Clinical & Translational Research > Pancreatic Cancer > Professor Paula Ghaneh

Professional Memberships 

• British Association for Cancer Research (BACR) (Member)
• Association of Surgeons of Great Britain and Ireland (Member)
• Association of Upper GI Surgeons (Member)
• British Medical Association (Member)
• European Pancreatic Club (Member)
• Medical Defence Union (Member)
• Pancreatic Society of Great Britain and Ireland (Member)
• Royal College of Surgeons of Edinburgh (Member)
• Royal College of Surgeons of England (Member)

• Dive C, Smith RA, Garner E, Ward T, George-Smith SS, Campbell F, Greenhalf W, Ghaneh P, Neoptolemos JP. (2010) Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer. British Journal of Cancer,102(),pp.577-82 

• Huggett MT, Ghaneh P, Pereira SP (2010) Drainage and bypass procedures for palliation of malignant diseases of the upper gastrointestinal tract. Clinical Oncology,22(),pp.755-63 

• Neoptolemos JP, Stocken DD, Bassi C, Ghaneh P, Cunningham D, Goldstein D, Padbury R, Moore MJ, Gallinger S, Mariette C, Wente MN, Izbicki JR, Friess H, Lerch MM, Dervenis C, Oláh A, Butturini G, Doi R, Lind PA, Smith D, Valle JW, Palmer DH, Buckels JA, Thompson J, McKay CJ, Rawcliffe CL, Büchler MW; European Study Group for Pancreatic Cancer. (2010) A randomized controlled trial of adjuvant chemotherapy using 5-fluorouracil with folinic acid versus gemcitabine and in patients with resectable pancreatic cancer JAMA. Journal of the American Medical Association,304(),pp.1073-81 

• Raraty MG, Halloran CM, Dodd S, Ghaneh P, Connor S, Evans J, Sutton R, Neoptolemos JP (2010) Minimal access retroperitoneal pancreatic necrosectomy: improvement in morbidity and mortality with a less invasive approach. Annals of Surgery,251(),pp.787-93 

• Sultana A, Tudur Smith C, Cunningham D, Starling N, Neoptolemos JP and Ghaneh P (2007) Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer. Journal of Clinical Oncology,(),pp.2607-2615 

• Sultana A, Smith C T, Cunningham D, Starling N, Tait D, Neoptolemos J P and Ghaneh P (2007) Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy. British Journal of Cancer,96(8),pp.1183-1190 

• Humphreys MJ, Ghaneh P, Greenhalf W, Campbell F, Clayton TM, Everett P, Huber BE, Richards CA, Ford MJ, Neoptolemos JP (2001) Hepatic intra-arterial delivery of a retroviral vector expressing the cytosine deaminase gene, controlled by the CEA promoter and intraperitoneal treatment with 5-fluorocytosine suppresses growth of colorectal liver metastases. Gene Ther,8(16),pp.1241-1247 

• Ghaneh P, Greenhalf W, Humphreys M, Wilson D, Zumstein L, Lemoine NR, Neoptolemos JP (2001) Adenovirus-mediated transfer of p53 and p16INK4a results in pancreatic cancer regression in vitro and in vivo. Gene Ther,8(3),pp.199-208

• Dive C, Smith RA, Garner E, Ward T, George-Smith SS, Campbell F, Greenhalf W, Ghaneh P, Neoptolemos JP. (2010) Considerations for the use of plasma cytokeratin 18 as a biomarker in pancreatic cancer. British Journal of Cancer,102(),pp.577-82 

• Neoptolemos JP, Stocken DD, Bassi C, Ghaneh P, Cunningham D, Goldstein D, Padbury R, Moore MJ, Gallinger S, Mariette C, Wente MN, Izbicki JR, Friess H, Lerch MM, Dervenis C, Oláh A, Butturini G, Doi R, Lind PA, Smith D, Valle JW, Palmer DH, Buckels JA, Thompson J, McKay CJ, Rawcliffe CL, Büchler MW; European Study Group for Pancreatic Cancer. (2010) A randomized controlled trial of adjuvant chemotherapy using 5-fluorouracil with folinic acid versus gemcitabine and in patients with resectable pancreatic cancer JAMA. Journal of the American Medical Association,304(),pp.1073-81 

