The Centre's seminars are held every Friday at 1pm in the Cancer Research UK Centre Lecture Theatre. All welcome to attend. The University of Liverpool offers one of the best Ph.D. programmes in the U.K., and has been ranked 4th in a study of completion rates for Ph.D. students at universities by the Higher Education Funding Council for England (HEFCE).
Liverpool CRUK Centre Clinical Fellowship entry has closed for 2012
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Managers from local Cancer Research UK shops have been delighted to receive more than 513 bags worth |
| up to £15,390. Please keep your donations coming in so we can reach our new target of 350 bags. Collection points are in the Centre's foyer, Duncan Building, and DSO office. | |
Many patients and public members work with researcher professionals and clinicians (e.g. doctors, nurses) and get actively involved in the different stages of research and associated activities. Active involvement in clinical research is very different from being a participant in a study. Find out more.
Login - PPI Steering Group Members
27th July - Model, Amanda Harrington, visits the Centre
Professor John Neoptolemos and Dr Sylvie Urbé with Liverpool Riverside MP Louise Ellman. MPs were asked to backing the charity’s bid to make their local region and the UK a thriving environment for medical research. As well as finding out more about the cutting edge research carried out in their region, MPs heard that Cancer Research UK receives no Government funding and relies on the generosity of supporters to fund its life-saving work. Cancer Research UK is calling on the Government to work in partnership with the scientific community to ensure that pioneering new research can be transferred from the lab bench to the patient’s bedside as quickly as possible. Guests heard speeches from host Penny Mordaunt MP, Chair of the All Party Parliamentary Group on Life Sciences, Harpal Kumar, Chief Executive of Cancer Research UK, Anne Milton MP, Parliamentary Under Secretary of State for Public Health and former nurse, and Tony Selman, a patient voice, fundraiser and Cancer Campaigns Ambassador. 15th July - Lifetime Scientific Achievement Award
Presentation of the Joseph Cullen Award at the WCLC opening Ceremony to Professor John Field by the President of IASLC Dr David Gandara, USA. 14th July - Caldies Girls Visit
7th July - Charlotte Completes her Epic Race for Life Season Congratulations and well done to Charlotte Rawcliffe (LCTU) for completing TEN Race for Life events this summer. Charlotte ran the last Race at Knowsley on Wednesday 6 July, accompanied by other members of staff from LCTU. No personal bests were achieved as the girls decided to run in pyjamas, and the rain came down until our final team member crossed the line. Dr Seema Chauhan spoke to around 1,800 women before the Race and welcomed the first runner home. Model Amanda Harrington formed part of the start line with the team. Amanda, who is supporting CRUK, will be coming in to visit the Centre this summer.
Congratulations to Sarah Coupland who has been awarded a Personal Chair. 28th June - PET-CT Scanner Official Opening THe PET-CT Scanner at the Royal Liverpool University Hospital has been officially opened by CEO, Tony Bell and Chair, Judith Greensmith. The £1.8m PET-CT Scanner is the only static scanner in the whole of Merseyside and Cheshire. The scanner provides the latest technology to diagnose certain types of cancer and other diseases.
Well done to all the researchers who took part, paricluarly to Lauren Dodgson who came in 4th. The unstoppable Charlotte Rawcliffe ran races 5 and 6 in her ten-Race series, almost beating her personal best time in the morning, but coming a little further down the field in the afternoon, when she ran as the Pink Panther. That's no mean feat on the hottest day of the year so far, so please show your support by sponsoring her now at. www.justgiving.com/charlotterunsten
21st June - Publication Success Congratulations to Carlos Rubbi, as lead author, with Mark Boyd and Nikolina Vlatkovic of the p53/MDM2 Research Group who have had their paper The nucleolus directly regulates p53 export and degradation accepted for the internationally peer reviewed Journal of Cell Biology. The study shows that p53 stability is directly regulated by the nucleolus rather than by diffusible factors (post-translational modifications or enzymes). http://www.ncbi.nlm.nih.gov/pubmed/21893597 Figure: Nuclear locality of p53 regulation: p53 decay by protein synthesis inhibition in U2Os and NIH3T3 cells.
