Clinical & Translational Research > Pancreatic Cancer > Professor John Neoptolemos

Professor John Neoptolemos is Professor of Surgery, Head of the Division of Surgery and Oncology, (The Owen and Ellen Evans Chair of Cancer Studies) at the University of Liverpool, and Honorary Consultant Surgeon at the Royal Liverpool University Hospital. John leads one of the most successful clinical and academic surgical programmes in the UK. His specific areas of research are clinical trials of pancreatic cancer; gene therapy, pre-symptomatic diagnosis and prognostic and biological predictors of treatment response to pancreatic cancer; hereditary and chronic pancreatitis and acute pancreatitis.

Professor John Neoptolemos is Director of the Liverpool Cancer Research UK Centre, The Owen and Ellen Evans Chair of Cancer Studies, Professor of Surgery and Head of Division of Surgery and Oncology at the University of Liverpool. He is also an Honorary Consultant Surgeon at the Royal Liverpool University Hospital. Contact Details PA, Debbie Devine - Tel 0151 706 4175 Email: J.P.Neoptolemos@liverpool.ac.uk

John Neoptolemos grew up in London (Stamford Hill Junior School and then Owen’s Grammar School for Boys, in Highbury).

As an undergraduate he studied Natural Sciences and then Philosophy at Cambridge (Cambridge: BA 1973, MA 1976) before completing his clinical undergraduate training at Guys Hospital (Cambridge: MB, BChir 1976).

Following housejobs in London he completed his academic and clinical training in Leicester under Prof. Sir Peter Bell, being awarded a Doctorate in Medicine for his thesis "Effect of surgery on monocyte function in patients with colorectal cancer" (Leicester: MD, 1986).

1981: became a Fellow of the Royal College of Surgeons of England. During this time he spent a year in San Diego, California (1985) with Prof. A Hofmann (the famous biliary gastroenterologist) and also Prof. Babs Moossa (an international pancreas surgeon). His education was completed following training with Prof. Henri Bismuth (Paris) and Prof.Hans Beger (Ulm), international liver and pancreas surgeons respectively.

1987: appointed Senior Lecturer in Surgery at the University of Birmingham, where he refined his clinical and research interests towards pancreatitis and pancreatic cancer.

1990: became a Reader and then in 1994 Professor of Surgery still at the University of Birmingham.

1996: appointed Professor of Surgery and Head of Department of Surgery, University of Liverpool, and Honorary Consultant Surgeon, Royal Liverpool University Hospital, becoming Head of the Division of Surgery and Oncology in 2004.

2005: appointed as Head of the School of Cancer Studies in the University of Liverpool.

Awards include:

Royal College of Surgeons of England USA travelling award (1984)
Rodney Smith Prize, Pancreatic Society of Great Britain and Ireland (1987)
Hunterian Professor of Surgery, Royal College of Surgeons of England (1987-88)
Moynihan Travelling Fellowship, Association of Surgeons of Great Britain & Ireland (1988)
Royal Society of Medicine Travelling Professor (USA) (1989)
British Council sponsored lecture tour of Thai Medical Schools at the invitation of the Royal College of Surgeons of Thailand (1990)
Honorary membership of South African Gastroenterology Society (1991)
Visiting Professor, Medical School, University of Hong Kong (1994)
Eybers Visiting Professor, Medical School, University of Orange Free State, South Africa (1994)
Visiting Professor, Christchurch Medical School, University of Otago, New Zealand (1995)
External Examiner, Chinese University of Hong Kong (1996-1997)
Wilson Wang Visiting Professor, Chinese University of Hong Kong (1997)
Visiting Professor, University of Singapore (1998)
Visiting professor University of Heidelberg, (2002)
The Hirschberg Award for Pancreatic Cancer – American Pancreatic Association (2005)
Honyman Gillespie Lecture, Edinburgh (2007)
Fellow Academy of Medical Sciences (2007)
Pearce Gould Visiting Professor, UCL, London (2008).

Official professional positions include:

Council Member of the United European Gastroenterological Federation (1998-2002) and member of the Scientific Committee (2002 et seq)
Member of the International Committee of the International Association of Pancreatology (1990 et seq) and President (2000-2002)
Scientific Committee of the European Pancreatic Club (1993-94)
Member of Council (1995-98), Secretary (1997-2002), President (2002-2004) and Scientific Committee Representative UEGF (2002 et seq)
Member of the World Council of the International Hepato-Pancreato-Biliary Association (1994-98)
Treasurer and Council of European Digestive Surgery (1995 et seq)
Committee member of the Pancreatic Society of Great Britain & Ireland (1987-90) and President (1994-95)
British Society of Gastroenterology Committee member of the Pancreatic Section (1988-91) and the Surgical Section (1991-93)
Committee member of the Surgical Research Society (1995-98)
President, Liverpool & North West Society of Surgeons (2006-2007).

Research positions include:

National Cancer Research Institute, Committee on Upper GI Cancer, Chairman for Pancreatic Cancer (1999 et seq)
UK Pancreatic Cancer Trials Group, Chairman (1991-95)
European Study Group for Pancreatic Cancer (ESPAC), Co-secretary (1992 et seq)
National Institutes of Health (NIH) USA, NCI Pancreatic Cancer Progress Review Group (PRG) (2000)
NCI Specialized Programs of Research Excellence (SPORE) for Pancreatic Cancer (2002-3)
North West Regional Research and Development Biomedical Research Committee (2001-2)
The Royal College of Surgeons of England (RCSEng), Advisor to Research Board (2001 et seq)
MRC-RCSEng Clinical Research Fellowships, Joint Panel, RCSEng representative (2001 et seq)
Netherlands Organisation for Health Research and Development Referee (2002)
Deutsche Krebshilfe:Cancer Centres Advisory Board (2006 et seq)
Panel of Academic Advisers for the Commonwealth Scholarship Commission (2007 et seq)
Cancer Research UK: Science Strategy Advisory Group (2008 et seq)
Member, College of Experts: National Coordinating Centre for (2008 et seq)
Health Technology Assessment (NCCHTA)
Member, Evaluation Committee: French National Cancer Institute (2010 et seq).

Neoptolemos JP, Carr-Locke DL, Fossard DP.  Results of a prospective randomised study of pre-operative endoscopic sphincterotomy versus surgery alone for common bile duct stones. British Medical Journal 1987; 294:470-474.

Neoptolemos JP, Carr-Locke DL, London NJM, Bailey I, James D, Fossard DP.  Results of a prospective randomized trial of ERCP and endoscopic sphincterotomy in acute gallstone pancreatitis. Lancet 1988; ii: 979-983.

Barton CM, Staddon SL, Hughes CM, Hall PA, 0'Sullivan C, Kloppel G, Theis B, Russell C, Neoptolemos JP, Williamson RCN, Lane DA, Lemoine NR.  Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.  British Journal of Cancer 1991; 64: 1076-1082.

MacDonald F, Morton D, McKeown C, Neoptolemos JP, Keighley MRB, Hulten M.  Predictive diagnosis of familial adenomatous polyposis by molecular markers in a defined population.  British Medical Journal 1992; 304: 869-87.

Bradley E and Members of the Atlanta International Symposium.  A clinically based classification system for acute pancreatitis.  Archives of Surgery 1993; 128:586-590.

Gray I, Phillips SMA, Lee SJ, Neoptolemos JP, Weissembach J, Spurr NK.  Loss of chromosomal region 10q23-q25 in prostate cancer.  Cancer Research 1995; 55:4800-4803.

Neoptolemos JP, Kemppainen EA, Mayer JM, Fitzpatrick JM, Raraty MGT, Slavin J, Beger H-G, Hiettaranta AJ, Puolakkainen PA. A multicentre study of early prediciton ofseverity in acute pancreatitis by urinary trypsinogen activation peptide. Lancet 2000; 355: 1955-1960.

Pfützer RH, Barmada MM, Brunskil APJ, Finch R, Hart PS, Neoptolemos J, Furey WF, Witcomb DC.  SPINK1/PSTI Polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis.  Gastroenterology 2000; 119: 615-623.

Neoptolemos JP, Dunn JA, Moffitt DD, Almond J, Link K, Beger H, Bassi C, Falconi M, Pederzoli P, Dervenis C, Fernandez-Cruz, Lacaine F, Pap A, Spooner D, Kerr DJ, Friess H and Büchler M, for the members of the European Study Group for Pancreatic Cancer (ESPAC).  ESPAC-1: A European, Randomized Controlled Study of Adjuvant Chemoradiation and Chemotherapy in Resectable Pancreatic Cancer.  Lancet 2001; 358: 1576-85.

Roche CJ, Hughes ML, Garvey CJ, Campbell F, White DA, Jones L, Neoptolemos JP. CT and pathologic assessment of prospective nodal staging in patients with ductal adenocarcinoma of the head of the pancreas. American Journal of Roentgenology 2003; 180: 475-80.

Hahn SA, Greenhalf B, Ellis I, Sina-Frey M, Rieder H, Korte B, Gerdes B, Kress R, Ziegler A, Raeburn JA, Campra D, Grutzmann R, Rehder H, Rothmund M, Schmiegel W, Neoptolemos JP, Bartsch DK.. BRCA2 germ line mutations in familial pancreatic carcinoma.  Journal of the National Cancer Institute, 2003; 95: 214-221.

Shekouh AR, Thompson CC, Prime W, Campbell F, Hamlett J,  Herrington CS, Lemoine NR, Crnogorac-Jurcevic T, Büchler MW, Friess H, Neoptolemos JP,  Pennington SR, Costello E. Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma. Proteomics, 2003; 3:1988-2001.

Neoptolemos JP, Stocken DD, Friess H, Bassi C, Dunn JA, Hickey H, Beger H, Fernandez-Cruz L, Dervenis C, Lacaine F, Falconi M, Pederzoli P, Pap A, Spooner D, Kerr DJ, Büchler MW for the members of the European Study Group for Pancreatic Cancer (ESPAC).  A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer.  New England Journal of Medicine 2004; 350(12):1200-1210.

Howes N, Lerch MM, Greenhalf W, Stocken DD, Ellis I, Simon P, Truninger K, Ammann R, Cavallini G, Charnley RM, Uomo G, Delhaye M, Spicak J, Drumm B, Jansen J, Mountford R, Whitcomb DC, Neoptolemos JP; European Registry of Hereditary Pancreatitis and Pnacreatic Cancer (EUROPAC).  Clinical and genetic characteristics of hereditary pancreatitis in Europe.  Clinical Gastroenterology and Hepatology 2004; 2(3):252–261.

Jones LE, Humphreys MJ, Campbell F, Neoptolemos JP, Boyd MT. Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer: increased expression of matrix matelloproteinase-7 predicts poor survival. Clinical Cancer Research 2004; 10(8):2832-2845.

Yan L, McFaul C, Howes N, Leslie J, Lancaster G, Wong T, Threadgold J, Evans J, Gilmore I, Smart H, Lombard M, Neoptolemos J, Greenhalf W.  Molecular anaylsis to detect pancreatic ductal adenocarcinoma in high risk groups.  Gastroenterology 2005; 128:2124-2130.

Vimalachandran D, Greenhalf W, Thompson C, Lüttges J, Prime W, Campbell F, Dodson A, Watson R, Crnogorac-Jurcevic T, Lemoine N, Neoptolemos J, Costello E. High nuclear S100A6 (calcyclin) is significantly associated with poor survival in pancreatic cancer patients. Cancer Research 2005; 65(8):3218-25

Crnogorac-Jurcevic T, Gangeswaran R, Bhakta V, Capurso G, Lattimore S, Akada M, Sunamura M, Prime W, Campbell F, Brentnall TA, Costello E, Neoptolemos J, Lemoine NR. Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma. Gastroenterology 2005; 129(5):1454-63.

McFaul CD, Greenhalf W, Earl J, Howes N, Neoptolemos JP for the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC), Kress R, Sina-Frey M, Rieder H, Hahn SA, Bartsch DK, for the German national Case Collecton for Familial Pancreatic Cancer (FaPaCa).  Anticipation in familial pancreatic cancer.  Gut 2006; 55:252-258.

Sultana A, Tudur Smith C, Cunningham D, Starling N, Neoptolemos JP, Ghaneh P. Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer. Journal of Clinical Oncology 2007 20; 25(18):2607-15.

Slater EP, Amrillaeva V, Fendrich V, Bartsch DK on behalf of FaPaCa; Earl J, Vitone LJ, Neoptolemos JP, Greenhalf W on behalf of Europac. Absence of the palladin P239S mutation in European pancreatic cancer families EUROPAC and FaPaCa. PLoS Medicine, 2007; 4(4):e164.

Brand RE, Lerch MM, Rubinstein WS, Neoptolemos JP, Whitcomb DC, Hruban RH, Brentnall TA, Lynch HT, Canto MI, Participants of the Fourth International Symposium of Inherited Diseases of the Pancreas. Recent advances in Clinical Practice.  Advances in counselling and surveillance of patients at risk for pancreatic cancer. Gut, 2007; 56:1460-1469.

Yan L, Tonack, S, Smith R, Dodd S, Jenkins RE, Kitteringham N, Greenhalf W, Ghaneh P, Neoptolemos JP, Costello E.  Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling date for pancreatic cancer.  J Proteome Res 2009 8(1):142-148. 

Neoptolemos JP, Stocken DD, Tudur Smith C, Bassi C, Ghaneh P, Owen E, Moore M, Padbury R, Doi R, Smith D, Büchler MW for the European Study Group of Pancreatic Cancer. Adjuvant 5-Fluorouracil and Folinic Acid versus Observation for Pancreatic Cancer: Composite Data from the ESPAC-1 and -3(v1) Trials. British Journal of Cancer 2009;100(2):246-50.

Carter R, Stocken DD, Ghaneh P, Bramhall SR, Olah A, Kelemen D, Bassi C, Friess H, Dervenis C, Spry C, Büchler MW, Neoptolemos JP, for the European Study Group for Pancreatic Cancer (ESPAC). Longitudinal Quality of Life Data can provide Insights on the Impact of Adjuvant Treatment for Pancreatic Cancer – Subset Analysis of the ESPAC-1 Data. International Journal of Cancer 2009;124(12): 2960-5.

Tonack S, Aspinal O’Dea M, Jenkins RE, Elliot V, Murray S, Lane CS, Kitteringham NR, Neoptolemos JP, Costello E.  A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ.  Journal of Proteomics 2009; 73(2):352-6

Cunningham D, Chau I, Stocken DD, Valle JW, Smith D, Steward W, Harper PG, Dunn J, Tudur-Smith C, West J, Falk S, Crellin A, Adab F, Thompson J, Leonard P, Ostrowski J, Eatock M, Scheithauer W, Herrmann R, Neoptolemos JP.  Phase III Randomized Comparison of Gemcitabine Versus Gemcitabine Plus Capecitabine in Patients With Advanced Pancreatic Cancer. J Clin Oncol. 2009;27(33):5513-5518. Epub 2009 Oct 26.

Campbell F, Smith RA, Whelan P, Sutton R, Raraty M, Neoptolemos JP, Ghaneh P. Classification of R1 resections for pancreatic cancer: the prognostic relevance of tumour involvement within 1 mm of a resection margin. Histopathology. 2009;55(3):277-83.

Schröder  C, Jacob A, Tonack S, Radon TP, Sill M, Zucknick M, Rüffer S, Costello E, Neoptolemos  JP, Crnogorac-Jurcevic T, Bauer A, Fellenberg K, Hoheisel JD. Dual-color proteomic profiling of complex samples with a microarray of 810 cancer-related antibodies. Journal of Molecular and Cellular Proteomics 2010; 9(6):1271-80.

Dive C, Smith RA, Garner E, Ward T, George-Smith SS, Campbell F, Greenhalf W, Ghaneh P, Neoptolemos JP. Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer. Br J Cancer. 2010;102(3):577-82.

Ripka S, Neesse A, Riedel J, Bug E, Aigner A, Poulsom R, Fulda S, Neoptolemos J, Greenhalf W, Barth P, Gress TM, Michl P. CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer. Gut. 2010 May 4.

Johnson CD, Berry DP, Harris S, Pickering RM, Davis C, George S, Imrie CW, Neoptolemos JP, Sutton R.  An open randomized comparison of clinical effectiveness of protocol-driven opioid analgesia, celiac plexus block or thoracoscopic splanchnicectomyfor pain management in patients with pancreatic and other abdominal malignancies.  Pancreatology.  2010 Jan 15;9(6):755-763.

Grocock CJ, Rebours V, Delhaye M, Andren-Sandberg A, Weiss FU, Mountford R, Harcus M, Niemczyck E, Vitone L, Dodd S, Joergensen MT, Ammann RW, Schaffalitzky de Muckadell O, Butler JV, Burgess P, Kerr B, Charnley R, Sutton R, Raraty M, Deviere J, Whitcomb D, Neoptolemos J, Levy P, Lerch MM, Greenhalf W. The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families. Gut. 2010;59(3):357-63.

Shukla PJ, Barreto SG, Fingerhut A, Bassi C, Büchler MW, Dervenis C, Gouma D, Izbicki JR, Neoptolemos J, Padbury R, Sarr MG, Traverso W, Yeo CJ, Wente MN. Toward improving uniformity and standardization in the reporting of pancreatic anastomoses: a new classification system by the International Study Group of Pancreatic Surgery (ISGPS).  Surgery. 2010;147(1):144-53.

Schröder  C, Jacob A, Tonack S, Radon TP, Sill M, Zucknick M, Rüffer S, Costello E, Neoptolemos  JP, Crnogorac-Jurcevic T, Bauer A, Fellenberg K, Hoheisel JD. Dual-color proteomic profiling of complex samples with a microarray of 810 cancer-related antibodies. Journal of Molecular and Cellular Proteomics 2010; 9(6):1271-80.