• Huggett MT, Ghaneh P, Pereira SP (2010) Drainage and bypass procedures for palliation of malignant diseases of the upper gastrointestinal tract. Clinical Oncology,22(),pp.755-63 

• Raraty MG, Halloran CM, Dodd S, Ghaneh P, Connor S, Evans J, Sutton R, Neoptolemos JP (2010) Minimal access retroperitoneal pancreatic necrosectomy: improvement in morbidity and mortality with a less invasive approach. Annals of Surgery,251(),pp.787-93 

• Thomas A, Dajani K, Neoptolemos JP, Ghaneh P (2010) Adjuvant Therapy in Pancreatic Cancer. Digestive diseases,28(),pp.684-692 

• Yan, L., Tonack, S., Smith, R., Dodd, S., Jenkins, R. E., Kitteringham, N., Greenhalf, W., Ghaneh, P., Neoptolemos, J. P. and Costello, E. (2009) Confounding Effect of Obstructive Jaundice in the Interpretation of Proteomic Plasma Profiling Data for Pancreatic Cancer. Journal of Proteome Research,8(),pp.142-148 

• Smith RA, Bosonnet L, Raraty M, Sutton R, Neoptolemos JP, Campbell F ,Ghaneh P (2009) 'Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma'. American Journal of Surgery,167(),pp.466-472 

• Yan L, Tonack S, Smith R, Dodd S, Jenkins R, Kitteringham N, Greenhalf W, Ghaneh P, Neoptolemos JP, Costello E (2009) The confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling data for pancreatic cancer. Journal of Proteome Research,8(),pp.142-148 

• Neoptolemos JP, Stocken DD, Tudur Smith C, Bassi C, Ghaneh P, Owen E, Moore M, Padbury R, Doi R, Smith D, Büchler MW. (2009) Adjuvant 5-fluorouracil and folinic acid versus observation for pancreatic cancer: composite data from the ESPAC-1 and -3(v1) Trials. British Journal of Cancer,100(),pp.246-250 

• Sakka N, Smith R, Whelan P, Ghaneh P, Sutton R, Raraty M, Campbell F, Neoptolemos JP (2009) A preoperative prognostic score for resected pancreatic and periampullary neuroendocrine tumours. Pancreatology,9(),pp.670-676 

• Dajani K, O'Reilly DA, Carino Nde L, Ghaneh P, Poston G, Wu A (2009) The prognostic significance of the preoperative full blood count after resection of colorectal liver metastases. HPB Surgery,(),pp. 

• Campbell F, Smith RA, Whelan P, R Sutton, Raraty M, Neoptolemos JP, Ghaneh P (2009) Classification of R1 resections for pancreatic cancer: the prognostic relevance of tumour involvement within 1 mm of a resection margin. Histopathology,55(),pp.277-283 

• R Carter, DD Stocken P Ghaneh, S Bramhall, A Olah, D Kelemen, C Bassi, H Friess, C Dervenis, L, MW Büchler, JP Neoptolemos (2009) Longitudinal Quality of Life Data can provide Insights on the Impact of Adjuvant Treatment for Pancreatic Cancer – Subset Analysis of the ESPAC-1 Data. International Journal of Cancer,124(),pp.2960-2965 

• de Liguori Carino N, O'Reilly DA, Dajani K, Ghaneh P, Poston GJ, Wu AV (2009) Perioperative use of the LiMON method of indocyanine green elimination measurement for the prediction and early detection of post-hepatectomy liver failure. European Journal of Surgical Oncology,35(),pp.957-962 

• Sultana A, Shore S, Vinjamuri S, Evans JC, Tudur Smith C, Chauhan S, Bosonnet L, Garvey C, Neoptolemos JP, Ghaneh P (2009) Randomised Phase I/II trial assessing the safety and efficacy of radio labelled anti-carcinoembryonic antigen antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma. BMC cancer,9(),pp.66 

• Halloran C M, Ghaneh P, Connor S, Sutton R, Neoptolemos J P and Raraty M G T (2008) Carbohydrate antigen 19.9 accurately selects patients for laparoscopic assessment to determine resectability of pancreatic malignancy. British Journal of Surgery,95(4),pp.453-459

