Basic Research > Maintenance of Genome Stability > Dr Carlos Rubbi
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My work has led to the finding that the nucleolus promotes p53 degradation. The importance of this model is that it offers a unified mechanism for p53 induction, since any cell stress that impairs nucleolar function will cause loss of p53 degradation.
My main research interest concerns the elucidation of the molecular details of nucleolar control of p53, and the identification of cancer-specific nucleolar targets that can be exploited for the induction of p53 and apoptosis. I am also interested on chromatin control by p53 in response to DNA damage and its role in DNA repair. I am collaborating with the Boyd, Vlatkovic and Costello groups, making extensive use of both fixed and live cell microscopy. |
Education and qualifications
Appointments
Honours and awards
Rubbi, C.P. & Milner, J. Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresse. EMBO J. 22, 6068-6077 (2003).
Rubbi, C.P. & Milner, J. P53: Guardian of a genome's guardian? Cell Cycle 2, 20-21 (2003).
Rubbi, C.P. & Milner, J. p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage. EMBO J. 22, 975-986 (2003).
Seker, H. et al. UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML. Oncogene 22, 1620-1628 (2003).
Rubbi, C.P. & Milner, J. Analysis of nucleotide excision repair by detection of single-stranded DNA transients. Carcinogenesis 22, 1789-1796 (2001).
Rubbi, C.P. & Milner, J. Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus. Oncogene 19, 85-96 (2000).
Rubbi, C.P. & Milner, J. Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresse. EMBO J. 22, 6068-6077 (2003).
Rubbi, C.P. & Milner, J. P53: Guardian of a genome's guardian? Cell Cycle 2, 20-21 (2003).
Rubbi, C.P. & Milner, J. p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage. EMBO J. 22, 975-986 (2003).
Seker, H. et al. UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML. Oncogene 22, 1620-1628 (2003).
Rubbi, C.P. & Milner, J. Analysis of nucleotide excision repair by detection of single-stranded DNA transients. Carcinogenesis 22, 1789-1796 (2001).
Rubbi, C.P. & Milner, J. Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus. Oncogene 19, 85-96 (2000).
| Biography | Role | Telephone | Location | ||
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Dr Carlos Rubbi | Lecturer in Cancer Biology |  |
+44(0)151 706 4099 | 5th floor, Duncan Building |
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