Dive C, Smith RA, Garner E, Ward T, George-Smith SS, Campbell F, Greenhalf W, Ghaneh P, Neoptolemos JP. Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer. Br J Cancer. 2010;102(3):577-82.

Raraty MGT, Halloran CM, Dodd S, Ghaneh P, Connor S, Evans J, Sutton R, Neoptolemos JP.  Minimal Access Retroperitoneal Pancreatic Necrosectomy – Improvement in morbidity and mortality with a less invasive approach.  Annals of Surgery 2010; 251(5):787-93.

 Ripka S, Neesse A, Riedel J, Bug E, Aigner A, Poulsom R, Fulda S, Neoptolemos J, Greenhalf W, Barth P, Gress TM, Michl P. CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer. Gut. 2010 May 4.

 Slater EP, Langer P, Niemczyk E, Strauch K, Butler J, Habbe N, Neoptolemos J, Greenhalf W, Bartsch DK. PALB2 mutations in European familial pancreatic cancer families. Clin Genet. 2010 Mar 18. [Epub ahead of print].

Yan L, Tonack, S, Smith R, dodd S, Jenkins RE, Kitteringham N, Greenhalf W, Ghaneh P, Neoptolemos JP, Costello E.  Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling date for pancreatic cancer.  J Proteome Res 2009 8(1):142-148. 

Neoptolemos JP, Stocken DD, Tudur Smith C, Bassi C, Ghaneh P, Owen E, Moore M, Padbury R, Doi R, Smith D, Büchler MW for the European Study Group of Pancreatic Cancer. Adjuvant 5-Fluorouracil and Folinic Acid versus Observation for Pancreatic Cancer: Composite Data from the ESPAC-1 and -3(v1) Trials. British Journal of Cancer 2009;100(2):246-50.

Carter R, Stocken DD, Ghaneh P, Bramhall SR, Olah A, Kelemen D, Bassi C, Friess H, Dervenis C, Spry C, Büchler MW, Neoptolemos JP, for the European Study Group for Pancreatic Cancer (ESPAC). Longitudinal Quality of Life Data can provide Insights on the Impact of Adjuvant Treatment for Pancreatic Cancer – Subset Analysis of the ESPAC-1 Data. International Journal of Cancer 2009;124(12): 2960-5.
Sakka N, Smith RA, Whelan P, Ghaneh P, Sutton R, Raraty M, Campbell F, Neoptolemos JP. A Preoperative Prognostic Score for Resected Pancreatic and Periampullary Neuroendocrine Tumours.Pancreatology 2009; 9(5):567-576
Sultana A, Shore S, Raraty MG, Vinjamuri S, Evans JE, Tudur Smith C, Lane S, Chauhan S, Bosonnet L, Garvey C, Sutton R, Neoptolemos JP, Ghaneh P. Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I131 KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma. BMC Cancer. 2009; 9(1):66.

Smith RA, Bosonnet L, Raraty M, Sutton R, Neoptolemos JP, Campbell F, Ghaneh P. Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma. Am J Surg. 2009; 197(4):466-72.

Tonack S, Aspinall-O'Dea M, Neoptolemos JP, Costello E. Pancreatic Cancer: Proteomic Approaches to a Challenging Disease. Pancreatology. 2009 Aug 4;9(5):567-576. [Epub ahead of print]

Tonack S, Aspinal O’Dea M, Jenkins RE, Elliot V, Murray S, Lane CS, Kitteringham NR, Neoptolemos JP, Costello E.  A technically detailed and pragmatic protocol for quantitative serum proteomics using iTRAQ.  Journal of Proteomics 2009; 73(2):352-6

Cunningham D, Chau I, Stocken DD, Valle JW, Smith D, Steward W, Harper PG, Dunn J, Tudur-Smith C, West J, Falk S, Crellin A, Adab F, Thompson J, Leonard P, Ostrowski J, Eatock M, Scheithauer W, Herrmann R, Neoptolemos JP.  Phase III Randomized Comparison of Gemcitabine Versus Gemcitabine Plus Capecitabine in Patients With Advanced Pancreatic Cancer. J Clin Oncol. 2009 Nov 20;27(33):5513-5518. Epub 2009 Oct 26.

Campbell F, Smith RA, Whelan P, Sutton R, Raraty M, Neoptolemos JP, Ghaneh P. Classification of R1 resections for pancreatic cancer: the prognostic relevance of tumour involvement within 1 mm of a resection margin. Histopathology. 2009 Sep;55(3):277-83.

 Nedjadi T, Kitteringham N, Campbell F, Jenkins RE, Park BK, Navarro P, Ashcroft F, Tepikin A, Neoptolemos JP, Costello E. S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. Br J Cancer. 2009 Oct 6;101(7):1145-54. Epub 2009 Sep 1.

Halloran CM, Ghaneh P, Connor S, Sutton R, Neoptolemos JP, Raraty MG. Carbohydrate antigen 19.9 accurately selects patients for laparoscopic assessment to determine resectability of pancreatic malignancy. Br J Surg. 2008; 95(4):453-9.

Butturini G, Stocken DD, Wente MN, Jeekel H, Klinkenbijl JHG, Bakkevold KE, Takada T, Amano H, Dervenis C, Bassi C, Büchler MW, Neoptolemos JP, on behalf of the Pancreatic Cancer Meta-analysis Group. The influence of resection margins and treatment on survival for patients with pancreatic cancer within a meta-analysis of randomized controlled trials. Archives of Surgery 2008; 143(1):75-83.

Smith R, Sutton R, Evans J, Healey P, Garvey C, Hughes M, Rararty M, Campbell F, Neoptolemos JP. The platelet-lymphocyte ratio improves the predictive value of serum CA19-9 levels in determining patient selection for staging laparoscopy in suspected periampullary cancer.  Surgery 2008; 143(5): 658-66.

Murphy J, Criddle D, Sherwood M, Chvanov, Mukherjee R, McLaughlin E, Booth D, Gerasimenko J, Raraty M, Ghaneh P, Neoptolemos J, Gerasimenko O, Tepikin A, Green G, Reeve J, Petersen O, Sutton R.  Direct Activation of Cytosolic Ca2_ Signaling and Enzyme Secretion by Cholecystokinin in Human Pancreatic Acinar Cells. Gastroenterology 2008; 135:632–641
van Santvoort HC, Bollen TL, Besselink MG, Banks PA, Boermeester MA, van Eijck CH, Evans J, Freeny PC, Grenacher L, Hermans JJ, Horvath KD, Hough DM, Laméris JS, van Leeuwen MS, Mortele KJ, Neoptolemos JP, Sarr MG, Vege SS, Werner J, Gooszen HG.  Describing Peripancreatic Collections in Severe Acute Pancreatitis Using Morphologic Terms: An International Interobserver Agreement Study. Pancreatology. 2008;8(6):593-599. Epub 2008 Oct 13.

Smith RA, Dajani K, Dodd S, Whelan P, Raraty M, Sutton R, Campbell F, Neoptolemos JP, Ghaneh P. Preoperative resolution of jaundice following biliary stenting predicts more favourable early survival in resected pancreatic ductal adenocarcinoma. Ann Surg Oncol. 2008; 15(11): 3138-46.
Sultana A, Ghaneh P, Cunningham D, Starling N, Neoptolemos JP, Smith CT. Gemcitabine based combination chemotherapy in advanced pancreatic cancer-indirect comparison.  BMC Cancer. 2008 Jul 8;8:192.

Smith RA, Bosonnet L, Ghaneh P, Raraty M, Sutton R, Campbell F, Neoptolemos JP.  Preoperative CA19-9 levels and lymph node ratio are independent predictors of survival in patients with resected pancreatic ductal adenocarcinoma. Dig Surg. 2008; 25(3):226-32. Epub 2008 Jun 24.

Smith RA, Ghaneh P, Sutton R, Raraty M, Campbell F, Neoptolemos JP. Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio. J Gastrointest Surg. 2008 Aug;12(8):1422-8. Epub 2008 Jun 10.

Al-Sarireh B, Ghaneh P, Gardner-Thorpe J, Raraty M, Hartley M, Sutton R, Neoptolemos JP.  Complications and follow-up after pancreas-preserving total duodenectomy for duodenal polyps.  Br J Surg 2008; 95(12):1506-1511.

Nur U, Rachet B, Parmar MK, Sydes MR, Cooper N, Lepage C, Northover JM, James R, Coleman MP; AXIS collaborators. No socioeconomic inequalities in colorectal cancer survival within a randomised clinical trial. Br J Cancer. 2008 Dec 2;99(11):1923-8.

Diener MK, Knaebel HP, Witte ST, Rossion I, Kieser M, Buchler MW, Seiler CM; DISPACT Trial Group. DISPACT trial: a randomized controlled trial to compare two different surgical techniques of DIStal PAnCreaTectomy - study rationale and design. Clin Trials. 2008;5(5):534-45.

Wente MN, Claudio Bassi, Christos Dervenis, Fingerhut A, Gouma DJ, Izbicki JR, Neoptolemos JP, Padbury RT, Sarr MG, Traverso LW, Yeo, CJ, Büchler MW. Delayed gastric emptying after pancreatic surgery – A suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Delayed gastric emptying (DGE) after pancreatic surgery: A suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery 2007; 142(5): 761-8.

Wente MN, Veit JA,Claudio Bassi, Christos Dervenis, Fingerhut A, Gouma DJ, Izbicki JR, Neoptolemos JP, Padbury RT, Sarr MG, Traverso LW, Yeo, CJ, Büchler MW. Postpancreatectomy hemorrhage (PPH) – An International Study Group of Pancreatic Surgery (ISGPS) definition. Surgery 2007; 142(1):20-5.

Sultana A, Tudur Smith C, Cunningham D, Starling N, Neoptolemos JP, Ghaneh P. Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer. Journal of Clinical Oncology 2007 20; 25(18):2607-15.

Sultana A, Tudur Smith C, Cunningham D, Starling N, Tait D, Neoptolemos JP, Ghaneh P. Meta-analyses on the management of locally advanced pancreatic cancer using radiation/combined modality therapy. British Journal of Cancer 2007; 96: 1183-90.

Slater EP, Amrillaeva V, Fendrich V, Bartsch DK on behalf of FaPaCa; Earl J, Vitone LJ, Neoptolemos JP, Greenhalf W on behalf of Europac. Absence of the palladin P239S mutation in European pancreatic cancer families EUROPAC and FaPaCa. PLoS Medicine, 2007; 4(4):e164.

Brand RE, Lerch MM, Rubinstein WS, Neoptolemos JP, Whitcomb DC, Hruban RH, Brentnall TA, Lynch HT, Canto MI, Participants of the Fourth Interantional Symposium of Inherited Diseases of the Pancreas. Recent advances in Clinical Practice.  Advances in counselling and surveillance of patients at risk for pancreatic cancer. Gut, 2007; 56:1460-1469.

McFaul CD, Greenhalf W, Earl J, Howes N, Neoptolemos JP for the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC), Kress R, Sina-Frey M, Rieder H, Hahn SA, Bartsch DK, for the German national Case Collecton for Familial Pancreatic Cancer (FaPaCa).  Anticipation in familial pancreatic cancer.  Gut 2006; 55:252-258.

Latchford A, Greenhalf W, Vitone LJ, Neoptolemos JP, Lancaster GA, Phillips RK.  Peutz-Jeghers syndrome and screening for pancreatic cancer.  British Journal of Surgery 2006; 93(12):1446-55.

Earl J, Yan L, Vitone LJ, Risk J, Kemp SJ, McFaul C, Neoptolemos JP, Greenhalf W; European Registry of hereditary Pancreatitis and Familial Pancreatic Cancer; Kress R, Sina-Frey M, Hahn SA, Rieder H, Bartsch DK; German National Case Collection for Familial Pancreatic Cancer.  Evaluation of the 4q32-34 locus in European familial pancreatic cancer.  Cancer Epidemiology Biomarkers Preview 2006; 15(10):1948-55.

Criddle DN, Murphy J, Fistetto G, Barrow S, Tepikin AV, Neoptolemos JP, Sutton R, Petersen OH.  Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis.  Gastroenterology 2006; 130(3):781-93.

Alexakis N, Campbell F, Eardley N, Smart HL, Garvey C, Neoptolemos JP.  T cell lymphoplasmacellular and eosinophilic infiltration of the pancreas with involvement of the gallbladder and duodenum in non-alcoholic duct-destructive chronic pancreatitis. Langenbecks Archives of Surgery 2005; 390(1):32-38

Alderson D, Johnson CD, Neoptolemos JP, Ainley CC, Bennett MK, Campbell F, Charnley RM, Corrie PG, Falk SJ, Foulis AK, Hall RI,  Hacking CN,  Imrie CW,  Kennedy RH, Kingsnorth AN, Lendrum R, Longstaff AJ,  Manson J McK, Mitchell CJ, Russell RCG, Thomas WEG on behalf of the Writing Committee established by the Pancreatic Section of the British Society of Gastroenterology with the participation of the Pancreatic Society of Great Britain & Ireland, the Association of Upper Gastrointestinal Surgeons of Great Britain & Ireland, the Royal College of Pathologists, the Special Interest Group for Gastro-Intestinal Radiology. Guidelines for the management of patients with pancreatic cancer peri-ampullary and ampullary carcinomas.  Gut 2005; 54(Suppl V):v1-v16

Johnson CD, Charnely R, Rowlands B, Carter R, Bassi C, Chalmers A, Imrie CW, Larvin M, Mitchell CJ, Neoptolemos JP, Siriwardena A, Aly E, Butturini G, Kelly J on behalf of the Working Party of the British Society of Gastroenterology, Association of Surgeons of Great Britain & Ireland, Pancreatic Society of Great Britain & Ireland, Association of Upper GI Surgeons of Great Britain & Ireland.  UK Guidelines for the Management of Acute Pancreatitis.  Gut 2005; 54(Suppl III):iii1-iii9

Connor S, Bosonnet L, Alexakis N, Raraty M, Ghaneh P, Sutton R, Neoptolemos JP.  Serum CA 19-9 measurement increases the effectiveness of staging laparoscopy in patients with peri-ampullary malignancy.  Digestive Surgery 2005; 22(1-2):80-85

Connor S, Alexakis N, Raraty M, Ghaneh P, Evans J, Hughes M, Garvey CJ, Sutton R, Neoptolemos JP.  Early and late complications following pancreatic necrosectomy.  Surgery 2005; 137(5):499-505

Lytras D, Connor S, Bosonnet L, Jayan R, Evans J, Hughes M, Garvey CJ, Ghaneh P, Sutton R, Vinjamuri S, Neoptolemos JP.  Positron Emission Tomography does not add to Computed Tomography for the diagnosis and staging of pancreatic cancer.  Digestive Surgery 2005; 22(1-2):55-61

Stocken DD, Büchler MW, Dervenis C, Bassi C, Jeekel H, Klinkenbijl JHG, Bakkevold KE, Takada T, Amano H, Neoptolemos JP on behalf of the Pancreatic Cancer Meta-analysis Group.  Meta-analysis of randomised adjuvant therapy trials for pancreatic cancer.  British Journal of Cancer 2005; 92(8):1372-81

Yan L, McFaul C, Howes N, Leslie J, Lancaster G, Wong T, Threadgold J, Evans J, Gilmore I, Smart H, Lombard M, Neoptolemos J, Greenhalf W.  Molecular anaylsis to detect pancreatic ductal adenocarcinoma in high risk groups.  Gastroenterology 2005; 128:2124-2130.

Vimalachandran D, Greenhalf W, Thompson C, Lüttges J, Prime W, Campbell F, Dodson A, Watson R, Crnogorac-Jurcevic T, Lemoine N, Neoptolemos J, Costello E. High nuclear S100A6 (calcyclin) is significantly associated with poor survival in pancreatic cancer patients. Cancer Research 2005; 65(8):3218-25

Bassi C, Butturini G, Fingerhut A, Yeo C, Izibicki J, Neoptolemos JP, Sarr M, Traverso W, Buchler M, Dervenis C for the International Study Group on Pancreatic Fistula Definition.  Post-operative pancreatic fistula: an International Study Group (ISGPF) definition.  Surgery 2005;138(1):8-13

Bartsch DK, Fendrich V, Slater EP, Sina-Frey M, Rieder H, Greenhalf W, Chaloupka B, Hahn SA, Neoptolemos JP, Kress R. RNASEL germline variants and its associations with pancreatic cancer.  International Journal Cancer 2005; 117(5):718-22.

Bassi C, Stocken DD, Olah A, Friess H, Buckels J, Hickey H, Dervenis C, Dunn JA, Deakin M, Carter R, Ghaneh P, Neoptolemos JP, Büchler MW. The Influence of Surgical Resection and Post-operative Complications on Survival following Adjuvant Treatment for Pancreatic Cancer in the ESPAC-1 Randomized Controlled Trial.  Digestive Surgery 2005; 22(5):353-363.

Cohn JA, Neoptolemos JP, Feng J, Yan J, Jiang Z, Greenhalf W, McFaul C, Mountford R, Sommer SS.  Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers.  Human Mutation 2005; 26(4):303-307.

Crnogorac-Jurcevic T, Gangeswaran R, Bhakta V, Capurso G, Lattimore S, Akada M, Sunamura M, Prime W, Campbell F, Brentnall TA, Costello E, Neoptolemos J, Lemoine NR. Proteomic analysis of chronic pancreatitis and pancreatic adenocarcinoma. Gastroenterology 2005; 129(5):1454-63.

Neoptolemos JP, Stocken DD, Friess H, Bassi C, Dunn JA, Hickey H, Beger H, Fernandez-Cruz L, Dervenis C, Lacaine F, Falconi M, Pederzoli P, Pap A, Spooner D, Kerr DJ, Büchler MW for the members of the European Study Group for Pancreatic Cancer (ESPAC).  A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer.  New England Journal of Medicine 2004; 350(12):1200-1210.