17th June - Liverpool Carer's Day Emma, with Tom Kearns and Gemma Barnett from LCTU represented the Centre at Liverpool Carer’s Day which was held in St George’s Hall on 17th June. The event attracted about 1,000 visitors. They had the chance to catch up with Stephen Twigg MP and introduced themselves to the new Mayor of Liverpool Cllr Frank Prendergast. |
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Local Race for Life Update Thanks to Elinor Chapman who spoke at the Rhyl Race for Life, Lauren Dodgson at Wigan and to Sarah Lake who spoke at the Chester event. Charlotte Rawcliffe continues with her fabulous fundraising efforts- running at Wrexham, Wigan and Chester. If you haven’t already done so, please sponsor Charlotte at www.justgiving.com/charlotterunsten |
| 14th June - Sarcoma Support Group |
A newly formed Sarcoma Support group for Merseyside and Cheshire met at the Centre on 14th June during National Sarcoma Week. Lindsey Bennister, Chief Executive of Sarcoma UK is pictured with Lead Cancer Nurse, Gill Hamblin and patient representative, Cameron Burry. |
6th June - Sefton Park Race for Life Success
A massive thank you to everyone who came down to Sefton Park yesterday morning. With numbers of participants down all over the country we are delighted to say South Liverpool had MORE runners this year, and there was in excess of 4,000 people there today. Well done to Helen Kalarai for speaking to such a big crowd (and getting a cheer).
There are some great pictures and video, particularly of the start line of researchers, which everyone agreed was a great touch (see links below). Emma Squibb, LEAD Manager, will be trying to recreate the magic at Aintree on 26th June - another big Race day for Liverpool, so please consider coming along, or spread the word about how much fun it is! The event raised over a quarter of a million pounds for CRUK and 4,000+ people were told about our work. Researchers' presence really does make a difference, and so thanks again, from CRUK and from Emma, for giving up your free time.
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Lanashire One Granada Reports Download the special Sefton Park Race for Life Cancer Community Update FUTURE EVENT - PET-CT Scanner Open Day 28th June, 11am-3pm The Royal Liverpool University Hospital is holding an Open Day on 28th June to officially open the PET-CT Scanner. All are welcome to attend from 11am -3pm in the Nuclear Medicine Department in the hospital to meet staff and view the scanner. Light refreshments will be available. For more details please contact Elaine Noonan on 706 4464.
17th May The Race for Life season started in the region on Sunday 15th May at Southport. Jithesh Puthen, Neville Cobbe supported the event which was attended by over 1700 women. The Race was the first of Charlotte Rawcliffe’s “Charlotte Runs Ten”, and she was accompanied by Laura Marsh, also of LCTU. You can sponsor Charlotte by visiting www.justgiving.com/charlottetrunsten 10th May Limbal Juvenile Xanthogranuloma in an Adult http://tvnet.sapo.pt/noticias/video_detalhes.php?id=66733 28th April 19th April 15th April - TeloVac Trial BBC Coverage Video footage: http://www.bbc.co.uk/news/health-13086164 8th April - Publication SuccessCongratulations to Mark Boyd et al for successful acceptance of their publication, MDM2 interacts with NME2 (non-metastatic cells 2,protein), and suppresses the ability of NME2 to negatively regulate cell motilityinto Carcinogenesis. Abstract MDM2 expression, combined with increased p53 expression, is associated with reduced survival in several cancers, but is particularly of interest in renal cell carcinoma (RCC) where evidence suggests the presence of tissue-specific p53/MDM2 pathway defects. We set out to identify MDM2 interacting proteins in renal cells that could act as mediators/targets of MDM2 oncogenic effects in renal cancers. We identified the non-metastatic cells 2, protein; NME2 (NDPK-B, NM23-B/- H2), a nucleoside diphosphate kinase, as an MDM2 interacting protein using both a proteomic-based strategy (affinity chromatography and MS/MS from HEK293 cells) and a yeast two-hybrid screen of a renal carcinoma cell-derived cDNA library. The MDM2-NME2 interaction is highly specific, as NME1 (87.5% amino acid identity) does not interact with MDM2 in yeast. Specific NME proteins display welldocumented cell motility and metastasis suppressing activity. We show