• Smith R A, Bosonnet L, Ghaneh P, Sutton R, Evans J, Healey P, Garvey C, Hughes M, Raraty M, Campbell F and Neoptolemos J P (2008) The platelet-lymphocyte ratio improves the predictive value of serum CA19-9 levels in determining patient selection for staging laparoscopy in suspected periampullary cancer. Surgery,143(5),pp.658-666

• Smith RA, Bosonnet L, Ghaneh P, Raraty M, Sutton S, Campbell F and Neoptolemos JP (2008) Preoperative CA19-9 levels and lymph-node ratio are independent predictors of survival in patients with resected pancreatic ductal adenocarcinoma. Digestive Surgery,25(),pp.226-232 

• Sultana A, Ghaneh P, Cunningham D, Starling N, Neoptolemos JP and Tudur Smith C (2008) Gemcitabine based combination chemotherapy in advanced pancreatic cancer- Indirect comparison. ,(),pp.  http://www.biomedcentral.com/1471-2407/8/192

• Smith R A, Ghaneh P, Sutton R, Raraty M, Campbell F and Neoptolemos J P (2008) Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio. Journal of Gastrointestinal Surgery,12(8),pp.1422-1428

• Murphy JA, Criddle DN, Sherwood M, Chvanov M, Mukherjee R, McLaughlin E, Booth D, Gerasimenko JV, Raraty MG, Ghaneh P, Neoptolemos JP, Gerasimenko OV, Tepikin AV, Green GM, Reeve JR Jr, Petersen OH and Sutton R (2008) Direct activation of cytosolic Ca(2+) signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology,135(),pp.632-41 

• de Liguori Carino N, van Leeuwen BL, Ghaneh P, Wu A, Audisio RA and Poston GJ (2008) Liver resection for colorectal liver metastases in older patients. Critical Reviews in Oncolology/Hematolology,67(),pp.273-8 

• Sultana A, Tudur Smith C, Cunningham D, Starling N, Neoptolemos JP and Ghaneh P (2008) Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer- results of secondary endpoints analyses. British Journal of Cancer,99(),pp.6-13 

• Murphy J, Vimalachandran D and Ghaneh P (2008) Anterior abdominal wall abscess secondary to subcutaneous gallstones. Case Reports in Gastroenterology,(),pp.219-223  http://content.karger.com/ProdukteDB/produkte.asp?typ=pdf&doi=137375

• Al-Sarireh B, Ghaneh P, Gardner-Thorpe J, Raraty M, Hartley M, Sutton R and Neoptolemos J P (2008) Complications and follow-up after pancreas-preserving total duodenectomy for duodenal polyps. British Journal of Surgery,95(12),pp.1506-1511

• Smith R A, Bosonnet L, Ghaneh P, Raraty M, Sutton R, Campbell F and Neoptolemos J P (2008) Preoperative CA19-9 levels and lymph node ratio are independent predictors of survival in patients with resected pancreatic ductal adenocarcinoma. Digestive Surgery,25(3),pp.226-232

• Sultana A, Ghaneh P, Cunningham D, Starling N, Neoptolemos J P and Smith C T (2008) Gemcitabine based combination chemotherapy in advanced pancreatic cancer-indirect comparison. Bmc Cancer,8(),pp

• Smith R A, Dajani K, Dodd S, Whelan P, Raraty M, Sutton R, Campbell F, Neoptolemos J P and Ghaneh P (2008) Preoperative Resolution of Jaundice Following Biliary Stenting Predicts More Favourable Early Survival in Resected Pancreatic Ductal Adenocarcinoma. Annals of Surgical Oncology,15(11),pp.3138-314

• Sultana A, Neoptolemos JP, Frauscher F and Ghaneh P (2008) Gemcitabine-Based Combination Chemotherapy in the Treatment of Advanced Pancreatic Cancer. American Journal of Hematology and Oncology,7(),pp.96-100 

• Middleton G, Ghaneh P, Costello E, Greenhalf W and Neoptolemos JP (2008) New treatment options for advanced pancreatic cancer. Exp Rev Gastroenterology and Hepatology ,2(),pp.673-696 

• Ghaneh P, Costello E and Neoptolemos JP (2008) Biology and management of pancreatic cancer. Postgraduate Medical Journal,84(),pp.478-97 