Howes N, Lerch MM, Greenhalf W, Stocken DD, Ellis I, Simon P, Truninger K, Ammann R, Cavallini G, Charnley RM, Uomo G, Delhaye M, Spicak J, Drumm B, Jansen J, Mountford R, Whitcomb DC, Neoptolemos JP; European Registry of Hereditary Pancreatitis and Pnacreatic Cancer (EUROPAC).  Clinical and genetic characteristics of hereditary pancreatitis in Europe.  Clinical Gastroenterology and Hepatology 2004; 2(3):252–261.

Halloran CM, Ghaneh P, Shore S, Greenhalf W, Zumstein L., Wilson D, Neoptolemos JP, Costello E.  5-Fluorouracil or gemcitabine combined with adenoviral-mediated reintroduction of p16INK4A greatly enhanced cytotoxicity in Panc-1 pancreatic adenocarcinoma cells. Journal of Gene Medicine 2004; 6(5):514-25.

Jones LE, Humphreys MJ, Campbell F, Neoptolemos JP, Boyd MT. Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer: increased expression of matrix matelloproteinase-7 predicts poor survival. Clinical Cancer Research 2004; 10(8):2832-2845.

Missiaglia E, Blaveri E, Terris B, Wang YH, Costello E, Neoptolemos JP, Crnogorac-Jurcevic T, Lemoine NR. Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis. International Journal of Cancer 2004; 112(1):100-12.

Alexakis N, Sutton R, Raraty M, Connor S, Ghaneh P, Hughes ML, Garvey C, Evans JC, Neoptolemos JP. Major resection for chronic pancreatitis in patients with vascular involvement is associated with increased postoperative mortality. British Journal of Surgery 2004; 91(8):1020-1026.

Alexakis N, Connor S, Ghaneh P, Raraty M, Lombard M, Smart H, Hughes M, Evans J, Garvey C, Sutton R, Goulden M, Parker C, Neoptolemos JP. Influence of opioid use on surgical and long-term outcome following resection for chronic pancreatitis.  Surgery 2004; 136:600-8.

Criddle DN, Raraty MG, Neoptolemos JP, Tepikin AV, Petersen OH, Sutton R. Ethanol toxicity in pancreatic acinar cells: mediation by non-oxidative fatty acid metabolites.  Proceedings National Academy of Sciences 2004; 101(29): 10738-10743.

McFaul, CD, Vitone LJ, Campbell F, Azadeh B, Hughes ML, Garvey CJ, Ghaneh P, Neoptolemos JP.  Pancreatic hamartoma: two case reports and review of the literature.  Pancreatology 2004; 4(6):533-8.

Doran HE, Bosonnet L, Connor S, Jones L, Garvey C, Hughes M, Campbell F, Hartley M, Ghaneh P, Neoptolemos JP, Sutton R.  Laparoscopy and laparoscopic ultrasound in the surgical evaluation of pancreatic and periampullary tumours.  Digestive Surgery 2004; 21:305-313.

Connor S, Alexakis N, Neal T, Raraty M,Ghaneh P, Evans J, Hughes M, Rowlands P, Garvey CJ, Sutton R, Neoptolemos JP.  Fungal infection but not type of bacterial infection is associated with a high mortality in primary and secondary infected pancreatic necrosis.  Digestive Surgery 2004; 21:297-304.

Grutzmann R, McFaul C, Bartsch DK, Sina-Frey M, Rieder H, Koch R, McCarthy E, Greenhalf W, Neoptolemos JP, Saeger HD, Pilarsky C.  No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma.  Cancer Letters 2004; 214(1):63-8.

Debhri AR, Connor S, Campbell F, Ghaneh P, Sutton R, Neoptolemos JP.  Diagnosis, treatment and outcome of pancreatoblastoma.  Pancreatology 2004; 4(5):441-453.

Connor S, L Bosonnet L, Doran H, Ghaneh P, Alexakis N, Hartley M, Campbell F, Sutton R, Neoptolemos JP. Survival analysis of peri-pancreatic tumours by Lymph node 8a and Lymph node 16 status. British Journal of Surgery 2004; 91(12):1592-9.

Roche CJ, Hughes ML, Garvey CJ, Campbell F, White DA, Jones L, Neoptolemos JP. CT and pathologic assessment of prospective nodal staging in patients with ductal adenocarcinoma of the head of the pancreas. American Journal of Roentgenology 2003; 180: 475-80.

Evans JD, Cornford PA, Dodson A, Neoptolemos JP, Foster CS.  Expression patterns of protein kinase C isoenzymes are characteristically modulated in chronic pancreatitis and pancreatic cancer.
American Journal of Clinical Pathology 2003; 119: 392-402.

Weiß FU, Simon P, Witt H, Mayerle J, Hlouschek V, Zimmer KP, Schnekenburger J, Domschke W, Neoptolemos JP, Lerch MM. SPINK1 Mutations, Phenotype Expression and Onset of Diabetes Mellitus in Patients with Trypsinogen Mutation – associated Pancreatitis.  Journal of Medical Genetics 2003; 40(4):e40.

Hahn SA, Greenhalf B, Ellis I, Sina-Frey M, Rieder H, Korte B, Gerdes B, Kress R, Ziegler A, Raeburn JA, Campra D, Grutzmann R, Rehder H, Rothmund M, Schmiegel W, Neoptolemos JP, Bartsch DK.. BRCA2 germ line mutations in familial pancreatic carcinoma.  Journal of the National Cancer Institute, 2003; 95: 214-221.

Bhatia M, Proudfoot AEI, Wells TNC, Christmas SE, Neoptolemos J, Slavin J.  Treatment with Met-RANTES reduces lung injury in caerulein-induced pancreatitis.  British Journal of Surgery, 2003; 90(6):698-704.

Connor S, Ghaneh P, Raraty M, Sutton R, Rosso E, Garvey CJ, Hughes ML, Evans JC, Rowlands P, Neoptolemos JP.  Minimally invasive retroperitoneal pancreatic necrosectomy.  Digestive Surgery, 2003; 20(4): 270-277.

Bhatia M, Slavin J, Cao Y, Basbaum AI, Neoptolemos JP.  Preprotachykinin-A gene deletion protects mice against acute pancreatitis and associated lung injury.  American Journal of Physiology 2003; 84(5): 830-836.

Crnogorac-Jurcevic T, Missiaglia E, Blaveri E, Gangeswaran R, Jones M, Terris B, Costello E, Neoptolemos J, Lemoine NR. Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression S100 genes is highly prevalent. Journal of Pathology 2003; 201(1):63-74.

Alexakis N, Bosonnet L, Connor S, Ellis I, Sutton R, Campbell F, Hughes M, Garvey C, Neoptolemos JP. Double resection for patients with pancreatic cancer and a second primary renal cell cancer. Digestive Surgery.  2003; 20(5):428-32.

Connor S, Ghaneh P, Raraty M, Rosso E, Hartley MN, Garvey C, Hughes M, McWilliams R, Evans J, Rowlands P, Sutton R, JP Neoptolemos. Increasing age and APACHE II scores are the main determinants of outcome from pancreatic necrosectomy. British Journal of Surgery, 2003;90(12):1542-8

Alexakis N, Ghaneh P, Connor S, Raraty M, Sutton R, JP Neoptolemos. Duodenum-preserving and spleen-preserving total pancreatectomy is a new operation for the treatment of advanced chronic pancreatitis. British Journal of Surgery, 2003;90(11):1401-8

Shekouh AR, Thompson CC, Prime W, Campbell F, Hamlett J,  Herrington CS, Lemoine NR, Crnogorac-Jurcevic T, Büchler MW, Friess H, Neoptolemos JP,  Pennington SR, Costello E. Application of laser capture microdissection combined with two-dimensional electrophoresis for the discovery of differentially regulated proteins in pancreatic ductal adenocarcinoma. Proteomics, 2003; 3:1988-2001.

James RD, Donaldson D, Gray R, Northover JM, Stenning SP, Taylor I; AXIS collaborators (JP Neoptolemos major contributor). Randomized clinical trial of adjuvant radiotherapy and 5-fluorouracil infusion in colorectal cancer (AXIS). British Journal of Surgery. 2003; 90:1200-12.

Kerr DJ, McArdle CS, Ledermann J, Taylor I, Sherlock DJ, Schlag PM, Buckels J, Mayer D, Cain D, Stephens RJ; Medical Research Council's colorectal cancer study group; European Organisation for Research and Treatment of Cancer colorectal cancer study group (JP Neoptolemos major contributor). Intrahepatic arterial versus intravenous fluorouracil and folinic acid for colorectal cancer liver metastases: a multicentre randomised trial. Lancet. 2003; 361(9355):368-73.

Mayer JM, Raraty M, Slavin J, Kemppainen E, Fitzpatrick J, Hietaranta A, Puolakkainen P, Beger HG, Neoptolemos JP.  Serum amyloid A is a better early predictor of severity than C-reactive protien in acute pancreatitis.  British Journal of Surgery 2002; 89: 163-171.

Bhatia M, Brady M, Kang YK, Costello E, Christmas SE, Neoptolemos JP, Slavin J.  MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to caerulein hyperstimulation.  American Journal of Physiology 2002; 282: G77-G85.

Pfützer R, Myers E, Applebaum-Shapiro S, Finch R, Ellis I, Neoptolemos JP, Kant JA, Whitcomb DC.  Novel Cationic Trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis.  Gut 2002; 50: 271-272.

Threadgold J, Greenhalf W, Ellis I, Howes N, Lerch MM, Jansen J, Charnley R, Laugier R, Frulloni L, Attila GO, Delhaye M, Ihse I, Schaffalitzky de Muchadell OB, Andrén-Sandberg Å, Imrie CW, Martinek J, Gress TM, Mountford R, Whitcomb D, Neoptolemos JP.  The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease.  Gut 2002; 50: 675-681.

Brady M, Bhatia M, Christmas S, Boyd MT, Neoptolemos JP, Slavin J.  Expression of the chemokines MCP-1/JE and CINC in early acute pancreatitis.  Pancreas 2002; 25: 260-9.

Shokuhi S, Bhatia M, Christmas S, Sutton R, Neoptolemos JP, Slavin J.  Leveles of the chemokines growth-related oncogene α and epithelial neutrophil-activating protein 78 are raised in patients with severe acute pancreatitis.  British Journal of Surgery 2002; 89: 566-572.

Mayer J, Raraty M, Slavin J, Kemppainen E, Fitzpatrick J, Hietaranta A, Puolakkainen P, Beger H, Neoptolemos J.  Severe acute pancreatitis is related to increased early levels of the activation peptide of pancreatic phospholipase A2 (PROP). Pancreatology 2002; 2: 535-542.

Uhl W, Warshaw A, Imrie C, Bassi C, McKay CJ, Lankisch PG, Carter R, Di Magno E, Banks PA, Whitcomb DC, Dervenis C, Ulrich CD, Satake K, Ghaneh P, Hartwig W, Werner J, McEntee G, Neoptolemos JP, Büchler MW.  IAP Guidelines for the Surgical Management of Acute Pancreatitis.  Pancreatology, 2002; 2: 565-573.

Meier R, Beglinger C, Layer P, Gullo L, Keim V, Laugier R, Friess H, Schweitzer M, Macfie J, Ballmer PE, Bassi C, Miquel GA, Hars’nyi L, Hiesmayr M, Imrie CW, Neoptolemos JP, Plauth M.  ESPEN guidelines on nutrition in acute pancreatitis.  Clinical Nutrition 2002; 21(2):173-183.

Johnson CD, Kingsnorth AN, Imrie CW, McMahon MJ, Neoptolemos JP, McKay C, Toh SKC, Skaife P, Leeder PC, Wilson P, Curtis LD.  Double blind, randomised placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis. Gut 2001; 48: 62-69.

Kemppainen E, Mayer J, Puolakkainen P, Raraty M, Slavin J, Fitzpatrick J, Hietaranta A, Beger H, Neoptolemos JP.  Plasma trypsinogen activation peptide in patients with acute pancreatitis.  British Journal of Surgery 2001; 88: 679-680.

Howes N, Rutherford S, O’Donnell M, Mountford R, Ellis I, Greenhalf W, Whitcomb D, Imrie C, Drumm B, Neoptolemos JP.  A new polymorphsm for the R122H mutation in Hereditary Pancreatitis.  Gut 2001; 48: 247-250.

Ghaneh P, Humphreys M, Greenhalf W, Lemoine NR, Neoptolemos JP.  Adenovirus mediated transfer of wild-type p16INK4 and p53 in pancreatic cancer in vitro and in vivo.  Gene Therapy 2001; 8: 199-208.

Evans JD, Cornford PA, Dodson A, Greenhalf W, Foster CS, Neoptolemos JP. Detailed tissue expression of BCL-2, BAX, BAK, and BCL-X in the normal human pancreas and in chronic pancreatitis, ampullary and pancreatic ductal adenocarcinomas.  Pancreatology 2001; 1: 254-262.

Humphreys M, Ghaneh P, Greenhalf W, Yates J, Campbell F, Clayton TM, Everett P, Huber BE, Richards CA, Ford MJ, Neoptolemos JP.  Hepatic intra-arterial delivery of a retroviral vector expressing the cytosine deaminase gene, controlled by the CEA promotor and intraperitoneal treatment with 5-fluorocytosine suppresses growth of colorectal liver metastases.  Gene Therapy 2001; 8: 1241-7.

Ulrich C and members of the Third International Symposium on Hereditary Diseases.  Pancreatic cancer in hereditary pancreatitis – Consensus guidelines for prevention, screening, and treatment.  Pancreatology  2001; 1: 412-418

Whitcomb DC, Ulrich CD, Lerch MM, Durie P, Neoptolemos JP, Maisonneurve P, Lowenfels AB.  Conference report: Third International Symposium on Inherited Diseases of the Pancreas.  Pancreatology 2001; 1: 419-427.

Ellis I and members of the Consensus Committees of the European Registry of Hereditary Pancreatic Diseases, the Midwest Multi-Center Pancreatic Study Group and the International Association of Pancreatology.  Genetic testing for hereditary pancreatitis: Guidelines for indications, counselling, consent and privacy issues. Pancreatology 2001; 1: 401-411.

Neoptolemos JP, Dunn JA, Moffitt DD, Almond J, Link K, Beger H, Bassi C, Falconi M, Pederzoli P, Dervenis C, Fernandez-Cruz, Lacaine F, Pap A, Spooner D, Kerr DJ, Friess H and Büchler M, for the members of the European Study Group for Pancreatic Cancer (ESPAC).  ESPAC-1: A European, Randomized Controlled Study of Adjuvant Chemoradiation and Chemotherapy in Resectable Pancreatic Cancer.  Lancet 2001; 358: 1576-85.

Neoptolemos JP, Stocken DD, Dunn JA, Almond J, Berger HG, Pederzoli P, Bassi C, Dervernis C, Fernandez-Cruz L, Lacaine F, Buckels J, Deakin M, Adab F, Sutton R, Imrie C, Ihse I, Tihanyi T, Olah A, Pedrazzoli S, Spooner D, Kerr DJ, Friess H, Büchler MW for the members of the European Study Group for Pancratic Cancer (ESPAC).  Influence of resection margins on survival for patients with pancreatic cancer treated by adjuvant chemoradiation and/or chemotherapy within the ESPAC-1 randomized controlled trial. Annals of Surgery 2001; 234: 758-768.

Evans JD, Stark A, Johnson CD, Daniel F, Carmichael J, Buckels J, Imrie CW, Brown P, Neoptolemos JP.  A phase II trial of marimastat in advanced pancreatic cancer.  British Journal of Cancer 2001; 85: 1865-1870.

Neoptolemos JP, Kemppainen EA, Mayer JM, Fitzpatrick JM, Raraty MGT, Slavin J, Beger H-G, Hiettaranta AJ, Puolakkainen PA. A multicentre study of early prediciton ofseverity in acute pancreatitis by urinary trypsinogen activation peptide. Lancet 2000; 355: 1955-1960.

Bhatia M, Brady M, Zagorski J, Christmas SE, Campbell F, Neoptolemos JP, Slavin J. Treatment with neutralising antibody against cytokine-induced neutrophil chemoattractant (CINC) protects rats against acute pancreatitis-associated lung injury. Gut 2000; 47: 838-44.

Pereira SP, Wilkinson ML, Hodgson SV, Rutherford SN, Neoptolemos JP, Hermon Dowling R. A family with hereditary pancreatitis caused by a mutation in the cationic trypsinogen gene. CME Journal of Gastroenterology 2000; 3: 60-61.

Kawesha A, Ghaneh P, Andrén-Sandberg Å, Ögraed D, Skar R, Dawiskiba S, Evans JD, Campbell F, Lemoine N and Neoptolemos JP.  K-ras oncogene subtype mutations are associated with survival but not theexpression of p53, p16INK4a, p21WAF-1, Cyclin D1, erbb-B2 and erbb-B3 in resected pancreatic ductal adenocarcinoma.  International Journal of Cancer 2000; 89: 469-474.

Raraty M, Ward J, Sutton R, Neoptolemos JP, Petersen O.  Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells.  Proceedings of the National Academy of Sciences USA 2000; 97: 13126-13131.

McMillan L, Butcher S, Wallis Y, Neoptolemos JP, Lord JM.  Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: Implications for colon carcinogenesis.  Biochemica et Biophysica Research Communications 2000; 273: 45-49.

Pfützer RH, Barmada MM, Brunskil APJ, Finch R, Hart PS, Neoptolemos J, Furey WF, Witcomb DC.  SPINK1/PSTI Polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis.  Gastroenterology 2000; 119: 615-623.

Evans JD, Hamanaka Y, Olliff SP, Neoptolemos JP.  Tuberculosis of the pancreas presenting as metastatic pancreatic carcinoma.  Acase report and review of the literature.  Digestive Surgery 2000; 17: 183-187.