that NME2 contributes to motility suppression under conditions where MDM2 is expressed at normal physiological/low levels. However, up-regulation of MDM2 in renal cell carcinoma cells abolishes the ability of NME2 to suppress motility. Significantly, when MDM2 expression is down-regulated in these cells using siRNA, the motilitysuppressing activity of NME2 is rescued, confirming that MDM2 expression causes the loss of NME2 cell motility regulatory function. Thus MDM2 up-regulation in renal cancer cells can act in a dominant manner to abrogate the function of a potent suppressor of motility and metastasis. Our studies identify a novel protein-protein interaction between MDM2 and NME2 which suggests a mechanism that could explain the link between MDM2 expression and poor patient survival in RCC. |
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31st March Health and social care students from Hugh Baird College in Bootle came for a tour of the Centre |
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| 30th March - Scientists Go Back to School Neville Cobbe and Louise Rawling from Daimark Bennett’s lab paid a visit to Pleasant Street School in Clarence Street where they met around 40 children and staff. The children (aged 10/11) all said they knew someone who’d had cancer and named lung, breast and bowel cancer, brain tumours and leukaemia. The children showed a good understanding of the lifestyle factors which can cause cancer, especially smoking. One young man was able to tell us what DNA stands for! Neville and Louise demonstrated strawberry DNA extraction and answered questions such as, “how many cells are in a human body”, and “can you clone a strawberry from that DNA”. |
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26th March Liverpool based researcher Amro Ebbiary visited the Widnes CRUK shop to help behind the till. |
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16th March 27 members of the public visited the Centre on 16th March to find out how they could become involved in volunteering opportunities at the Royal, and at Liverpool Cancer Trials Unit. The visitors heard from Lead Cancer Nurse at the Royal Gill Hamblin, Dr. Seema Chauhan of LCTU, Joan Elmer, the Manager of Sunflowers Cancer Support Centre and local fundraiser Bernie Singleton. The visitors also enjoyed tours of the labs conducted by Dr. Ricardo Nunes Bastos and Dr. Shirley Smith. |
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9th March Emma Squibb, Debbie Devine, Prof Andrea Varro and Dr. Sarah Lake represented the Centre at Liverpool Town Hall on 8th March, at an event held to mark International Women’s Day.
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| 3rd March Dr Steve Royle attended a celebration at Frodsham Community Centre on 2nd March. The CRUK shop in Frodsham was celebrating it’s 20th anniversary, awarding long service medals to six volunteers who have volunteered since the shop opened in 1991. |
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24th February
University benefactor Emeritus Professor David A Price Evan visited the Centre on Thursday 24th February, meeting with
Professor Neoptolemos and Professor Barr.

23rd February - Publication Success
Congratulations to Andrea Varro et al. for their work which has been published in Cancer Cell this month.
Quante M, Tu SP, Tomita H, Gonda T, Wang SS, Takashi S, Baik GH, Shibata W, Diprete B, Betz KS, Friedman R, Varro A, Tycko B, Wang TC. Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.
Cancer Cell. 2011 Feb 15;19(2):257-72.
Abstract
Carcinoma-associated fibroblasts (CAFs) that express a-smooth muscle actin (aSMA) contribute to cancer progression, but their precise origin and role are unclear. Using mouse models of inflammation-induced gastric cancer, we show that at least 20% of CAFs originate from bone marrow (BM) and derive from mesenchymal stem cells (MSCs). aSMA+ myofibroblasts (MFs) are niche cells normally present in BM and increase markedly during cancer progression. MSC-derived CAFs that are recruited to the dysplastic stomach express IL-6, Wnt5a and BMP4, show DNA hypomethylation, and promote tumor growth. Moreover, CAFs are generated from MSCs and are recruited to the tumor in a TGF-ß- and SDF-1a-dependent manner. Therefore, carcinogenesis involves expansion and relocation of BM-niche cells to the tumor to create a niche to sustain cancer progression.
