Basic Research

Our basic science programme is focussed on the systematic understanding of gene families required for cell growth control and cell division which can be broken down into four main areas:

1. Cell migration and signalling. Encompassing the role of the Ras-superfamily of GTPases and their regulators in controlling cell growth, and ubiquitin biology with particular focus on de-ubiquitinating enzymes in the attenuation of receptor signalling.

2. Maintenance of genome stability. Analysis of the 4D (temporal and spatial) control of protein kinase and phosphatase activity in cancer cell division and p53 function during DNA replication.

3. Basis of individual susceptibility to cancer.

4. Development of novel chemical compounds with anti-cancer properties and the understanding drug metabolism and adverse drug reactions.

All of this research is directly relevant to the biology involved in our internationally recognised clinical specialisations. The combination of expertise that makes up the Centre allows us to pursue an integrated molecular, chemical, and clinical approach. Because of this we are in a strong position to identify novel targets for therapeutic agents, and novel biomarkers. By providing a forum to integrate these activities, the Liverpool CR-UK Centre will promote the development of individualied therapies for cancer.

Groups Specialising in Basic Research
Cell Signalling:
Professor Michael Clague		Professor Sylvie Urbé		Dr Judy Coulson		Dr Ian Prior		Dr Daimark Bennett
Cell Growth and Division:
Dr Steve Royle
Maintenance of Genome Stability:
Dr Mark Boyd		Dr Nikolina Vlatkovic		Dr Carlos Rubbi
Microenvironment of Cancer Initiation and Progression:
Professor Chris Sanderson		Professor Andrea Varro		Professor Mark Pritchard		Dr Lugang Yu
Development of Novel Compounds:
Professor Kevin Park		Dr Neil Kitteringham