Cornford PA, Dodson AR, Parsons KF, Desmond AD, Woolfenden A, Fordham M, Neoptolemos JP, Ke Y, Foster CS.  Heat shock protein (HSP) expression independently predicts clinical outcome in prostate cancer.  Cancer Research 2000; 60: 7099-7105.

Lerch MM, Ellis I, WhitcombDC, Keim V, Simon P, Howes N, Rutherford S, Domschke W, Imrie CW, Neoptolemos JP.   Maternal inheritance pattern of Hereditary Pancreatitis in patients with pancreatic carcinoma. Journal of the National Cancer Institute 1999; 91: 723-724.

Chughtai SJ, Crundwell M, Affi E, Cruikshank N, Knowles M, Takle E, Phillips S, Neoptolemos JP, Morton D.  Three regions of interstitial adhesion on the short arm of chromosome 8 in colorectal cancer.  Oncogene 1999; 18: 657-665.

Cornford PA, Evans JD, Dodson AR, Parsons KF, Woolfenden KA, Neoptolemos JP, Foster CS. Protein kinase C isoenzyme patterns characteristically moderated in early prostate cancer. American Journal of Pathology 1999; 154: 137-144.

Primrose JN, Bleiberg H, Daniel F, Van Belle S, Mansi JL, Seymour M, Johnson PW, Neoptolemos JP, Baillet M, Berker K, Berrington A, Brown PD, Miller AW, Lynch KP. Marimastat in recurrent colorectal cancer: exploratory evaluation of biological activity by measurement of carcinoembryonic antigen. British Journal of Cancer 1999; 79: 509-514.

Neoptolemos JP, Ghaneh P, Andrén-Sandberg Å, Bramhall S, Patankar R, Kleibeuker JH, Johnson CD.  Treatment of pancreatic exocrine insufficiency after pancreatic resection: results of a randomised, double-blind, placebo-controlled, cross-over study of high versus standard dose pancreatin.  International Journal of Pancreatology 1999; 25: 171-180.

Jones L, Russell C, Mosca F, Boggi U, Sutton R, Slavin J, Hartley M, Neoptolemos JP.  Standard Kausch-Whipple pancreatoduodenectomy. Digestive Surgery 1999; 16: 297-304.

Pedrazzoli S, Beger H, Obertop H, Andrén-Sandberg Åke Fernandez-Cruz L, Henne-Bruns D, Lütges J, Neoptolemos JP.  A Surgical and pathological based classification of resection of pancreatic cancer: summary of an international workshop on surgical procedures in pancreatic cancer.  Digestive Surgery 1999; 16: 337-345.

Neoptolemos JP, Baker P, Johnson CD, Cunningham D, Spooner D, for the UK Pancreatic Cancer Group.  Adjuvant radiotherapy and follow-on chemotherapy in patients with pancreatic cancer.  Results of the UK Pancreatic Cancer Group study (UKPACA-1). GI Cancer 1998; 2: 235-245.

McCarthy MJ, Evans J, Sagar G, Neoptolemos JP.  Prediction of resectability for pancreatic malignancy by computed tomography.  British Journal of Surgery 1998; 85: 320-325.

British Society of Gastroenterology Working Party (includes Neoptolemos JP). United Kingdom Guidelines For The Management of Acute Pancreatitis Gut 1998; 42 (Suppl 2): SI-S13.

Singh S, Baker PR, Poulsom R, Wright NA, Sheppard MC, Langman MJS, Neoptolemos JP. Expression of oestrogen receptor  and oestrogen-inducible genes in pancreatic cancer. British Journal of Surgery 1997; 84: 1085-1089.

Stonelake PS, Jones CE, Neoptolemos JP, Baker P.  Proteinase inhibitors reduce basement degradation by human breast cancer cell lines.  British Journal of Cancer 1997; 75: 951-959.

Williams JG, Bramhall SR, Neoptolemos JP.  Purse-string pancreatico-jejunostomy following pancreatic resection.  Digestive Surgery 1997; 14: 183-186.

Evans JD, Wilson P, Carver C, Bramhall SR, Buckels JAC, Mayer AD, McMaster P, Neoptolemos JP.  Outcome of surgery for chronic pancreatitis.  British Journal of Surgery 1997; 84: 624-629.

Neoptolemos JP, Baker P, Beger H, Link K, Pederzolli P, Bassi C, Dervenis C, Friess H, Büchler M. Progress Report: A randomised multicentre European study comparing adjuvant radiotherapy, six months’ chemotherapy and combination therapy versus no adjuvant treatment in resectable pancreatic cancer (ESPAC-1). International Journal of Pancreatology 1997; 21: 97-104.

Hamanaka Y, Evans J, Sagar G, Neoptolemos JP.  Complete pancreatic encasement of the proximal hepatic portal vein: a previously undescribed anomoly. British Journal of Surgery 1997; 84: 785.

Bramhall S, Neoptolemos JP, Stamp G, Lemoine N.  Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in human pancreatic cancer.  Journal of Pathology 1997; 182: 347-355.

Green NK, Youngs DJ, Neoptolemos JP, Friedlos F, Knof RJ, Springer CJ, Anzelark GM, Michael NP, Melton RG, Young LS, Kerr DJ, Searle PF.  Sensitization of colorectal and pancreatic cancer lines to the prodrug 5-aziridin-1-yl-2, 4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E Coli nitroreductase gene.  Cancer Gene Therapy 1997; 4: 229-238.

Neoptolemos JP, Russell RCG, Bramhall S, Theis B for the UK Pancreatic Cancer Group.  Low mortality following resection for pancreatic and periampullary tumours in 1026 patients:  UK survey of pancreatic specialist units. British Journal of Surgery 1997; 84: 1370-1376.

Evans JD, Eggo MC, Donovan IA, Bramhall SR, Neoptolemos JP. Serum levels of insulin-like growth factors (IGF-I and IGF-II) and their binding protein (IGFBP-3) are not elevated in pancreatic cancer. International Journal of Pancreatology 1997; 22: 95-100.

Neoptolemos JP, Kerr DJ, Beger HG, Link K, Pederzolli P, Bassi C, Dervenis C, Fernandez-Cruz L, Laçaine F, Friess H, Büchler M. ESPAC-1 Trial Progress Report: The European randomised adjuvant study comparing radiochemotherapy, six months chemotherapy and combination therapy versus observation in resected pancreatic cancer.  Digestion, 1997; 58: 570-577.

Bramhall SR, Stamp GWH, Dunn J, Lemoine NR, Neoptolemos JP.  Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.  British Journal of Cancer 1996; 73:982-988.

Evans, J, Neoptolemos JP.  Duodenal gangliocytic paraganglioma presenting as an ampullary tumour.  International Journal of Pancreatology 1996, 20: 131-134.

Seymour MT, Slevin ML, Kerr DJ, Cunningham D,  James RD, Lederman JA, Perren TJ, McAdam WAF, Harper PG, Neoptolemos JP, Duffy MA, Stephens RJ, Stenning SP, Taylor I.  A randomized trial of assessing the addition of interferon a2a to 5-fluorouracil and leucovorin in advanced colorectal cancer.  Journal of Clinical Oncology 1996, 14: 2280-2288.

Kerr DJ, Young AM, Neoptolemos JP, Sherman M, Van-Geere P, Stanley A, Ferry D, Dobbie JW, Vincke B, Gilbert J, El Eini D, Nombros N, Foutzilas G. Prolonged intraperitoneal infusion of 5-fluorouracil using a novel carrier solution. British Journal of Cancer 1996; 74: 2032-2035.

Crundwell M, Chughtai S, Knowles M, Takle L, Luscombe M, Neoptolemos JP,  Morton D, Phillips S.  Allelic loss on chromosomes 8p, 22q and 18q (DCC) in human prostate cancer.  International Journal of Cancer 1996; 22: 295-30.

Stonelake PS, Powell J, Dunn JA, Warwick J, Bramhall SR, Neoptolemos JP, Baker PR, Morrison JM.  Influence of timing of surgery during menstrual cycle on survival of premenopausal women with operable breast cancer.  Breast 1995; 4:19-24.

Radley S, Imray CHE, Setchell  KDR, O’Connell N, Donovan IA, Neoptolemos JP.  Faecal neutral steroid concentrations are increased in patients with colorectal cancer.  GI Cancer 1995; 1:61-64.

Hendrickse CW, Radley S, Donovan IA, Keighley MRB, Neoptolemos JP.  Tumour phospholipse A2 and diacylglycerol lipase activities are increased in colorectal cancer.  British Journal of Surgery 1995; 82:475-478.

Neoptolemos JP, Oates GD, Newbold KM, Robson AM, Maconkey C, Powell J.  Cyclin/PCNA immuno-histochemistry does not improve the prognosis of the Dukes' or Jass' staging systems for colorectal cancer.  British Journal of Surgery 1995; 82:184-187.

Bain IM, Mostafa AB, Harding LK, Neoptolemos JP, Keighley MRB.  Bile acid absorption from ileoanal pouches using enema 75SeHCAT scintigraphy.  British Journal of Surgery 1995; 82:614-617.

Bramhall S, Allum W, Cummings C, Jones A, Altwood A, Neoptolemos JP.  Incidence, treatment and outcome in 13,600 cases of pancreatic cancer: An epidemiological study in the West Midlands, UK.   British Journal of Surgery 1995; 82:111-115.

Pongracz JA, Neoptolemos JP, Lord JM.  Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids.  International Journal of Cancer 1995; 61:35-39.

Hendrickse C, Keighley MRB, Neoptolemos JP.  Dietary omega-3 fats reduce colonic anastomotic tumours in the rat.  Gastroenterology 1995; 109: 431-439.

Gray I, Phillips SMA, Lee SJ, Neoptolemos JP, Weissembach J, Spurr NK.  Loss of chromosomal region 10q23-q25 in prostate cancer.  Cancer Research 1995; 55:4800-4803.

Kerr DJ, Lederman JA, McArdle CS, Buckels J, Neoptolemos JP, Seymour M, Doughty J, Budden J, Taylor I.  Phase I clinical and pharmacokinetic study of folinic acid and infusional hepatic arterial 5-fluorouracil.  Journal of Clinical Oncology 1995; 13: 2968-2972.

Phillips SM, Morton D, Lee SJ, Wallace DM, Cairns P, Neoptolemos JP.  Loss of heterozygosity of RB1 and APC loci and of loci in chromosomes 10p, 10q, and 16q in human prostatic cancer.  British Journal of Urology 1994; 73:390-395.

Kmiot WA, Perry EP, Lee MJR, Wolverson RL, Donovan IA, Harding LK, Neoptolemos JP.  Cholesterolosis in patients with chronic acalculous biliary pain.  British Journal of Surgery 1994; 81:112-115.

Barker G, Radley S, Davis A, Imray CHE, Setchell KDR, O'Connell N, Donovan IA, Keighley MRB, Neoptolemos JP.  Unconjugated faecal bile acid analysis in familial adenomatous polyposis analysed by gas chromatography-mass spectrometry.  British Journal of Surgery 1994; 81:739-742.

Stonelake PS, Gillespie WM, Baker PG, Dunn JA, Morrison JM, Lee MJR, Bundred NJ, Spooner DA, Neoptolemos JP, Baker PR.  Steroid receptors, pS2 and cathepsin D in early clinically node-negative breast cancer.  European Journal of Cancer 1994; 30A: 5-11.

Hendrickse C, Kelly R, Radley S, Donovan IA, Keighley MRB,  Neoptolemos JP.  Lipid peroxidation and prostaglandins in colorectal cancer.   British Journal of Surgery 1994 ; 81:1219-1223.

Barker GM, Radley S, Bains I, Davis A, Lawson AM, Keighley MRB,  Neoptolemos JP.  Biliary bile acid profiles in untreated patients with familial adenomatous polyposis and following colectomy.  British Journal of Surgery 1994; 81:441-444.

Moran A, Hendrickse C, Jones AF, Neoptolemos JP.  Enteric alpha-1-antitrypsin loss and comparison with Okokit II and haemoccult for the detection of colorectal cancer. Surgical Oncology 1994; 3:147-151

Phillips S, Barton C, Lee SJ, Morton DG, Wallace DM, Lemoine N, Neoptolemos JP.  Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumourigenesis.  British Journal of Cancer 1994; 70:1252-1257.

Wallis Y, MacDonald F, McKeown C, Keighley M, Neoptolemos JP, Morton D.  Genotype-phenotype correlations between position of constitutional APC gene mutations and CHRPE expression in familial adenomatous polyposis.  Human Genetics 1994; 84:543-548.

Moran A, Radley S, Neoptolemos JP, Jones AF, Asquith P.   Detection of colorectal cancer by faecal alpha-1-antitrypsin. Annals of Clinical Biochemistry 1993; 30:28-33.

Neoptolemos JP, London NJM, Carr-Locke DL.  Assessment of main pancreatic duct integrity by endoscopic retrograde pancreatography in patients with acute pancreatitis.  British Journal of Surgery 1993; 80:94-99.

Morton D, Haydon J, Cudlen R, Gibson J, MacDonald F, Hulten M, Neoptolemos JP, Keighley MRB, McKeown C.  Screening practice for familial adenomatous polyposis: the potential for regional registers.  British Journal of Surgery 1993; 80:255-258.

Hendrickse CW, Jones C, Donovan IA, Neoptolemos JP, Baker PR.  Oestrogen and progesterone receptors in colorectal cancer.  British Journal of Surgery 1993; 80:636-640.

Radley S, Imray CHE, Davis A, Hendrickse C, Lawson A, Baker PR, Neoptolemos JP.  Duodenal gallbladder bile acid profiles in patients with colorectal cancer or with polyps.  European Journal of Hepatology and Gastroenterology 1993; 5:721-729.

Bradley E and Members of the Atlanta International Symposium.  A clinically based classification system for acute pancreatitis.  Archives of Surgery 1993; 128:586-590.

Kmiot WA, Neoptolemos JP, Temple JG.  Research in higher surgical training - the West Midlands' view.  Annals of the Royal College of Surgeons of England 1993; 75 (Suppl):147-149.

Kmiot WA, Stonelake P, Sagar G, Donovan IA, Neoptolemos JP, Harding LK.  Radioimmunoscintigraphy of recurrent colorectal carcinoma using 111Indium labelled murine monoclonal antibody B72.3 - a comparison with contrast enhanced CT scanning.  Journal of Nuclear Medicine Communications 1993; 14:788-791. 

Barker G, Radley S, Davis A, Setchell KDR, O'Connell N, Donovan IA, Keighley MRB, Neoptolemos JP. Analysis of faecal neutral sterols in patients with familial adenomatous polyposis by gas chromatography-mass spectrometry.  International Journal of Colorectal Disease 1993; 8:188-192.

MacDonald F, Morton D, McKeown C, Neoptolemos JP, Keighley MRB, Hulten M.  Predictive diagnosis of familial adenomatous polyposis by molecular markers in a defined population.  British Medical Journal 1992; 304: 869-872.

Imray CHE, Newbold KM, Davis A, Lavelle-Jones M, Neoptolemos JP.  Cholangiocarcinoma in the Golden Syrian hamster using methylazoxymethanol acetate.  European Journal of Surgical Oncology 1992; 18:373-378.

Nicholson M, Neoptolemos JP, Clayton HR, Talbot IC, Bell PRF.  Relation of dietary fat to tissue fatty acids in experimental colorectal carcinogenesis.  European Journal of Surgical Oncology 1992; 18:146-151,

Winslet MC, Hall C, London NJM, Neoptolemos JP.  Relationship of diagnostic serum amylase to aetiology and prognosis in acute pancreatitis.  Gut 1992; 33:982-986.

Barsoum GHB, Winslet MC, Youngs D, Neoptolemos JP, Keighley MRB.  Influence of dietary calcium supplementation on ileoanal pouch function and cytokinetics.  British Journal of Surgery 1992; 79: 129-132.

Barsoum GHB, Hendrickse C, Winslet MC, Youngs D, Donovan IA,  Neoptolemos JP, Keighley MRB.  Reduction of mucosal crypt cell proliferation in patients with colorectal adenomatous polyps by dietary calcium supplementation.   British Journal of Surgery 1992; 79:581-583.

Morton D, Haydon J, Cudlen R, Gibson J, Barker G, Hulten M, McKeown C, MacDonald F, Neoptolemos JP, Keighley MRB.  The role of CHRPEs in the diagnosis of familial adenomatous polyposis.  British Journal of Surgery 1992; 79:689-693.

Imray CHE, Minoura T, Davis A, Radley S, Lawson A, Lavelle-Jones M, Baker PR, Neoptolemos JP.  Comparative faecal bile acids of hamsters and humans in experimental colonic cancer by intra-rectal instillation of N-methyl-N-nitro-N-nitrosoguanidine.  Anticancer Research 1992; 12:553-558.

Imray CHE, Radley S, Davis A, Hendrickse C, Lawson A, Donovan IAD, Baker PR, Neoptolemos JP.  Faecal unconjugated bile acids in patients with colorectal cancer or polyps.  Gut 1992; 33:1239-1245.

Morton DG, MacDonald F, Rindl M, Neoptolemos JP, Keighley MRB, McKeown C, Kilpatrick M, Hulten M.  The use of DNA from paraffin wax preserved tissue for predictive diagnosis in familial adenomatous polyposis.  Journal of Medical Genetics 1992; 29:571-573.

Barsoum GHB, Thompson H, Neoptolemos JP, Keighley MRB.  Dietary calcium does not reduce experimental colorectal carcinogenesis following small bowel resection despite reducing cellular proliferation.  Gut 1992; 33:1515-1520.

De-Netto LA, Tappia PS, Malik ZA, Wood AJ, Maria VM, Jones CJ, Burdett K, Neoptolemos JP, Connock MJ.  Human hepatic peroxisomes with crystalloid cores associated with urate oxidase activity.  Advances in Experimental Medicine and Biology 1991; 390A: 373-376.

