCHN): A Single Technology Appraisal. PharmacoEconomics 2010: Vol 28 (6) 439-448

Katre C, Shaw R, Triantafylou S, Brown J. Inferior Alveolar Nerve damage caused by the bone wax in third molar surgery.
Int J Oral Maxillofac Surg. 2010 May;39(5):511-3

Brown J S, Bekiroglu F, Shaw R J. The indications for the scapular flap in head and neck reconstruction.
Br J Oral Maxillofac Surg. 2010 Jul;48(5):331-7

G L Hall, R J Shaw, E Field, S N Rogers, D N Sutton, J A Woolgar, D Lowe, T Liloglou, J K Field, J M Risk
p16 promoter methylation predicts malignant transformation in oral epithelial dysplasia. Cancer Epidemiol Biomarkers Prev. 2008 ;17(8):2174-9.

R J Shaw, G L Hall, D Lowe, T Liloglou, J K Field, P Sloan, J M Risk The role of pyrosequencing in head and neck cancer epigenetics: correlation of quantitative methylation data with gene expression. Arch Otolaryngol Head Neck Surg 2008 Mar;134(3):251-6.

Katre C, Shaw R, Batstone M, Brown J. Rescue of anterolateral thigh flap with absent perforators using  anteromedial thigh flap.
Br J Oral Maxillofac Surg. 2008 Jun;46(4):334-5

R J Shaw, G L Hall, D Lowe, N L Bowers, T Liloglou,  J K Field, J A Woolgar,  J M Risk CpG island methylation phenotype (CIMP) in oral cancer: associated with a marked inflammatory response and less aggressive tumour biology.
Oral Oncol. 2007 Oct;43(9):878-86 

R J Shaw, G L. Hall, J A Woolgar, D Lowe, S N. Rogers, J K. Field, T Liloglou, J M Risk Quantitative methylation analysis of resection margins and lymph nodes in oral squamous cell carcinoma. Br J Oral Maxillofac Surg. 2007 Dec;45(8):617-22

R J Shaw, E K Akufo-Tetteh, J M Risk, J K Filed, T Liloglou. Methylation enrichment pyrosequencing: combining the specificity of MSP with validation by pyrosequencing.  Nucleic Acids Res 2006;34(11):e78  

R J Shaw, T Liloglou, S N Rogers, J S Brown, E D Vaughan, D Lowe, J K Field, J M Risk Promoter methylation of P16, RARbeta, E-Cadherin, Cytoglobin & CyclinA1 in oral squamous cell carcinoma: quantitative evaluation by pyrosequencing. * Br J Cancer. 2006;94(4):561-8

E Thomas, R J Shaw and J M Risk Monitoring of circulating tumour-associated DNA as a prognostic tool for oral squamous cell carcinoma. Br J Cancer 2005:93(8):960

R J Shaw, A Sutton, J I Cawood, R A Howells, D Lowe, S N Rogers, J S Brown, E D Vaughan Oral Rehabilitation after treatment for head and neck malignancy. Head Neck 2005; 27(6): 459-470  

Shaw R J, Brown JS, Woolgar JA, Lowe D, Rogers SN, Vaughan ED The influence of the pattern of mandibular invasion on recurrence in oral squamous cell carcinoma. Head  Neck Oct 2004;26(10):861-869 

R J Shaw, A N Kanatas, D Lowe, J S Brown, S N Rogers, E D Vaughan Comparison of miniplates and reconstruction plates in mandibular reconstruction.

R J Shaw, A N Kanatas, D Lowe, J S Brown, S N Rogers, E D Vaughan. Head Neck 2004; 26(5):456-463  RJ Shaw, D N Sutton, J S Brown, J I Cawood Further malignancy in field change adjacent to osseointegrated implants. Int J Oral Maxillofacial Surg 2004;33(4)353-355

Shaw RJ, Richardson D, McMahon S Conservative Management of Otitis Media in Cleft Palate. J Cranio Maxillofac Surg 2003;31,316-320.

Shaw R J, Negus T W, Mellor T K A prospective clinical evaluation of the longevity of resorbable sutures in oral mucoa.  Br J Oral Maxillofac Surg 1996;34(3): 252-254

Shaw R J, Forner L, Butterworth C, Jansen E, Hillerup S, Nutting C, Overgaard J. Randomised controlled trials in HBO: "a call to arms" for HOPON & DAHANCA-21. Accepted Br J Oral Maxillofac Surg Nov 2009

Shaw R, Robinson M.
The increasing clinical relevance of human papillomavirus infection in oropharyngeal cancer.
Br J Oral Maxillofac Surg. Accepted June 2010

Robinson M, Sloan P, Shaw R.
Refining the diagnosis of oropharyngeal squamous cell carcinoma.
Oral Oncol. 2010 Jul;46(7):492-6

Shaw R J, Pace-Bazan A, Butterworth C.
Invited Review: Contemporary Clinical Management of Oral Squamous Cell Cacinoma.
Perio 2000 In Press

Pace-Bazan A, Shaw R J, Butterworth C.
Invited Review: Oral Rehabilitation following treatment for oral cancer
Perio 2000. In Press

Brown J S, Bekiroglu F, Shaw R J.
Leading Article : The indications for the scapular flap in head and neck reconstruction.
Br J Oral Maxillofac Surg. 2010 Jul;48(5):331-7

Shaw R J, Dhanda J
Leading Article: Hyperbaric Oxygen in the Management of Late Radiation Injury to the Head and Neck. Part I: Treatment
Br J Oral Maxillofac Surg. 2009. In press Jan 2010

Shaw R J, Butterworth C
Leading Article: Hyperbaric Oxygen in the Management of Late Radiation Injury to the Head and Neck. Part II: Prevention
Br J Oral Maxillofac Surg. 2009.  In Press Jan 2010

G L Hall, D Kademani, J M Risk, R J Shaw
Tissue Banking in Head & Neck Cancer
Oral Oncol. 2008 Feb;44(2):109-15   I.F. 2.93

Mishra A, Pandey A, Shaw R J
Initiating tumour banking for translational research: MD Anderson and University of Liverpool experience.
Indian J Cancer. 2007 44(1):17-24

R J Shaw 
Invited Review Paper Head & Neck Oncology: The epigenetics of oral cancer.
Int J Oral Maxillofacial Surg 2006; 35:101-108.

“The Genetics and Epigenetics of Head and Neck Cancer” J Dhanda & R Shaw. In Multimodality Treatment of Head and Neck Cancer. Editor Jaques Bernier. Publication scheduled 2010

“Prognosis & Staging in Head & Neck Cancer” R J Shaw & J S Brown. 2nd Ed “Maxillofacial Surgery” Churchill Livingstone.  Editors: Ward Booth, Schendel, Hausamen. Published 2006 ISBN 978-0443100536