• Ghaneh P, Smith R, Tudor-Smith C, Raraty M and Neoptolemos, J.P (2008) Neoadjuvant and adjuvant strategies for pancreatic cancer. European Journal of Surgery and Oncology,34(),pp.297-305 

• Al-Sarireh B, Ghaneh P, Gardner-Thorpe J, Raraty M, Hartley M, Sutton R and Neoptolemos JP (2008) Pancreas-preserving total duodenectomy in the management of duodenal polyps: complications and follow up. British Journal of Surgery,95(),pp.1506-1511 

• Smith RA, Dajani K, Dodd S, Whelan P, Raraty M, Sutton R, Campbell F, Neoptolemos JP and Ghaneh P (2008) Pre-operative resolution of jaundice following biliary stenting predicts more favourable early survival in resected pancreatic ductal adenocarcinoma. Annals of Surgical Oncology,15(),pp.3138-46 

• Smith RA, Bosonnet L, Raraty M, Sutton R, Neoptolemos JP, Campbell F and Ghaneh P (2008) Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma. American Journal of Surgery,(),pp. 

• Alexakis N, Connor S, Ghaneh P, Sutton R, Evans JC, Neoptolemos JP (2007) Complications of pancreatic surgery. In:Hakim NS, Papalois VE eds. Surgical complications: diagnosis and treatment Imperial College Press pp.xxx-xxx 

• Ghaneh P, Greenhalf W, Neoptolemos JP (2007) Factors involved in carcinogenesis and prevention in hepatobiliarycancer. In:(Jankowski), (Sampliner), (Kerr) and (Fong) eds. Structure of GI Oncology: A Critical MDT Approach Blackwell Publishing pp.??-?? 

• Ghaneh P and Neoptolemos JP (2007) Adjuvant chemotherapy for pancreatic cancer. In:(Beger HG), (Buchler M), (Kozarek R), (Lerch M), Neoptolemos J, (Warshaw A), (Whitcomb D) and (Shiratori K) eds. The Pancreas Blackwell pp.??-?? 

• Alexakis N, Ghaneh P and Neoptolemos JP (2007) Epidemiology of pancreatic cancer. In:(Beger HG), (Buchler M), (Kozarek R), (Lerch M), Neoptolemos J, (Warshaw A), (Whitcomb D) and (Shiratori K) eds. The Pancreas Blackwell pp.??-?? 

• Raraty MGT, Connor S, Evans J, Ghaneh P, Sutton R, Neoptolemos JP. (2006) Trattamento miniinvasivo della pancreatite acuta necrotizzante. In:Pedrazzoli S eds. Nuovo Trattato di Tecnica Chirurgica Pancreas - Peritoneo - Retroperitoneo - Surrene - Milza UTET pp.183-187 

• Raraty MGT, Ghaneh P and Neoptolemos JP (2005) Adjuvant and neoadjuvant treatment of resectable pancreatic cancer: what is worth attempting?. In:Dominguez-Munoz JE eds. Clinical Pancreatology for practising gastroenterologists and surgeons Blackwell pp.444-454 

• Ghaneh P, Neoptolemos JP (2005) Pancreatic Exocrine Tumors. In:Weinstein, Hawkey, Bosch eds. Clinical Gastroenterology and Hepatology. Elsevier Limited pp.521-534 

• Hugh TJ, Ghaneh P, Poston GJ (2005) Hepatic Metastases. In:Garden OJ eds. A Companion Series in Surgical Practice: Hepatobiliary and Pancreatic Surgery. Elsevier Saunders Ltd pp.97-130 

• Ghaneh P and Neoptolemos JP (2005) Pancreatic exocrine tumours. In:WM Weinstein, CJ Hawkey and J Bosch eds. Clinical Gastroenterology and Hepatology Elsevier Mosby pp.521-533 

• Ghaneh P, Neoptolemos JP (2005) Adjuvant therapy of pancreatic cancer. In:Gress et al eds. Exocrine Pancreatic Cancer. The European Pancreatic Cancer- Research Cooperative (EPC-RC) Felsenstein CCCP pp.364-381 

• Raraty MGT, Magee CJ, Ghaneh P, Neoptolemos JP. (2002) Adjuvant Chemotherapy for Pancreatic Cancer. In:J Permert, M Herrington, T Adrian eds. Controversies in Pancreatology Carlsson Communication pp.226-242