Davis AE, Imray CHE, Minoura T, Winslet M, Baker PR, Neoptolemos JP.   Gas liquid chromatography (GLC) analysis of hamster biliary conjugated bile acids.   Biochemical Society Transactions 1991;  19: 171S

Imray CHE, Davis A, Barker G, Radley S, Baker PR, Neoptolemos JP.  Improved human faecal bile acid extraction. Biochemical Society Transactions 1991; 19:201S.

Imray C., Billingham M, Miles J, Wright A, Filer R, Bradwell J, Neoptolemos JP.  Changes in serum lipids after exercise and on exposure to altitude.  Biochemical Society Transactions 1991; 19:135S.

Winslet M, Hall C, Hendrickse C, Lawson N, Neoptolemos JP.  Serum phospholipase A2 and free fatty acid levels in acute pancreatitis.  Biochemical Society Transactions 1991; 19:225S.

Leese T, Hall C, Holliday M, Watkins M, Neoptolemos JP, Thomas M, Attard A.  Multicentre prospective randomised trial of high volume fresh frozen plasma therapy in severe pancreatitis. Annals Royal College of Surgeons of England 1991; 73: 207-214.

Hall C, Dorricott N, Donovan IAD.  Neoptolemos JP. Colonoscopic perforation: Surgical versus conservative management. British Journal of Surgery 1991; 78: 542-544.

Neoptolemos JP, Carr-Locke DL, Kelly KA.  Factors affecting the diameters of the common bile duct and pancreatic duct using endoscopic retrograde cholangiopancreatography. Hepatogastroenterology 1991; 38; 243-247.

Nicholson ML, Neoptolemos JP, Clayton HA, Talbot IC, Bell PRF. Increased arachidonic acid in cell membranes of experimental colorectal tumours. Gut 1991; 32: 413-418.

Neoptolemos JP, Husband N, Rowley S, Imray C, Lawson N. Increased arachidonic acid and docosahexaenoic acid in human colorectal cancer.  Gut  1991; 32: 278-281.

Rowley S, Carpenter R, Newbold M, Gearty J, Keighley MRB, Donovan IA, Neoptolemos JP.  p62 c-myc  and prognosis in colorectal cancer.  European Journal of Surgical Oncology 1991; 17: 370-378.

Wood A.J., Malik ZA, Tappia PS, Poxon V, Grace R, Neoptolemos JP, Burdett K, Connock MJ.  Isolation of microperoxisomes from human colonic mucosa.  Biochemical Society Transactions 1991; 19: 425S.

Barton CM, Staddon SL, Hughes CM, Hall PA, 0'Sullivan C, Kloppel G, Theis B, Russell C, Neoptolemos JP, Williamson RCN, Lane DA, Lemoine NR.  Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer.  British Journal of Cancer 1991; 64: 1076-1082.

Neoptolemos JP, Thomas BS.  Erythrocyte membrane stearic: oleic acid ratios in colorectal cancer using tube capillary column gas chromatography.  Annals of Clinical Biochemistry 1990; 29: 38-43.

Neoptolemos JP, Hall C, 0'Connor HJ, Murray WR, Carr-Locke DL.  How good is methyl tert butyl ether for treating bile duct stones?  The British experience.  British Journal of Surgery 1990; 77: 32-35.

Winslet M, Neoptolemos JP.  Colonic volvulus and gastrointestinal atony: a fatal manifestation of progressive systemic sclerosis. Coloproctology 1990; 382-385.

Jewkes A, Allum WH, Downing R, Fielding JWL, Drolc Z, Neoptolemos JP.  Radioimmunolocalisation using the radiolabelled monoclonal anti-CEA antibody II-285-14 lacks diagnostic utility for the differentiation of pancreatic and bile duct cancer from chronic pancreatitis and sclerosing cholangitis.  International Journal of Pancreatology 1990; 7: 261-277.

Winslet MC, Bramhall S, Neoptolemos JP, Harding LK, Hesslewood SK.  A diffuse increase in renal uptake of Tc99m methylene diphosphonate in association with disseminated cholangiocarcinoma. European Journal of Nuclear Medicine 1990;  17: 372-373.

Hall C, Wingate J, Hall P, Neoptolemos JP.  Evaluation of herniography in the diagnosis of occult abdominal wall hernia in symptomatic adults.  British Journal of Surgery 1990; 77: 922-926.

Rowley S, Donovan IA, Newbold KM, Gearty J, Keighley MRB, Neoptolemos JP. Comparison of deoxyribonucleic acid ploidy and nuclear expressed p62 c-myc oncogene in the prognosis of colorectal cancer.  World Journal of Surgery 1990; 14: 545-551.

Sakaguchi M, Rowley S, Kane N, Imray C, Davis A, Jones C, Newbold M, Keighley M, Baker PR, Neoptolemos JP.  Reduced tumour growth of the human colonic cancer cell lines colo-320 and HT-29 in vivo by dietary N-3 lipids.  British Journal of Cancer 1990; 62: 742-747.

Nicholson M, Neoptolemos JP, Clayton HR, Talbot IC,  Bell RF.   Inhibition of experimental colorectal carcinogenesis by dietary N-6 polyunsaturated fatty acids.  Carcinogenesis 1990 11: 2191-2197.

Sakaguchi M, Imray C, Davis A, Rowley S, Jones C, Lawson N, Keighley M, Baker PR, Neoptolemos JP.  Effects of dietary N-3 and saturated fats on growth rates of human colonic cancer cell lines SW-620 and LS174T in vitro  in relation to tissue and plasma lipids. Anticancer Research 1990; 10: 1763-1768.

Scott AJH, Neoptolemos JP, Windle RW.  Adenocarcinoma cell invasion of an obturator artery aneurysm. European Journal of Surgical Oncology 1989; 15: 8384.

Neoptolemos JP, Shaw DE, Carr-Locke DL.  A multivariate analysis of preoperative risk factors in patients with common bile duct stones - implications for treatment.  Annals of Surgery 1989; 209: 157-161.

London NJM, Neoptolemos JP, Lavelle J, James D. Serial CT scanning in acute pancreatitis.  Gut 1989; 30: 397-403.

London NJM, Neoptolemos JP, Lavelle J, Bailey I, James D. Contrast-enhanced abdominal CT scanning and prediction of severity of acute pancreatitis: a prospective study. British Journal of Surgery 1989; 76: 268-272.

Nicholson ML, Neoptolemos JP, Sharp JF, Watkin EM, Fossard DP.  Localisation of lower gastrointestinal bleeding using in vivo 99m technetium labelled red blood cell scintigraphy. British Journal of Surgery 1989; 76: 358-361.

Neoptolemos JP.  The theory of 'persisting' common bile duct stones in severe gallstone pancreatitis.  Annals Royal College of Surgeons of England 1989; 71: 326-33.

Talbot IC, Neoptolemos JP, Shaw DE, Carr-Locke DL.  The histopathology and staging of carcinoma of the ampulla of Vater. Histopathology 1988; 12:155-165.

Davidson BR, Neoptolemos JP, Carr-Locke DL.  Endoscopic sphincterotomy for common bile duct calculi in patients with gallbladder in situ considered unfit for surgery.  Gut 1988; 29:114-120.

Neoptolemos JP, Bailey I, Carr-Locke DL.  Sphincter of Oddi dysfunction: results of treatment by endoscopic sphincterotomy. British Journal of Surgery 1988; 75:450-453.

Ubhi SS, Neoptolemos JP, Watkin DFL. Incidence of diagnosis of parotid gland tuberculosis in Asians in Leicester.  British Journal of Surgery 1988; 75:313.

Davidson BR, Neoptolemos JP, Leese T, Carr-Locke DL.  Biochemical prediction of gallstones in acute pancreatitis: a prospective study of three systems.  British Journal of Surgery 1988; 75:213-215.

Neoptolemos JP, Davidson BR, Vallence D, Winder AF.  The role of bile crystal analysis in the detection of gallstones in patients with "idiopathic" pancreatitis.  British Journal of Surgery 1988; 75:454-459.

Neoptolemos JP, Talbot IC, Shaw DE, Carr-Locke DL.  Long term survival following resection of ampullary carcinomas is independently associated with tumour grade and a new staging classification which assesses local invasiveness.  Cancer 1988; 61:1403-1407.                  

Davidson BR, Neoptolemos JP, Watkin D, Talbot IC.  Invasive amoebiasis: an unusual presentation.  Gut 1988; 29: 682-5.      

Neoptolemos JP, Clayton HC, Heagerty AM, Nicholson MJ, Johnson B, Mason J, Manson K, James RF, Bell PRF.  Dietary fat in relation to fatty acid composition of red cells and adipose tissue in colorectal cancer. British Journal of Cancer 1988; 58: 575-579.

Neoptolemos JP, Carr-Locke DL, London NJM, Fossard DP. ERCP findings and the role of endoscopic sphincterotomy in acute gallstones pancreatitis.  British Journal of Surgery 1988; 75: 954-60.

Neoptolemos JP, Carr-Locke DL, London NJM, Bailey I, James D, Fossard DP.  Results of a prospective randomized trial of ERCP and endoscopic sphincterotomy in acute gallstone pancreatitis. Lancet 1988; ii: 979-983.

Baker AR, Neoptolemos JP, Leese T, Fossard DP. Choledochoduodenostomy and transduodenal sphincteroplasty and sphincterotomy for calculi of the common bile duct.  Surgery, Gynecology, Obstetrics 1987; 164:245-251.

O'Doherty D, Neoptolemos JP, Bouch C, Wood KF.  Surgical complications of amyloid disease.  Postgraduate Medical Journal 1987; 63:281-286.

Davidson BR, Brown N, Neoptolemos JP.  Haemorrhage into a urachal cyst presenting as an acute abdomen.  Postgraduate Medical Journal 1987; 63:493-4.

Baker AR, Neoptolemos JP, Leese T, James DC, Fossard DP.  Long-term follow-up of patients with side-to-side choledochoduodenostomy and transduodenal sphincteroplasty:  A clinical biochemical and radiological study.  Annals of the Royal College of Surgeons of England 1987; 68:253-257.

Neoptolemos JP, Carr-Locke DL, Fossard DP.  Results of a prospective randomised study of pre-operative endoscopic sphincterotomy versus surgery alone for common bile duct stones. British Medical Journal 1987; 294:470-474.

Neoptolemos JP, Davidson BR, Vallence D, Winder AF.  Bile-crystal analysis for the detection and type-identification of gallstones.  Biochemical Society Transactions 1987; 15:1912-13.

Neoptolemos JP, Talbot IC, Carr-Locke DL, Shaw DE, Cockleburgh R, Hall AW, Fossard DP.  Treatment and outcome in 52 consecutive cases of ampullary carcinoma.    British Journal of Surgery 1987; 74:957-961.

Neoptolemos JP, Davidson BR, Shaw DE, Lloyd D, Carr-Locke DL, Fossard DP.  A study of common bile duct exploration and endoscopic sphincterotomy in a consecutive series of 438 patients.  British Journal of Surgery 1987; 74:916-7.

Neoptolemos JP, Carr-Locke DL, Leese T, James D.  Acute cholangitis in association with acute pancreatitis: incidence, clinical features and outcome in relation to ERCP and endoscopic sphincterotomy. British Journal of Surgery 1987; 74:1103-1106.

Neoptolemos JP, Wood P, Everson NW, Bell PRF.  The effect of surgical procedures on monocyte function in patients with carcinoma of the colon and rectum.    Surgery, Gynecology and Obstetrics 1986; 163:235-242.                    

Neoptolemos JP, London N, Slater N, Carr-Locke DL, Fossard DP, Moossa AR.  A prospective study of ERCP and endoscopic sphincterotomy  in the diagnosis and treatment of gallstone acute pancreatitis.  Archives of Surgery 1986; 121:697-702.

London N, Lloyd D, Pearson H, Neoptolemos JP, Bell PRF.  Acute pancreatitis complicating parathyroid surgery.  British Journal of Surgery 1986; 73:766-767.

Van Sonnenberg E, Hofmann AF, Neoptolemos JP, Wittich GR, Princenthal RA, Wilson S.  Gallstone dissolution with methyl-tert-butyl ether via percutaneous cholecystostomy:  Success and caveats.  American Journal of Roentgenology 1986; 146:865-867.

O'Doherty D, Neoptolemos JP, Carr-Locke DL.  Endoscopic sphincterotomy for retained common bile duct stones in patients with T-tube in situ in the early post-operative period.  British Journal of Surgery 1986; 73:454-456.

Neoptolemos JP, London N, Bailey I, Shaw D, Carr-Locke DL, Fossard DP, Moossa AR.  The role of clinical and biochemical criteria and endoscopic retrograde cholangiopancreatography in the urgent diagnosis of common bile duct stones in acute pancreatitis. Surgery 1986; 100:732-743.

Leese T, Neoptolemos JP, West KP, Talbot IC, Carr-Locke DL.  Tumours and pseudotumours of the region of the ampulla of Vater: An endoscopic, clinical and pathological study.  Gut 1986; 27:1186-1192.   

Leese T, Neoptolemos JP, Baker AR, Carr-Locke DL. The management of acute cholangitis and the impact of endoscopic sphincterotomy for calculi of the common bile duct.    British Journal of Surgery 1986; 73:988-992.

Goodman AJ, Neoptolemos JP, Findlay D, Carr-Locke DL, Fossard DP.  Detection of gallstones following acute pancreatitis.  Gut 1985; 26:125-132.

Harvey MH, Neoptolemos JP, Cosgriff P, Watkin EM, Barry WW.  Technetium labelled red blood cell scintigraphy in the diagnosis of intestinal haemorrhage.  Annals of the Royal College of Surgeons of England 1985; 67:89-92.

Leese T, Neoptolemos JP, Carr-Locke DL.  Successes, failures, early complications and their management following endoscopic sphincterotomy.  Results in 394 consecutive patients from a single centre.  British Journal of Surgery 1985; 72:215-219.

Neoptolemos JP, Wood P, Everson NW, Bell PRF.  Monocyte function following surgery in man. European Surgical Research 1985; 17:215-220.

Miller ES, Neoptolemos JP, Aitkenhead A, Fossard DP.  Management of severe head injuries in a non-neurosurgical trauma centre. Journal of the Royal College of Surgeons of Edinburgh 1985; 30:82-87.

Baker AR, Neoptolemos JP, Carr-Locke DL, Fossard DP.  Sump syndrome following choledochoduodenostomy and its endoscopic treatment.  British Journal of Surgery 1985; 72:433-435.

Baker AR, Neoptolemos JP, Wood KF.  Congenital anterior urethral diverticulum: A rare cause of lower urinary tract obstruction in childhood.  Journal of Urology 1985; 134:751-752.

Neoptolemos JP, Fraser I, Carr-Locke DL, Fossard DP.  The management of common bile duct calculi by endoscopic sphincterotomy in patients with gall bladders in situ.  British Journal of Surgery 1984; 71:69-71.

Neoptolemos JP, Hall AW, Findlay D, Berry JM, Carr-Locke DL, Fossard DP.  The urgent diagnosis of gallstones in acute pancreatitis:  A prospective study of three methods.    British Journal of Surgery 1984; 71:230-233.

Fraser I, Neoptolemos JP, Darby H, Bell PRF.  The effects of intralipid and heparin on human monocyte and lymphocyte function.  Journal of Parenteral and Enteral Nutrition 1984; 8:381-384.

Harvey MH, Neoptolemos JP, Fossard DP.  Polyarteritis Nodosa:  A possible surgical pitfall. British Journal of Clinical Practice 1984; 38:282-283.

Neoptolemos JP, Harvey MH, Slater ND, Carr-Locke DL. Abdominal bile wall staining and "biliscrotum" from retroperitoneal bile leakage following endoscopic sphincterotomy.  British Journal of Surgery 1984; 71:684.

Neoptolemos JP, Locke TJ.  Recurrent small bowel obstruction associated with phenylbutazone.  British Journal of Surgery 1983, 70:244-245.

Neoptolemos JP, Berry JM, Fossard DP.  A prospective study of radionuclide biliary scanning in acute pancreatitis. Annals of the Royal College of Surgeons of England 1983, 65:180-182.

Fraser I, Neoptolemos JP, Woods P, Bowry V, Bell PRF.  The effect of intralipid on human lymphocyte and monocyte function. Clinical Nutrition 1983; 2:37-40.

Neoptolemos JP, Darby H, Bolton E, Bell PRF.  Monocyte chemotaxis:  A simple measuring technique. Medical Laboratory Sciences 1983; 40:291-294.

Windle R, Findlay D, Neoptolemos JP.  Needle aspiration in the treatment of pancreatic pseudocysts in childhood. Annals of the Royal College of Surgeons of England 1983; 65:331.

Neoptolemos JP, Macpherson DS, Lundgren F, Fossard DP. Pyogenic liver abscess: A study of 44 cases in two centres.  Acta Chirurgica Scandinavica 1982; 148:415-421.

Everson NW, Neoptolemos JP, Scott JDA, Wood RFM, Bell PRF. Monocyte function following surgery.  British Journal of Surgery 1981; 68:257-260.

Greenhalf W, Grocock C, Harcus M, Neoptolemos J. Screening of High-Risk Families for Pancreatic Cancer. Pancreatology. 2009; 9(3): 215-222.

Bruns H, Rahbari NN, Löffler T, Diener MK, Seiler CM, Glanemann M, Butturini G, Schuhmacher C, Rossion I, Büchler MW, Junghans T; DISPACT Trial group. Perioperative management in distal pancreatectomy: results of a survey in 23 European participating centres of the DISPACT trial and a review of literature. Trial 2009 Jul 26;10:58.

Ghaneh P, Smith R, Tudor-Smith C, Raraty M, Neoptolemos JP. Neoadjuvant and adjuvant strategies for pancreatic cancer. Eur J Surg Oncol. 2008; 34(3):297-305.

Alexakis N, Neoptolemos JP.  Pancreatic neuroendocrine tumours. Best Pract Res Clin Gastroenterol. 2008;22(1):183-205.

