Clinical & Translational Research > Paediatric Cancer Biology > Professor Paul Losty

External Collaborations  • Action Medical Research, Horsham, West Sussex, Action Medical Research
• Oxford Radcliffe Hospitals NHS Trust, National Perinatal Epidemiology Unit Oxford University , Dr Marian Knight and Dr Jenny Kurinczuk

Internal Collaborations  • University of Liverpool, Human Anatomy and Cell Biology, Dr D Moss
• University of Liverpool, Child Health, Mr EC Jesudason
• University of Liverpool, Biological Sciences, School of, Prof MR White and Dr D Spillar
• University of Liverpool, Biological Sciences, School of, Prof DG Fernig and Prof J Turnbull

Research Awards: Principal Investigator  • Cellular Models for Studying Lung Abnormalities in Congenital Diaphragmatic Hernia.
• Exploiting mechanical stimuli to increase prenatal growth of the hypoplastic lung.
• Physiology of the pulmonary pacemaker: a new regulator of prenatal lung growth.
• Exploiting mechanical stimuli to increase prenatal growth of the hypoplastic lung.
• Sonographic measurement of peristalsis in normal human fetal airway.
• Endothelial-vascular smooth muscle interactions in the hypertensive hypoplastic perinatal lung.

Research Awards: Co-Investigator  • Birth Defects.
• Exploiting mechanical stimuli to increase prenatal growth of the hypoplastic lung.
• Physiology of the pulmonary pacemaker: a new regulator of prenatal lung growth.
• Targeted strategies to promote cell death in neuroblastoma
• Exploiting the embryonic environment to reprogram cancer stem cells in neuroblastoma
• Mechanisms of multidrug resistance proteins transcription in neuroblastoma cells

External Examination Appointments  • Kings College London (PhD) (2008)

External Roles  • Advanced Trauma Life Support Course, American College of Surgeons (Instructor) (from 1997)

McDowell H, Losty P, Barnes N, Kokai G (2009) Utility of FDG-PET/CT in the follow-up of neuroblastoma which became MIBG-negative. Pediatr Blood Cancer vol 52 issue 4 pp 552

Armstrong R, Greenhalgh KL, Rattenberry E, Judd B, Shukla R, Losty PD, Maher ER (2009) Succinate dehydrogenase subunit B (SDHB) gene deletion associated with a composite paraganglioma / neuroblastoma. J Med Genet vol 46 issue 3 pp 215-216

Sinha AK, Jesudason EC, Mallucci CL, Losty PD, Kokai G, Pizer BL (2008) Infantile myofibromatosis of the craniovertebral junction. Br J Neurosurg vol 22 issue 4 pp 575-7

Khalil BA, Baath ME, Baillie CT, Turnock RR, Taylor N, Van Saene HF, Losty PD (2008) Infection in gastroschisis : organisms and factors. Pediatr Surg Int vol 24 issue 9 pp 1031-1035

Mullassery D, Mallapa S, Shariff R, Craigie RJ, Losty PD, Kenny SE, Pilling D, Baillie CT (2008) Negative exploration for pyloric stenosis - is it preventable ?. BMC Pediatr vol 24 issue 8 pp 37

Mullassery D, Perry D, Goyal A, Jesudason EC, Losty PD (2008) Surgical practice for infantile hypertrophic pyloric stenosis in the United Kingdom and Ireland - a survey of members of the British Association of Paediatric Surgeons. J Pediatr Surg vol 43 issue 6 pp 1227-1229

Mullassery D, Llewellyn RS, Almond SL, Jesudason EC, Losty PD (2008) Oesophageal atresia with cleft lip and palate : a marker for associated lethal anomalies. Pediatr Surg Int vol 24 issue 7 pp 815-817

Khalil BA, Baillie CT, Kenny SE, Lamont GL, Turnock RR, Pizer BL, van Saene HF, Losty PD (2008) Surgical strategies in the management of ecthyma gangrenosum in paediatric oncology patients. Pediatr Surg Int vol 24 issue 7 pp 793-797