22nd February - Race for Life Launch
Scientists from the Centre have supported Race for Life launch events in Liverpool One and Chester this month. CRUK aims to sign up 1 million women to Race for Life this year. Register at www.raceforlife.org
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16th February - Liverpool City Council's Adult Health and Social Care Select Committee Representatives of Liverpool City Council’s Adult Health and Social Care Select Committee Janet Kent and Mike Marsh visited the centre on Wednesday 16th February, meeting with Professor Neoptolemos, Professor Pettitt and Dr Seema Chauhan before being shown around the Professor Barr’s labs. ![]() |
15th February - Liverpool Centre and PBRU featured on BBC Radio 4
Every year about 8000 people in the UK are diagnosed with pancreatic cancer and the five year survival rate remains depressingly low. Professors John Neoptolemos and Robert Sutton spoke with Dr Mark Porter of BBC Radio 4's Case Notes programme. This will be broadcast tonight (Feb 15th) at 9pm and repeated on Wednesday 16th February at 4.30pm.
Charlotte Runs 10
Deputy Operational Director of Liverpool Cancer Trials Unit, Charlotte Rawcliffe will be running an incredible ten Race for Life events (that's 50k) this summer, to raise funds for CRUK. Charlotte will be running at events in Merseyside, Cheshire and North Wales and would like a member (or members) of staff to run with her at each event. You can show your support by sponsoring Charlotte on her Just Giving page.
http://www.justgiving.com/charlotterunsten
5th February - Liverpool Race for Life Launch
Researchers from the Centre turned out in force despite the weather, to help the CRUK Events Team launch the sign up to Race for Life in Liverpool One on Saturday 5th February 2011. Neville Cobbe, Louise Rawling, Lauren Dodgson, Andrea Linford and Emily Linanne from Liverpool, and Lucy Partington from Aintree helped to sign up over 100 women and girls on the day.
2nd February - DLA Piper Visit

A fundraising group from solicitor’s firm DLA Piper in Liverpool City Centre visited Prof Barr’s labs on Wednesday 2nd February. The group were so impressed with the Centre’s work that they left promising to raise more funds for CR-UK.
25th January - Donation from the Vernon Arms
Alan English (LCTU), Dr Carlos Rubbi, and Emma Squibb visited the Vernon Arms pub, Dale Street, on Friday night to receive a cheque for £850 for Cancer Research UK.
Locals held a fundraising event in December in memory of their friend Brian Lathom.

20th January - Centre receives Freedom of the CIty Honour
The Liverpool Cancer Research UK Centre officially received Freedom Roll of Association of the City at an extraordinary meeting of the City Council yesterday.
All civic accolades formally agreed by the City Council are presented with a prestigious scroll of honour by the Lord Mayor at a special civic reception later in the year.
14th January - Improving Outcomes: a Strategy for Cancer, January 2011
The latest Cancer Strategy has been published by the Department of Health - it can be downloaded here.
Associated documents can be downloaded from the Department of Health's website:
14th January - Publication Success
Congratulations to Joseph Slupsky et al. on having their paper published in Blood; their work on c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells is available to view here:
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/blood-2010-08-301176v1
7th January - Stephen Twigg MP visits Centre
Stephen Twigg, MP for West Derby and Shadow Foreign Office Minister, visited the Centre on Friday 7th January, meeting with Professors Ian Greer, Andrea Varro, Francis Barr, Dr. Seema Chauhan, Dr. Eithne Costello, Mr. Richard Shaw and Laura McCann (Public Affairs Officer) from CRUK. Mr. Twigg heard about the work of the Liverpool Cancer Trials Unit, emerging trends in head and neck cancer, and our research in pancreatic and gastric cancers. Mr Twigg also had an opportunity to learn more about basic science and look around Prof Barr’s labs (pictured below with Andrea Linford). He added details of his visit to his website http://tinyurl.com/5tnrcs4.
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4th January - Publication Success
Congratulations to Francis Barr, Ulrike Gruneberg, Kang Zeng, and Ricardo Nunes Bastos on having their paper published in the Journal of Cell Biology; their work on phosphatase limiting Aurora A's kinase activity during mitosis was also featured in its In Focus section.

In Focus - http://jcb.rupress.org/content/191/7/1221.full
Full Paper - http://jcb.rupress.org/content/191/7/1315.full
Bernie triumphs again!
Bernie Singleton attended the Centre on Friday 17th December with her husband Keith, son Matthew and fellow fundraiser Chris Jones. Following another year of successful fundraising in Wirral and Liverpool, Bernie presented a cheque for over £18,100 to CR-UK. Bernie has asked that her donation is used to help fund basic science research.