Middleton G, Ghaneh P, Costello E, Greenahlf W, Neoptoelmos JP.  New treatment options for advanced pancreatic cancer.  Expert Rev Gastroenterol Hepatol. 2008; 2(5):673-696.

Greenhalf W, Malats N, Nilsson M, Bartsch D, Neoptolemos J. International Registries of Families at High Risk of Pancreatic Cancer. Pancreatology. 2008;8(6):558-565.

Ghaneh P, Costello E, Neoptolemos JP. Biology and management of pancreatic cancer.  Postgrad Med J. 2008; 84(995):478-97.

Sultana A, Neoptolemos J, Ghaneh P. Pancreatic cancer – adjuvant therapy.  Chinese-German Journal of Clinical Oncology 2007; 6: 170 - 175.

Ghaneh P, Costello E, Neoptolemos JP.  Biology and management of pancreatic cancer.  Gut 2007; 56:1134-52;  Postgrad Med J. 2008 Sep;84(995):478-97.

Ghaneh P, Neoptolemos JP.  Adjuvant Chemotherapy – the standard after resection for Pancreatic Cancer. American Journal of Surgery 2007; 194:S131-137.

Alexakis N, Lombard M, Raraty M, Ghaneh P, Smart HL, Gilmore I, Evans J, Hughes M, Garvey C, Sutton R, Neoptolemos JP. When is pancreatitis considered to be of biliary origin and what are the implications for management? Pancreatology 2007; 7(2-3):131-41.

Aung KL, Smith DB, Neoptolemos JP. Adjuvant therapy for pancreatic cancer. Expert Opin Pharmacother. 2007; 8(15):2533-41.

Grocock CJ, Vitone LJ, Harcus MJ, Neoptolemos JP, Raraty MG, Greenhalf W. Familial pancreatic cancer: a review and latest advances. Adv Med Sci. 2007; 52:37-49.

Smith DB, Neoptolemos JP.  Capecitabine in carcinoma of the pancreas.  Expert Opinions in Pharmacotherapy 2006; 7(12):1633-9.

Connor S, Raraty MG, Neoptolemos JP, Layer P, runzi M, Steinberg WM, Barkin JS, Bradley EL 3rd, Dimagno E.  Does infected pancreatic necrosis require immediate or emergency debridement?  Pancreas 2006; 33(2):128-34.

Vitone LJ, Greenhalf W, Howes NR, Raraty MG, Neoptolemos JP.  Trypsinogen mutations in pancreatic disorders.  Endocrinology Metabolic Clinics North America 2006; 35(2):271-87, viii.

Ghaneh P, Sultana A, Shore S, Stocken D, Neoptolemos J.  The case for adjuvant chemotherapy in pancreatic cancer.  Best Practic Research Clinical Gastroenterology 2006; 20(2):383-401.

Vitone LJ, Greenhalf W, McFaul CD, Ghaneh P, Neoptolemos JP.  The inherited genetics of pancreatic cancer and prospects for secondary screening.  Best Practic Research Clinical Gastroenterology 2006; 20(2):253-83.

Starling N, Neoptolemos J, Cunningham D. Role of erlotinib in the management of pancreatic cancer. Therapeutics and Clinical Risk Management. 2006; 2 (4): 435-445.

Sultana A, Neoptolemos J, Ghaneh P. Pancreas cancer: Adjuvant treatment. HPB (Oxford). 2006; 8 (5):352-64

Howes N, Greenhalf W, Stocken DD, Neoptolemos JP. Cationic trypsinogen mutations and pancreatitis. Clin Lab Med 2005; 25(1):39-59.

Alexakis N, Neoptolemos JP.  Algorithm for the diagnosis and treatment of acute biliary pancreatitis.  Scandinavian Journal of Surgery 2005; 94:124-129

Connor S, Raraty MGT, Howes N, Evans J, Ghaneh P, Sutton R, Neoptolemos JP.  Surgery in the treatment of acute pancreatitits - minimal access pancreatic necrosectomy.  Scandinavian Journal of Surgery 2005; 94:135-142

Halloran CM, Ghaneh P, Costello E, Neoptolemos JP.  Trials of gene therapy for pancreatic carcinoma.  Current Gastroetnerology Reports 2005; 7(3):165-169.

Wolfson D, Barkin JS, Chari S, Clain JE, Bell RH, Alexakis N, Neoptolemos JP.  Management of pancreatic masses.  Pancreas 2005; 31(3):203-217.

Vitone LJ, Greenhalf W, Howes NR, Neoptolemos JP.  Hereditary pancreatitis and secondary screening for early pancreaitc cancer.  Rocz Akad Med Bialymst 2005; 50:73-84.

Raraty MG, Connor S, Criddle DN, Sutton R, Neoptolemos JP. Acute pancreatitis and organ failure: pathophysiology, natural history, management strategies. Current Gastroenterology Reports 2004; 6(2):99-103. 

Vimalachandran D, Ghaneh P, Costello E, Neoptolemos JP. Genetics and prevention of pancreatic cancer. Cancer Control. 2004; 11(1):6-14.

Howes N, Greenhalf W, Stocken D, Neoptolemos JP. PRSS1 mutations and chronic pancreatitis. Gastroenterology Clinics of North America 2004; 33(4):767-87.

Alexakis N, Sutton R, Neoptolemos JP.  Surgical treatment of pancreatic fistula.  Digestive Surgery 2004; 21:262-274.

Alexakis N, Connor S, Ghaneh P, Lombard M, Smart HL, Evans J, Hughes M, Garvey CJ, Vora J, Vinjamuri S, Sutton R, Neoptolemos JP.  Hereditary pancreatic endocrine tumours.  Pancreatology 2004; 4(5):417-435.

Ghaneh P, Neoptolemos JP. Conclusions from the European Study Group for Pancreatic Cancer adjuvant trial of chemoradiotherapy and chemotherapy for pancreatic cancer. Surgical Oncology Clinics of North America 2004; 13 (4):567-87.

Alexakis N, Halloran C, Raraty M, Ghaneh P, Sutton R, Neoptolemos JP. Current standards of surgery for pancreatic cancer. British Journal of Surgery 2004; 91:1410-27.

Neoptolemos JP, Raraty MG, Ghaneh P, Hickey H, Stocken DD, Dunn JA, Friess H, Buchler MW. Adjuvant and additive therapy for cancer of the pancreas. [Article in German].  Chirurg 2003;74:191-201.

Neoptolemos JP, Cunningham D, Friess H, Bassi C, Stocken DD, Tait DM, Dunn JA, Dervenis C, Lacaine F, Hickey H, Raraty MG, Ghaneh P, Buchler MW.Adjuvant therapy in pancreatic cancer: historical and current perspectives. Annals of Oncology 2003; 14(5): 675-692.

Rosso E, Alexakis N, Ghaneh P, Lombard M, Smart HL, Evans J, Neoptolemos JP. Pancreatic pseudocysts in chronic pancreatitis: endoscopic and surgical treatment. Digestive Surgery, 2003; 20(5):397-406.

Shore S, Raraty MG, Ghaneh P, Neoptolemos JP. Chemotherapy for pancreatic cancer. Aliment Pharmacol Ther 2003; 18(11-12):1049-69.

Sutton S, Doran H, Williams E, Vora J, Vinjamuri S, Evans J, Campbell F, Raraty M, Ghaneh P, Hartley M, Poston G, Neoptolemos J.  Surgery for midgut carcinoid. Endocrine-Related Cancer 2003;10(4): 469-81.

Sutton R, Criddle D, Raraty MGT, Tepikin AV, Neoptolemos JP, Petersen OH. Signal transduction, calcium and acute pancreatitis. Pancreatology, 2003; 3(6):497-505.

Neoptolemos JP, Ghaneh P, Hartley M, Sutton R, Magee CJ.  The role of adjuvant therapy for pancreatic cancer.  Expert Opin. Investig. Drugs 2002; 11: 87-107.

Ghaneh P, Kawesha A, Evans JD, Neoptolemos JP.  Molecular prognostic markers in pancreatic cancer.  Journal of Hepato-Biliary-Pancreatic Surgery 2002; 9: 1-11.

Halloran CM, Ghaneh P, Bosonnet L, Hartley MN, Sutton R, Neoptorlemos JP.  Complications of Pancreatic Cancer Resection.  Digestive Surgery 2002; 19: 138-146.

Magee CJ, Shekouh A, Ghaneh P, Neoptolemos JP.  Update on pancreatic cancer.  Hospital Medicine 2002; 63: 200-6.

Magee CJ, Ghaneh P, Neoptolemos JP.  Surgical and medical therapy for pancreatic carcinoma.  Clinical Gastroenterology 2002; 16: 435-55.

Andren-Sandberg, Neoptolemos JP.  Resection for pancreatic cancer in the new millennium.  Pancreatology 2002; 2: 431-439.

Raraty MG, Magee CJ, Ghaneh P, Neoptolemos JP.  New techniques and agents in the adjuvant therapy of pancreatic cancer.  Acta Oncol 2002; 41(7-8):583-595.

Bhatia M, Neoptolemos J P, Slavin J. Inflammatory mediators as therapeutic targets in acute pancreatitis. Current Opinions In Investigational Drugs 2001; 2: 496-501.

Slavin J, Neoptolemos JP.  Antibiotic porphylaxis in severe acute pancreatitis – what are the facts.  Langenbeck’s Archives of Surgery 2001; 386: 155-159.

Ghaneh P, Slavin JS, Sutton RS, Hartley M, Neoptolemos JP.  Adjuvant therapy in pancreatic cancer.  World J. Gastroenterology 2001; 7: 482-489.

Wong T, Howes N, Threadgold J, Smart HL, Lombard MG, Sutton R, Greenhalf W, Ellis I, Neoptolemos JP.  Molelcular Diagnosis of Early Pancreatic Ductal Adenocarcinoma in High Risk Patients.  Pancreatology 2001; 1: 486-509.

Halloran CM, Ghaneh P, Neoptolemos JP, Costello E. Gene therapy for pancreatic cancer-current and prospective stategies.  Surgical Oncology 2001; 9: 181-91.

Slavin J, Ghaneh P, Sutton R, Hartley M, Rowlands P, Garvey C, Hughes M, Neoptolemos JP.  Management of necrotizing pancreatitis.  World Journal of Gastroenterology 2001; 7: 476-481.

Magee CJ, Greenhalf W, Howes N, Ghaneh P, Neoptolemos JP.  Molecular pathogenesis of pancreatic ductal adenocarcinoma and clinical implications.  Surgical Oncology 2001; 10: 1-23.

Steinberg WM, Neoptolemos JP, Fölsch UR, Layer P. Controversies in clinical pancreatology. The management of severe gallstone pancreatitis. Pancreas 2001; 22: 221-229.

Bhatia M, Brady M, Shokuhi S, Christmas S, Neoptolemos JP, Slavin J. Inflammatory mediators in acute pancreatitis. Journal of Pathology 2000; 190: 117-125.

Howes N, Greenhalf W, Neoptolemos JP. Screening for early pancreatic ductal adenocarcinoma in hereditary pancreatitis. Medical Clinics of North America 2000; 84 (3): 719-38.

Slavin J, Ghaneh P, Sutton R, Neoptolemos JP. Pylorus preserving Kausch-Whipple resection: The successor of the classical Kausch-Whipple in chronic pancreatitis. Annali Italiani Di Chirurgia 2000; LXXI (1): 57-64.

Ghaneh P, Slavin J, Sutton R, Neoptolemos JP.  Adjuvant therapy for pancreatic cancer.  Swiss Surgery 2000; 6: 289-295.

Jones L, Ghaneh P, Humphreys M, Neoptolemos JP. The matrix metalloproteinases and their inhibitors in the treatment of pancreatic cancer.  Annals of the New York Academy of Sciences 1999; 880: 288-307.

Ghaneh P, Neoptolemos JP.  Exocrine pancreatic function following pancreatectomy. Annals of the New York Academy of Sciences 1999; 880: 308-318.

Sutton R, Slavin JP, Ghaneh P, Neoptolemos JP. Pancreatic disease; recent advances. European Journal of Gastroenterology and Hepatology 1999; 11: 33-36.

Ghaneh P, Kawesha A, Howes N, Jones L, Neoptolemos JP. Adjuvant therapy in pancreatic cancer. World Journal of Surgery 1999; 23: 937-945.

Ghaneh P, Neoptolemos JP.  Pancreatic exocrine insufficiency following pancreatic resection.  Digestion 1999; 60 (suppl I): 104-110.

Humphreys M, Greenhalf W, Neoptolemos JP, Ghaneh P.  The potential for gene therapy in pancreatic cancer. International Journal of Pancreatology 1999; 26: 5-21.

Slavin J, Ghaneh P, Jones L, Sutton R, Hartley M, Neoptolemos JP. The future of surgery for pancreatic cancer.  Annals of Oncology 1999; 10: (suppl 4): S285-S290.

Neoptolemos JP. Acute pancreatitis - Preface. Best Practice & Research in Clinical Gastroenterology 1999; 13: p.R7.

Raraty MGT, Petersen OH, Sutton R, Neoptolemos JP.  Intracellular free ionized calcium in the pathogenesis of acute pancreatitis. Best Practice & Research in Clinical Gastroenterology 1999; 13: 241-251.

Brady M, Christmas S, Sutton R, Neoptolemos J, Slavin J.  Cytokines and acute pancreatitis. Best Practice & Research in Clinical Gastroenterology 1999; 265-289.

Raraty MGT, Finch M, Neoptolemos J.  Acute cholangitis and pancreatitis secondary to common duct stones: management update.  World Journal of Surgery 1998; 22: 1155-116.

Wilson P, Manji M, Neoptolemos JP.  Acute pancreatitis as a model for sepsis. Journal of Antimicrobiol Chemotherapy 1998; 41, Suppl. A: 51-63.

Neoptolemos JP, Raraty M, Finch M, Sutton R. Acute pancreatitis: the substantial human and financial costs. Gut 1998; 42: 886-891.

Haycox A, Lombard M, Neoptolemos JP, Walley T. Current practice and future perspectives in detection and diagnosis of pancreatic cancer. Alimentary, Pharmacology & Therapeutics 1998; 12: 937-948.

Haycox A, Lombard M, Neoptolemos JP, Walley T. Current treatment and optimal patient management in pancreatic cancer. Alimentary, Pharmacology & Therapeutics 1998; 12: 949-964.

Slavin J, Neoptolemos JP. Review article: Controversies in the management of acute pancreatitis. Annals of the College of Surgeons of Hong Kong 1998; 2: No 2, 47-51.

Ghaneh P, Howes N, Neoptolemos JP. Pancreatic Cancer. Oncology Today. 1998; 18: 3-7.

Evans JD, Morton DG, NeoptolemosJP. Chronic pancreatitis and pancreatic carcinoma.   Potgraduate Medical Journal 1997; 73: 543-548.

Wilson PG, Ogunbiyi O, Neoptolemos JP. The timing of endoscopic sphincterotomy in gallstone acute pancreatitis. European Journal of Gastroenterology and Hepatology 1997; 9: 137-144.

Rougier P, Neoptolemos JP.   The need for a multidisciplinary approach in the treatment of advanced colorectal cancer.  European Journal of Surgical Oncology 1997; 23: 385-396.

Bramhall SR, Neoptolemos JP.  Adjuvant chemotherapy for pancreatic cancer.  International Journal of Pancreatology 1997; 21: 59-64.

Finch M, Howes N, Ellis I, Mountford R, Sutton R, Raraty M, Neoptolemos JP. Hereditary pancreatitis and familial pancreatic cancer. Digestion 1997; 58:  564-569.

Evans JD, Ghaneh P, Kawesha A, Neoptolemos JP.  The role of matrix metalloproteinases and their inhibitors in pancreatic cancer. Digestion, 1997; 58: 520-528.

Neoptolemos JP, Buchler M, Beger H. ESPAC satellite symposium. Digestion 1997; 58 501-502.

Evans J, Neoptolemos JP.  Pancreatic left resection.  Digestive Surgery 1996; 13:150-157.

Radley S, Pongracz J, Lord JM, Neoptolemos JP.  Bile acids and colorectal cancer.  Cancer Topics 1996; 10: 1-7.

Green N, Searle P, Young L, Kerr DJ, Neoptolemos JP.  Gene therapy for GI tract cancers.  GI Cancer1996; 2: 43-53.

Mirza DF, Neoptolemos JP, Modern management of gallstones.  Postgraduate Surgery 1996; 6: 14-18.

Winslet M, Imray C, Neoptolemos JP.  Biliary pancreatitis.  Hepatogastroenterology 1991; 38: 120-123. 

Morton D, Neoptolemos JP. Management of familial adenomatous polyposis.  (English).    Postepy Nauk Medycznych 1992; 5:225-232. 

Neoptolemos JP, Stonelake P, Radley S.  Endoscopic sphincterotomy for acute pancreatitis.   Hepatogastro-enterology 1993; 40:550-555.

Bramhall S, Neoptolemos JP.  Adjuvant therapy – pancreatic cancer.  Current Practice in Surgery 1994; 6:161-166.

Perissat J, Huibregtse K, Keane FBV, Russell RCG, Neoptolemos JP.  The management of bile duct stones in the era of laparoscopic cholecystectomy. British Journal of Surgery 1994; 81:789-810.

Bramhall SR, Neoptolemos JP.   Role of adjuvant chemotherapy and radiotherapy in pancreatic cancer.   Digestive Surgery 1994; 408-413.

Williams G, Neoptolemos JP.  Acute presentations and management of bile duct calculi.  Seminars in Laparoscopic Surgery 1995; 2:102-110.

Bramhall SR, Neoptolemos JP.  Advances in pancreatic cancer.  The Gastroenterologist 1995; 3:301-310.

Curran FC, Neoptolemos JP.  Acute biliary pancreatitis.  Annali Italiani Di Chirurgia 1995; LVVI:197-202.