Armstrong R, Sridhar M, Greenhalgh KL, Howell L, Jones C, Landes C, McPartland JL, Moores C, Losty PD, Didi M (2008) Phaeochromocytoma in children. Arch Dis Child vol 93 issue 10 pp 899-904

Wallace HL, Connell MG, Losty PD, Jesudason EC, Southern KW (2008) Embryonic lung growth is normal in a cftr-knockout mouse model. Exp Lung Res vol 34 issue 10 pp 717-727

Mullassery D,Curran A, Losty PD (2008) Critical illness polyneuropathy following childhood appendicitis. Pediatric Surgery International vol 24 issue 9 pp 1067-8

Mullasery D, Shariff R, Craigie RJ, Losty PD, Kenny SE, Baillie CT (2007) Umbilical pyloromyotomy: comparison of vertical linea alba and transverse muscle cutting incisions.. Journal of Pediatric Surgery vol 42 issue 3 pp 525-7

Khalil BA, Corbett PA, Jones MO, Baillie CT, Southern K, Losty PD, Kenny SE (2007) Less is best? Impact of urokinase as the first line management of empyema thoracis. Pediatric Surgery International vol 23 issue 2 pp 129-33

Ba'Ath ME, Jesudason EC and Losty PD (2007) How useful is the lung head ratio in predicting outcome in the fetus with congenital diaphragmatic hernia ? - A systematic review and meta-analysis. Ultrasound in Obstetrics and Gynecology vol 30 pp 897-906

Uccini S, Mannarino O, McDowell HP, Pauser U, Vitali R, Natali PG, Altavista P, Andreano T, Coco S, Boldrini R, Bosco S, Clerico A, Cozzi D, Donfranscesco A, Inserra A, Kokai G, Losty PD, Nocotra MR, Raschella G, Tonini GP, Dominici C (2005) Clinical and molecular evidence for c-kit receptor as a therapeutic target in neuroblastic tumors. Clin Cancer Res vol 11 issue 1 pp 380-389

Khalil BA, Jesudason EC, Featherstone NC, Sarginson R, Kerr S, Ashworth M, Losty PD (2005) Oesophageal atresia and tracheoesophageal fistula. J Pediatr Surg vol 40 issue 7 pp e1-3

Featherstone NC, Jesudason EC, Connell MG, Fernig DG, Wray S, Losty PD, Burdyga TV (2005) Morphological and molecular assessment of apoptotic mechanisms in peripheral neuroblastic tumours. Am J Respir Cell Mol Biol vol 33 issue 2 pp 49-55

Goyal A, Potter F, Losty PD (2005) Recent advances in congenital diaphragmatic hernia.. J Pediatr Surg vol 40 issue 6 pp 426-8

Smith NP, Jesudason EC, Featherstone NC, Corbett HJ, Losty PD (2005) Late versus early surgical correction for congenital diaphragmatic hernia in newborn infants. Arch Dis Child vol 90 issue 4 pp CD001695

Smith NP, Jesudason EC, McDowell HP, Rowlands P, Ashworth M, Losty PD (2005) Outcome of hypospadias fistula repair. Pediatr Surg Int vol 21 issue 4 pp 103-5

Jesudason EC, Smith NP, Connell MG, Spillar DG. White MR, Fernig DG, Losty PD (2005) Abnormal lung development precedes oligohydramnios in a transgenic murine model of renal dysgenesis. Am J Respir Cell Mol Biol vol 32 issue 2 pp 783-786

Paul Losty MD FRCSI FRCS(Eng) FRCS(Ed) FRCS(Paed)
Professor of Paediatric Surgery
Tel  +44 (0)151 228 4811 Ext. 2797
Fax  0151-228-2024
Royal Liverpool Children's Hospital, Alder Hey, Eaton Road, L12 2AP
Email  Paul.Losty