Neoptolemos JP, Hofmann AF, Moossa AR.  Chemical treatment of stones in the biliary tree.  British Journal of Surgery 1986; 73:515-524. 

O’Doherty DR, Neoptolemos JP, Wood KF.  The role of surgery in the management of amyloid disease.  British Journal of Surgery 1987; 74:83-88. 

Nicholson MJ, Neoptolemos JP, Clayton H, Heagerty AM. Diet and colorectal cancer. International Clinical Nutrition Review 1988; 8: 180-197. 

Hall C, Rowley S, Neoptolemos JP.  Anastomosis or colostomy for low rectal cancers?   Postgraduate Medical Journal 1989; 65: 144-9. 

Neoptolemos JP, Rowley S.  Advantages in non-surgical treatment of bile duct stones. Hepatogastro-enterology 1989; 36: 311-314. 

Neoptolemos JP, Imray C, Hall C. Philosophers and stones in acute pancreatitis.   Digestive Diseases. 1990; 8:361-373. 

Winslet M, London NJM, Neoptolemos JP.  Management of necrotizing pancreatitis (English).  Postepy Nauk Medycznych 1990; 3: 130-136. 

Neoptolemos JP, Macpherson DS.  Pyogenic liver abscess. British Journal of Hospital Medicine 1981; 26:47-51. 

Goodman AJ, Neoptolemos JP.  Acute pancreatitis: An update. British Journal of Clinical Practice 1985; 39:7-11. 

Neoptolemos JP (Ed).  Cancer of the Pancreas.  Clinical Gastroenterology, London, Baillière Tindall, Vol 4, No 4 1990, (pp 215).

Lemoine N, Cooke T, Neoptolemos JP (Eds). Cancer: A Molecular Approach. Oxford, Blackwell Scientific, 1993 (pp 383).

Neoptolemos JP, Lemoine N (Eds).  Pancreatic Cancer:  Molecular & Clinical Advances.  Oxford, Blackwell Scientific 1996 (pp 346).

Beger HG,  Warshaw A, Carr-Locke DL, Russell RCG, Buchler M, Neoptolemos JP,  Saar M. (Eds).  The Pancreas (Two Volumes).  Boston, Blackwell Scientific 1998 (pp 1644).

Neoptolemos JP (Ed.). Acute Pancreatitis. Clinical Gastroenterology, London, Bailière Tindall 1999; Vol. 13, No. 2 (pp 152).

Gress TM, Neoptolemos JP, Lemoine NR, Real FX (Eds).  Exocrine pancreas cancer.  The European Pancreatic Cancer-Research Cooperative (PC-RC).  Felsenstein CCCP, Hannover.  2005 (pp 531).

Neoptolemos JP and Bhutani MS. Fast Facts. Pancreas and Biliary Tree. Health Press Abingdon. 2006 (pp127).

Neoptolemos JP and Ghaneh P (Eds). Cancer of the Pancreas. Best Practice & Research in Clinical Gastroenterology. London, Baillière Tindall, 2006.

Beger HG, Warshaw A, Büchler M, Kozarek R, Lerch M, Neoptolemos JP, Shiratori K, Whitcomb D. (Eds). The Pancreas, Second Edition.  Blackwell Publishing, Massachusetts, USA, 2008 (pp 1006).

Neoptolemos JP, Urrutia R, Abbruzzese JL, Büchler MW (Eds).  Pancreatic Cancer. Springer, New York, 2010 (pp1335).

BOOK CHAPTERS

Tonack S, Neoptolemos J, Costello E.  Principles and applications of proteomics in pancreatic cancer.  In:
Neoptolemos JP, Urrutia R, Abbruzzese JL, Büchler MW (Eds).  Pancreatic Cancer. Springer, New York, 2010, 509-533.
Greenhalf W, Neoptolemos J.  Genetic susceptibility and high risk groups for pancreatic cancer.  In: Neoptolemos JP, Urrutia R, Abbruzzese JL, Büchler MW (Eds).  Pancreatic Cancer. Springer, New York, 2010, 565-600.

Ghaneh P, Neoptolemos JP, Cunningham D.  Adjuvant chemotherapy in pancreatic cancer.  In: Neoptolemos JP, Urrutia R, Abbruzzese JL, Büchler MW (Eds).  Pancreatic Cancer. Springer, New York, 2010, 1051-1077.

Greenhalf W, Neoptolemos J.  Inherited genetics of pancreatic cancer and secondary screening.  In: Neoptolemos JP, Urrutia R, Abbruzzese JL, Büchler MW (Eds).  Pancreatic Cancer. Springer, New York, 2010, 1203-1235.
Ghaneh P, Greenhalf W, J Neoptolemos. Factors involved in carcinogenesis and prevention in hepatobiliary cancer. In: Sampliner, Kerr and Fong (Eds). Structure of GI Oncology: A Critical MDT Approach. In press.

Raraty M, Neoptolemos JP, Etiology and epidemiology of biliary acute pancreatitis. In: Beger HG, Warshaw A, Büchler M, Kozarek R, Lerch M, Neoptolemos JP, Shiratori K, Whitcomb D. (Eds). The Pancreas, Second Edition.  Blackwell Publishing, Massachusetts, USA, 2008, 154-162.

Connor S, Raraty M, Evans J, Neoptolemos JP.  Minimal-access surgical treatment of necrotizing pancreatitis and pancreatic abscess. In: Beger HG, Warshaw A, Büchler M, Kozarek R, Lerch M, Neoptolemos JP, Shiratori K, Whitcomb D. (Eds). The Pancreas, Second Edition.  Blackwell Publishing, Massachusetts, USA, 2008, 336-343.

Alexakis N, Ghaneh P, Neoptolemos JP.  Epidemiology of pancreatic cancer.  In: Beger HG, Warshaw A, Büchler M, Kozarek R, Lerch M, Neoptolemos JP, Shiratori K, Whitcomb D. (Eds). The Pancreas, Second Edition.  Blackwell Publishing, Massachusetts, USA, 2008, 573-582.

Greenhalf W, Vitone L, Neoptolemos JP.  Familial pancreatic cancer.  In: Beger HG, Warshaw A, Büchler M, Kozarek R, Lerch M, Neoptolemos JP, Shiratori K, Whitcomb D. (Eds). The Pancreas, Second Edition.  Blackwell Publishing, Massachusetts, USA, 2008, 591-600.

Ghaneh W, Neoptolemos JP.  Adjuvant chemotheraphy in pancreatic cancer.  In: Beger HG, Warshaw A, Büchler M, Kozarek R, Lerch M, Neoptolemos JP, Shiratori K, Whitcomb D. (Eds). The Pancreas, Second Edition.  Blackwell Publishing, Massachusetts, USA, 2008, 741-748.

Ghaneh P, Neoptolemos JP.  Pancreas Cancer.  In: MK Gospodarowicz, B O’Sullivan, LH Sobin (Eds). Prognostic Factors in Cancer (3rd Ed).  Wiley-Liss, Hoboken, New Jersey.  2006, 153-156 (353 pages).

Alexakis N, Neoptolemos JP.  Pancreatic cancer: epidemiology, risk factors, and therapeutic aspects.  In: A Ly, D Khayat (Eds) Cancers in Africa.  IARC 2006, 243-255.

Raraty MGT, Ghaneh P, Neoptolemos JP.  Adjuvant and neoadjuvant treatment of resectable pancreatic cancer: what is worth attempting?  In: JE Domingues-Munoz (Ed) Clinical Pancreatology for Practising Gastroenterologists and Surgeons.  Blackwell Publishing, Oxford, UK.  2005, 444-454.

Ghaneh P, Neoptolemos JP.  Pancreatic exocrine tumors.  In:  WM Weinstein, CJ Hawkey and J Bosch (Eds) Clinical Gastroenterology and Hepatology.  Elsevier Mosby.  2005, 521-533, 1191 pages

Alexakis N, Connor S, Ghaneh P, Sutton R, Evans J, Neoptolemos JP.  Complications of pancreatic surgery. In: NS Hakim and V Papalois (Eds) Surgical Complications: Diagnosis and Treatment.  Imperial College Press, London, UK. 

Hahn S, Vitone L, Greenhalf W, Bartsch D, Neoptolemos JP.  Familial pancreatic cancer syndromes.  In: TM Gress, JP Neoptolemos, NR Lemoine, FX Real (Eds) Exocrine pancreas cancer.  Felsenstein CCCP, Hannover.  2005, 44-61 (531 pages).

Shore S, Vimalachandran D, Neoptolemos JP, Costello E.  Proteomic analysis of pancreas samples using two-dimensional electrophoresis combined with mass spectrometry.  In: TM Gress, JP Neoptolemos, NR Lemoine, FX Real (Eds) Exocrine pancreas cancer.  Felsenstein CCCP, Hannover.  2005, 244-253 (531 pages).

Vitone L, Greenhalf W, Neoptolemos JP.  Secondary screening for pancreatic cancer in high risk groups.  In: TM Gress, JP Neoptolemos, NR Lemoine, FX Real (Eds) Exocrine pancreas cancer.  Felsenstein CCCP, Hannover.  2005, 310-329 (531 pages).

Ghaneh P, Neoptolemos JP.  Adjuvant therapy of pancreatic cancer.  In: TM Gress, JP Neoptolemos, NR Lemoine, FX Real (Eds) Exocrine pancreas cancer.  Felsenstein CCCP, Hannover.  2005, 364-381 (531 pages).

Greenhalf W, Vitone L, Neoptolemos JP.  Molecular diagnosis of pancreatic cancer in pancreatic juice.   In: TM Gress, JP Neoptolemos, NR Lemoine, FX Real (Eds) Exocrine pancreas cancer.  Felsenstein CCCP, Hannover.  2005, 404-425 (531 pages).

Alexakis N, Neoptolemos JP.  Chronic pancreatitis: endoscopic versus surgical procedures for pain relief.  In: RW Ammann, MW Büchler, G Adler, EP DiMagno, M Sarner (Eds) Pancreatitis: advances in pathobiology, diagnosis and treatment.  Proceedings of the Falk Sympoisum 143.  Springer, Dordrecht, The Netherlands.  2005, 191-205 (259 pages).

Doran H, Neoptolemos JP, Williams EMI, Sutton R.  Epidemiology of pancreatic neuroendocrine tumours.  In: CD Johnson and CW Imrie (Eds) Pancreatic Disease: Basic Sciences and Clinical Management.  Springer, London, UK.  2004, 5-17

Sutton R, Stocken DD, Dunn JA, Hickey H, Raraty MGT, Ghaneh P, Buckels J, Deakin M, Imrie CW, Friess H, Büchler MW, Neoptolemos JP.  Progress by collaboration: ESPAC studies.  In: In: CD Johnson and CW Imrie (Eds) Pancreatic Disease: Basic Sciences and Clinical Management.  Springer, London, UK.  2004, 57-69

Ghaneh P, Halloran C, Costello E, Neoptolemos JP.  Novel alternatives to chemotherapy in advanced disease: gene transfer.  In: CD Johnson and CW Imrie (Eds) Pancreatic Disease: Basic Sciences and Clinical Management.  Springer, London, UK.  2004, 99-120

Ghaneh P, Magee C, Neoptolemos JP.  Pancreatic Cancer.  In:  Evidence-Based Oncology, C Williams (Ed).  BMJ Books, London, 2003 247-272.

Slavin J, Neoptolemos JP.  Transduodenal sphincteroplasty.  In:  Operative Techniques in General Surgery, J van Heerden and D Farley (Eds).  W B Saunders Company, Philadelphia.

Raraty MGT, Magee CJ, Ghaneh P, Neoptolemos JP.  Adjuvant chemotherapy for pancreatic cancer.  In: J Permert and T Adrian (Eds) Controversies in Pancreatology.  Carlsson Communication, Stockholm, Sweden.  2003, 226-242

Alexakis N, Raraty MGT, Neoptolemos JP.  Who should do pancreatic cancer surgery?  An international perssepctive towards centralization.  In: J Permert and T Adrian (Eds) Controversies in Pancreatology.  Carlsson Communication, Stockholm, Sweden.  2003, 271-286

Magee CJ, Ghaneh P, Neoptolemos JP.  Surgical and medical therapy for pancreatic carcinoma.  In:  Best Practice and Research in Clinical Gastroenterology – G Adler (Ed).  Ballière Tindall.  2002; 16(3): 435-455.

Neoptolemos JP, Ghaneh P, Sutton R, Hartley M, Hughes M, Garvey CJ, Lombard M, Smart H, Gilmore I.  Integrated radiology for surgical resection in chronic pancreatitis.  In:  MW Büchler and H Friess and P Malfertheiner (Eds).  Chronic Pancreatitis Novel Concepts in Biology and Therapy.    Blackwell Wissenschafts-Verlag, Oxford, UK.  2002; 277-295.

Neoptolemos JP, Ghaneh P, Slavin J, Sutton R.  Terapia adiuvante nel cancro del pancreas.  In: Italian Association for the Study of Pancreas Diseases, XXIV Concress Proceedings. Neoplasi, Pancreatiche: Esocrine ed Endocrine. Forma Communications Editore, Napoli, Italy. 2001; 149-163.

Ghaneh P, Smith D, Almond J, Moffitt D, Dunn J, Slavin J, Sutton R, Bassi C, Paolo Pederzoli, Beger HG, Link KH, Friess H, Büchler, Neoptolemos JP.  European Adjuvant Trials.  In:  M.D. Anderson Solid Tumor Oncology Series.  DB Evans, PWT Pisters, JL Abbruzzese and RE Pollock (Eds).  Springer-Verlag, New York, USA.  2001; 255-267.

Neoptolemos JP.  Acute pancreatitis.  In: Therapeutic Gastrointestinal Endoscopy.  D Westaby and M Lombard (Eds). Martin Dunitz, London, UK.  2001; 181-195.

Slavin J, Neoptolemos JP.  Oncology.  In: Integrated Basic Surgical Sciences, Toouli J, Russel C, Devitt P, Ingham-Clark C (Eds).  Arnold, London 2000; 502-525.

Slavin J, Sutton R, Ward J, Hartley M, Neoptolemos JP.  Acute pancreatitis. In: A Textbook of Gastroenterology (Vol IV), Familiari L, Sahel J (Eds).  Masson, Milan 2000; 199-223.

Neoptolemos JP. Acute pancreatitis - Preface.  In:  Neoptolemos JP (Ed.) Best Practice & Research in Clinical Gastroenterology 1999; 13: R7.

Brady M, Christmas S, Sutton R, Neoptolemos JP, Slavin J.  Cytokines in acute pancreatitis.  In: Neoptolemos JP (Ed.) Best Practice & Research in Clinical Gastroenterology 1999; 265-289.

Raraty M, Petersen OH, Sutton R, Neoptolemos JP.  Intracellular free ionized calcium changes in the pathogenesis of acute pancreatitis. In: Neoptolemos JP (Ed.) Best Practice & Research in Clinical Gastroenterology 1999; 13, 2: 241-251.

Neoptolemos JP. Tumours, cysts, ulcers, sinuses.  In: Mann CV, Russell RCG, Williams NS (Eds.). Bailey and Love’s Short Practice of Surgery. London, Arnold, 23rd Edition 1999; 23: 147-162.

Ward JB, Slavin J, Neoptolemos JP.  Biliary acute pancreatitis and the role of endoscopy.  In:  Büchler MW, Uhl W, Friess H, Malfertheiner P (Eds).  Acute Pancreatitis.  Novel concepts in biology and therapy.  Blackwell Science, Berlin 1999; 355-358.

Ghaneh P, Evans J, Kawesha A, Foster C, Neoptolemos JP. Molecular factors for prognosis in pancreatic cancer. In:  Beger HG, Link KH (Eds).  2nd International Congress on Gastroenterological Carcinogenesis, Monduzzi Editore, Bologna. 1999; 97-107.

Wilson P,  Neoptolemos JP.  Gallstone-associated Acute Pancreatitis.  In: Howard J, Idezwki Y, Ihse I, Prinz RA. (Eds).  Surgical Diseases of the Pancreas. Boston, Williams and Wilkins, 3rd Edition. 1998: 224-249.

Z’Graggen K, Wilson PG, Neoptolemos JP, Büchler M.  Diagnosis of acute pancreatitis: Clinical aspects.  In: Beger HG, Warshaw A, Carr-Locke DL, Russell RCG, Büchler M, Neoptolemos JP, Saar M. (Eds).  The Pancreas (Two volumes).  Boston, Blackwell Scientific 1998; 466-471.

Neoptolemos JP, Ogunbiyi O, Wilson PG, Carr-Locke DL. Etiology, pathogenesis, natural history and treatment of biliary acute pancreatitis.  In: Beger HG, Warshaw A, Carr-Locke, DL, Russell RCG, Büchler M, Neoptolemos JP, Saar M. (Eds).  The Pancreas (Two volumes).  Boston, Blackwell Scientific 1998; 521-543.

Bramhall S, Dunn J, Neoptolemos JP.  Epidemiology of pancreatic cancer.  In: Beger HG, Warshaw A, Carr-Locke DL, Russell RCG, Büchler M, Neoptolemos JP, Saar M. (Eds).  The Pancreas. (Two volumes).  Boston, Blackwell Scientific 1998; 889-906.

Neoptolemos JP, Bramhall S, Kerr DJ.  Adjuvant treatment in pancreatic cancer: combined treatment modalities.  In:  Beger HG, Warshaw A, Carr-Locke DL, Russell RCG, Büchler M, Neoptolemos JP, Saar M (Eds).  The Pancreas. (Two volumes).  Boston, Blackwell Scientific 1998; 1104-1119.

Evans JD, Kawesha A, Ghaneh P, Neoptolemos JP.  Metalloproteinases and sromal biology in cancer. In: Johnson CD and Imrie CW (Eds.) Pancreatic Disease Towards the Year 2000, Springer-Verlag 1998; 281-298.

Finch MD and Neoptolemos JP.  Pancreatic resection for pancreatic cancer:  outcome in specialist units. In: Johnson CD and Imrie CW (Eds.) Pancreatic Disease Towards the Year 2000, Springer-Verlag 1998; 385-396.

Ghaneh P, Kawesha A, Evans JD, Neoptolemos JP.  Adjuvant therapy in pancreatic cancer. In: Johnson CD and Imrie CW (Eds.) Pancreatic Disease Towards the Year 2000, Springer-Verlag 1998; 431-444.

Williams G, Neoptolemos JP. Cholangitis.  In:  Taylor MB, Golan J, Steer M, Wolfe M, (Eds). Gastrointestinal emergencies (2nd Ed.).  Boston, Williams and Wilkins 1997; 275-288.

Wilson PG, Evans JD, Neoptolemos JP. Endoscopic retrograde cholangiopancreatography in acute pancreatitis: indications and limitations.  In : Malfertheiner P, Dominguez-Muñoz JE, Schulz U, Lippert H. (Eds.) Diagnostic procedures in pancreatic disease. Berlin, Springer 1997: 57-66

Wilson PG, Evans DJ, Ogurbyi O, Neoptolemos JP.  Acute biliary pancreatitis.  In: Testoni A, Tittobello A (Eds).  Endoscopy in pancreatic disease in diagnosis and therapy.  Chicago, Mosby-Wolfe 1997; 117-124.

Wilson PG, Finch M, Neoptolemos JP. Common bile duct emergencies. Endoscopic treatment. In: Schein M, Wise L. (eds.) Crucial Controversies in Surgery 1997. Basel, Karger Landes Systems, 1997: 187-194.

Raraty MGT, Pope IM, Finch M, Neoptolemos JP, Choledocholithiasis and gallstone pancreatitis. In: Ballière’s Clinical Gastroenterology of the Biliary Tract.  Pitt HA (ed.) Ballière Tindall 1997: ll: 663-683.

Evans J, Bramhall S,  Neoptolemos JP.  Molecular biology of pancreatic diseases.  In:  Carter D, Trede M (eds).  Surgery of the Pancreas.  London, Churchill Livingstone.  2nd edition.  1997; 149-164.

Bramhall S, Stamp G, Lemoine N, Neoptolemos JP.  The matrix metalloproteinases and their inhibitors in pancreatic cancer.   In:  Neoptolemos JP, Lemoine N (Eds).  Pancreatic Cancer: Molecular and Clinical Advances.  Blackwell Scientific, Oxford 1996, 68-91.

Searle P, Green N, Young L, Kerr DJ, Neoptolemos JP.  Gene-transfer therapy and pancreatic cancer.  In: Neoptolemos JP, Lemoine N (Eds).  Pancreatic Cancer: Molecular & Clinical Advances.  Blackwell Scientific, Oxford 1996, 194-213.

Bramhall S, Neoptolemos JP.  Adjuvant treatment of pancreatic cancer.   In:  Neoptolemos JP, Lemoine N (Eds).  Pancreatic Cancer: Molecular & Clinical Advances.  Blackwell Scientific, Oxford 1996, 288-308.

Curran F, Earle H, Neoptolemos JP.  Small bowel tumours – carcinoma, carcinoid and lymphoma.  In:  Taylor I, Guillou P, Cooke T. (Eds).  Essential General Surgical Oncology.  London, Churchill Livingstone 1996, 309-325.

Neoptolemos JP, Ching CH, Rhodes JM, Lemoine N.  Cancer of the pancreas and ampulla of Vater.  In: Fielding JWL, Allum WH, (Eds.) Pre-malignancy and Early Cancer in General Surgery.  Oxford, Oxford University Press 1996, 66-100.

Neoptolemos JP, Lemoine N, Bramhall S.  Molecular biology: Diagnostic and prognostic perspectives in pancreatic cancer.  In: Beger HG, Büchler M, Schoenberg M. (Eds).  Cancer of the pancreas.  Universitätsverlag, Ulm, 1996; 199-211.

Neoptolemos JP, Bramhall S, Kerr D.  Principles of adjuvant treatment in cancer of the pancreas.  In:  Beger HG, Büchler  M, Schoenberg M. (Eds).  Cancer of the pancreas. Universitätsverlag, Ulm, 1996; 470-487.

Bramhall S, Neoptolemos JP.  The role of matrix metalloproteinases and their inhibitors in pancreatic cancer.  In: Dervenis CG (Ed).  Advances in Pancreatic Disease.  Stuttgart, Georg Thieme Verlag 1996:42-55.

Bramhall S, Neoptolemos JP.  Adjuvant treatment in pancreatic cancer. In: Dervenis CG (Ed).  Advances in Pancreatic Disease.  Stuttgart, Georg Thieme Verlag 1996: 339-351.

Ogunbiyi G, Neoptolemos JP.  Endoscopy in the treatment of biliary acute pancreatitis. In: Dervenis CG (Ed).  Advances in Pancreatic Disease.  Stuttgart, Georg Thieme Verlag 1996: 170-181.

Neoptolemos JP.  Pancreatic cancer.  In: Pounder RE.  Current Diagnosis and Therapy.  London, Current Medicine Inc., 1995, 296-297.

Neoptolemos JP.  Acute Pancreatitis.  In: Pounder RE.  Current Diagnosis and Therapy.  London, Current Medicine Inc., 1995, 298-299.

Neoptolemos JP.  Chronic pancreatitis.  In: Pounder RE.  Current Diagnosis and therapy.  London, Current Medicine Inc., 1995, 300-301.

Ogunbiyi OA, Neoptolemos JP.   Endoscopy in the treatment of acute pancreatitis.  In: Forni E, Meriggi (Eds).  Selected topics of HPB Surgery and Medicine.  Pavia, IRCCS, 1995: 141-144.

Ogunbiyi G, Neoptolemos JP.  Endoscopy in the treatment of biliary acute pancreatitis.  In: Drobrilla G, Felder M, De Pretis G, (Eds).   Advances in Hepatobiliary and Pancreatic Diseases.  Kluwer Academic Publishers, Dordrecht, Holland, 1995, 179-193.

Neoptolemos JP. The biliary system.  In: Farndon J, Keen G. (Eds). Operative Surgery and Management.  3rd Edition. London, Butterworths, 1994, 275-294.

Neoptolemos JP.  Endoscopic retrograde cholangio-pancreatography in acute pancreatitis.  In: Bassi C, Pederzoli P, Cavallini G. (Eds).  Facing the Pancreatic Dilemma.  Berlin, Springer-Verlag, 1994, 433-447.

Neoptolemos JP, Radley S.  Endoscopic treatment of acute pancreatitis.  In:  Gazzaniga GM (ed.).  What’s New in Pancreatic Diseases Berlin, Thieme Verlag, 1994, 17-23.

Neoptolemos JP, Bouchier IAD.  Cholecystitis and choledocholithiasis.  In: Bouchier IAD, Allan RN, Hodgson NJF, Keighley MRB (Eds) Gastroenterology: Clinical Science and Practice, London, Saunders, 2nd Edition, 1993, 1732-1764.

Bouchier IAD, Neoptolemos JP.   Clinical features and non-surgical treatment of gallstones.  In: Bouchier IAD, Allan RN, Hodgson NJF, Keighley MRB (Eds).  Gastroenterology: Clinical Science and Practice.  London, Saunders, 2nd Edition, 1993, 1719-1732.

Neoptolemos JP, Hendrickse C.  Biliary bypass for pancreatic cancer.  In: Beger H, Buchler M, Malfertheiner P. (eds). Standards of Pancreatic Surgery.   Berlin, Springer-Verlag, 1993, 614-630.

Morton D, MacDonald F, Neoptolemos JP.  Colorectal cancer.  In:  Lemoine N, Cooke T, Neoptolemos JP (Eds).  Cancer: A Molecular Approach.  Oxford, Blackwell Scientific, 1993, 116-141.

Neoptolemos JP.  Endoscopic retrograde cholangio-pancreatography in necrotizing  pancreatitis.  In: Bradley EL (Ed.) Acute Pancreatitis: Diagnosis and therapy.  New York, Raven Press, 1993, 69-76.

Rowley S, Newbold M, Neoptolemos JP.  Oncogenes, growth factors and prognostic indicators in colorectal cancer.  In: Nyhus LM (Ed.) Surgery Annual 1992 (Vol 2).  Norwalk, Connecticut, Appleton-Century-Crofts, 1992, 59-85.

Neoptolemos JP.  Cancer of the pancreas and gallbladder.  In: Burn I and Wellwood J. (Eds).  Operative Cancer Surgery.  Vol. 1.  Gastro-intestinal tract.   London, Farrand Press Ltd 1992, 75-108.

Morton D, Isgar B, Baker PRB, Neoptolemos JP.  Oncogenes in surgery. In: Taylor I & Johnson CD (Ed).  Recent Advances In Surgery. Volume 15, London, Churchill Livingstone 1992, 87-105.

Neoptolemos JP.  Pancreatic disease. In: Pounder RE (Ed). Recent Advances in Gastroenterology.  Vol. 9.  London, Churchill Livingstone, 1992, 85-104.

Winslet M, Neoptolemos JP.  Endoscopic management of bile duct stones.  In: Carr-Locke DL (Ed).  Clinical Gastroenterology.  Endoscopy. London, Bailliere Tindall, 1991, Vol 5, No 1, 99-129.

Isgar B, Neoptolemos JP.  Radiotherapy and chemotherapy in the treatment of pancreatic cancer. In: Johnson CD, Imrie C (Eds). Pancreatic Disease: Progress and Prospects. London, Springer-Verlag, 1991, 103-113.

Lavelle-Jones MA, Neoptolemos JP.  Recent advances in the treatment of acute pancreatitis.  In:  Nyhus LM (Ed).  Surgery Annual, 1990.   Norwalk, Connecticut, Appleton-Century-Crofts, 1990, 235-261.

Neoptolemos JP, Winslet M.  Pancreatic ascites.  In: Beger H, Buchler M.   Ditschuneit H, Malfertheiner P.  (Eds) Chronic Pancreatitis.  Berlin, Springer-Verlag, 1990,  268-279.

Neoptolemos JP.  The role of endoscopic sphincterotomy and surgery in the treatment of acute gallstone pancreatitis.  In:  Zentler-Munro PL (Ed).  Advances in  Pancreatitis.  Southampton, Duphar, 1989, 33-53.

Neoptolemos JP, Carr-Locke DL.  ERCP in acute cholangitis and pancreatitis.  In: Jacobson IM (Ed).  ERCP:  Diagnostic and Therapeutic Applications.  New York, Elsevier, 1989, 93-128.

Hofmann AF, Gurantz D, Hagey LR, Schteingart C, Yoon YB, Clayton LR, Palmer KR, Neoptolemos JP, Rossi SS, Steinbach JH, Clerici C.  The key of bile acid biotransformation in bile acid dependent bile flow.  In: Davison JS, Shaffer E. (Eds). Gastrointestinal and Hepatic Secretions: Mechanisms and Control.  The University of Calgary Press, 1988, 18-23.

Hofmann AF, Gurantz D, Hagey LR, Schteingart C, Yoon YB, Neoptolemos JP, Rossi SS, Steinbach JH, Clerici C.  The relationship between bile acid biotransformation and bile acid dependent bile flow.  In:  Paumgartner G, Stiehl A, Gerok W (Eds).  Bile acids and the liver.  MTP Press, Lancaster 1987, 183-195.

EDITORIALS (All invited)

Neoptolemos JP.  Per-operative cholangiography.  Annals of the Royal College of Surgeons of England 1991; 73:43.

Neoptolemos JP, Isgar B.  Cholesterolosis and acute pancreatitis.  HPB Surgery 1991; 3: 217-20.

Neoptolemos JP.  Biliary pancreatitis. Italian Journal of Gastroenterology 1991; 23:570-573.

Neoptolemos JP.  Bile duct obstruction secondary to chronic pancreatitis.  Annals of the Royal College of Surgeons of England 1992; 74; 123-125.

Neoptolemos JP, Radley S.  Long-term follow-up of choledocho-duodenostomy.  HPB Surgery 1992; 5:157-159.

Neoptolemos JP.  Endoscopic sphincterotomy in acute pancreatitis.  British Journal of Surgery 1993, 80:547-549.

Neoptolemos JP.  Relief of malignant obstructive jaundice.  Surgical Oncology 1993; 2: 97-98.

Neoptolemos JP.  Adjuvant treatment for pancreatic cancer.  British Journal of Surgery 1995; 82:1012-1014.

Cruickshank N, Morton DG, Matthews G, Neoptolemos JP.  Screening and prevention of colorectal cancer – fact or fantasy! Surgery 1996; 14: ii.

Büchler M, Friess H, Baeur HU, Neoptolemos JP.  Surgical treatment of chronic pancreatitis: new standards.  Digestive Surgery1996; 13:66.

Neoptolemos JP, Büchler M, Beger H. ESPAC satellite symposium. Digestion 1997; 58: 501-502.

Finch M, Neoptolemos JP. Early ERCP in Biliary Pancreatitis? HPB International, 1998;11: 129-131.

Neoptolemos JP.  Endoscopic treatment of acute and chronic pancreatitis. Italian Journal of Gastroenterology and Hepatology 1998; 30: 556.

Neoptolemos JP, Klinkenbijl J, Farthmann E, Beger H. Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region - Phase III trial of the EORTC Gastrointestinal Tract Cancer Cooperative Group - Discussion. Annals of Surgery 1999; 230: 782-84.

Sutton R, Slavin JP, Neoptolemos JP.  The future of academic surgery.  NZ Med J 2000; 113: 199-200.

Neoptolemos JP.  The International Association of Pancreatology and the New Millennium.  Pancreatology 2001; 1: 2.

Neoptolemos JP.  Third International Symposium on Inherited Diseases of the Pancreas.  Pancreatology 2001; 1: 5.

Polk HC Jr, Bowden TA Jr, Rikkers LF, Balch CM, Organ CH, Murie JA, Pories WJ, Büchler MW, Neoptolemos JP, Fazio VW, Schwartz SI, Cameron JI, Kelly KA, Grosfeld JL, McFadden DW, Souba WW, Pruitt BA Jr, Johnston KW, Rutherford RB, Arregui ME, Scott-Conner CF, Warshaw AL, Sarr MG, Cuschieri A, McFadyen BV, Tompkins RK.  Scientific date from clinical trials: investigators’ responsibilities and rights.  American Journal of Surgery 2002; 183: 605-6; Annals of Surgical Oncology 2002; Archives of Surgery 2002; 137: 639-640; 9: 421-422; British Journal of Surgery 2002; 89: 678-9; Digestive Surgery  2002; 19: 157-159; Disorders of Colon Rectum 2002; Journal American Colorectal Surgery 2002; 194: 851-2; 45: 725-6; Journal of Gastrointestinal Surgery 2002;6: 512-3; Journal of Trauma 2002; 52: 1017-8; Journal of Vascular Surgery 2002; 35: 1303-1304; Surgical Laparoscopic Endoscopy Percutaneous Techniques 2002; 12: 2-145; World Journal of Surgery 2002; 26: 637-8;.

Howes N, Neoptolemos JP.  Risk of pancreatic ductal adenocarcinoma in chronic pancreatitis.  Gut 2002; 51: 765-766.

Neoptolemos JP.  Pancreatic Cancer – A major health problem requiring centralization and multi-disciplinary team-work for improved results.  Digestive and Liver Disease 2002; 34: 692-5.

Raraty MG, Neoptolemos JP. Compartments that cause the real damage in severe acute pancreatitis. American Journal of Respiratory and Critical Care Medicine 2003; 168(2):141-2.

Connor S, Neoptolemos JP.  Surgery for pancreatic necrosis: “whom, when and what”.  World Journal of Gastroenterology 2004; 10(12):1697-98.

Connor S, Neoptolemos JP.  Laparoscopy is still necessary in the assessment of peri-ampullary neoplasia.  Pancreatology 2004; 4(5):415-416.

Neoptolemos JP. Is endoscopic ultrasonography superior to multidetector CT for assessing pancreatic cancer?  Nature Clinical Practice Oncology 2005; 2:78-79.

Neoptolemos JP, Nordback I.  Pancreatitis.  Scandinavian Journal of Surgery.  2005; 94:87

Greenhalf W, Neoptolemos JP.  Increasing survival rates of patients with pancreatic cancer by earlier identification.  Nature Clinical Practice Oncology 2006; 3(7):346-7.

Ghaneh P, Neoptolemos JP.  A new approach to managming intraductal papillary mucinous pancreatic neoplasms.   Gut 2007; 56(8):1041-4.

Ghaneh P, Tudur-Smith C, Neoptolemos JP. Comment on "adjuvant therapy in pancreatic cancer: a critical appraisal". Drugs. 2007; 67(17):2487-90; discussion 2491-3.

Bland KI, Rikkers LF, Lillemoe KD, Balch CM, Edmunds LH, Murie J, Warnock GL, Waddell JP, Buchler MW, Neoptolemos JP, et al.  Consensus statement on mandatory registration of clinical trials
Br J Surg 2007; 94: 511-512; Plast Reconstr Surg 2007; 119: 1100-1101.

Bland KI, Rikkers LF, Lillemoe KD, Balch CM, Jr LHE, Murie J, Warnock GL, Waddell JP, Weigelt JA, Buchler MW, et al.  Mandatory registration of clinical trials.  J Am Coll Surg 2007; 204: 654-655

Neoptolemos JP.  Clinical evidence does not support the use of adjuvant radiotherapy in pancreatic cancer.  Nat Clin Pract Oncol 2008; 5: 431-431

Neoptolemos JP, Halloran CM. Surgical oncology: PBD-better stents in specialized centers are needed. Nat Rev Clin Oncol. 2010; 7(5):244-6.